Drug & supplement interaction

Ornithine Ketoglutarate (okg) + Propranolol

Propranolol brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ornithine Ketoglutarate (okg) and Propranolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ornithine Ketoglutarate (okg) and Propranolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Propranolol and Ornithine Ketoglutarate (okg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ornithine Ketoglutarate (okg) at all — not against Propranolol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ornithine Ketoglutarate (okg) safety at a glance

Ornithine Ketoglut... overall Use caution Generally well tolerated in short-term clinical studies, but long-term safety as a daily supplement is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Propranolol and Ornithine Ketoglutarate (okg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ornithine Ketoglutarate (okg) Itself Has Been Linked To

This is not an interaction — nothing below involves Propranolol. It is the side-effect record for Ornithine Ketoglutarate (okg) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ornithine Ketoglutarate (okg), this list is the first place to look.

  • Bloating or gas / Stomach pain / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, the most common adverse effects are gastrointestinal in nature, including abdominal pain, bloating, diarrhea, nausea, and vomiting.”

    Ornithine Ketoglutarate (okg) · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 67449. Karsegard, V. L., Raguso, C. A., Genton, L., Hirschel, B., and Pichard, C. L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004;20(6):515-520.
    2. 67453. Meaume, S., Kerihuel, J. C., Constans, T., Teot, L., Lerebours, E., Kern, J., and Bourdel, Marchasson, I. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J.Nutr.H PubMed
    3. 67466. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed
  • Itching Additional detail

    “Orally, pruritus has occurred rarely.”

    Ornithine Ketoglutarate (okg) · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 67466. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ornithine Ketoglutarate (okg) — expand a row for the licensed statement it rests on. We haven’t matched Propranolol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Propranolol.

Overlapping uses

What Propranolol Is Prescribed For, and What Ornithine Ketoglutarate (okg) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Propranolol is a prescription medicine with approved uses on its FDA label. Ornithine Ketoglutarate (okg) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Propranolol is prescribed for: This intravenous (IV) form of propranolol is used in hospital or clinical settings to treat dangerous heart rhythm problems. It is generally reserved for life-threatening arrhythmias (abnormal heart rhythms) or those that occur during anesthesia. Specific conditions it treats include fast heart rates coming from the upper chambers of the heart (supraventricular tachycardia), certain arrhythmias caused by digitalis toxicity, dangerous ventricular rhythms that haven't responded to other treatments, and fast heart rates caused by excess adrenaline-like substances during surgery.

Ornithine Ketoglutarate (okg) has been studied for:

  • Stroke studied, not established Ornithine Ketoglutarate (okg) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ornithine Ketoglutarate (okg) for stroke

    It is unclear if oral ornithine ketoglutarate is beneficial in patients with a recent stroke.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Propranolol on your own; if you are taking Ornithine Ketoglutarate (okg) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Propranolol

This page covers Ornithine Ketoglutarate (okg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propranolol page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 194 moderate · 37 minor.

From our pharmacist’s overview on the Propranolol page

“Propranolol (Inderal) slows the heart and lowers blood pressure, which is exactly why its 236-ingredient interaction list deserves genuine care. Five entries rate major, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Propranolol interaction page

How much people look this up

Where Ornithine Ketoglutarate (okg) and Propranolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ornithine Ketoglutarate (okg)
Steady interest

#1,379 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propranolol
Top 1%

#27 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ornithine Ketoglutarate (okg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ornithine Ketoglutarate (okg) and Propranolol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ornithine Ketoglutarate (okg)

What is Ornithine Ketoglutarate (okg)?

  • Wound healing and recovery from injury
  • Muscle preservation in older or hospitalized adults
  • Sports and athletic performance
  • Recovery from burns or surgery
  • Support during malnutrition or critical illness

Ornithine ketoglutarate (OKG) is a compound made by combining the amino acids ornithine and alpha-ketoglutarate, and it has mainly been studied in hospital settings for wound healing, burns, and malnutrition. Evidence for everyday use, such as sports performance, is limited and not convincing. Talk to your pharmacist or doctor before using it, especially if you have a health condition.

Not applicable (a synthesized amino acid salt) · Powder, capsules, tablets, and as part of clinical nutrition formulas

An interaction check asks whether these two react with each other — it does not ask whether Ornithine Ketoglutarate (okg) is a good idea for someone in your situation. Here is what our Ornithine Ketoglutarate (okg) record says about it on its own.

Ornithine Ketoglutarate (okg): dosing

There is no official standardized dose of OKG for general use. In clinical studies, doses were chosen by researchers and given to specific patient groups, often under medical care.If you use a supplement, follow the directions on the product label and do not assume more is better.

From our Ornithine Ketoglutarate (okg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ornithine Ketoglutarate (okg) monograph & all interactions
Medication

About Propranolol (Cardiovascular)

What Is Propranolol (Cardiovascular) Used For?

Brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, Half-Inderal LA, Bedranol SR, Half Beta Prograne, Beta Prograne, Lopranol LA, Slo-Pro, InnoPran XL

This intravenous (IV) form of propranolol is used in hospital or clinical settings to treat dangerous heart rhythm problems. It is generally reserved for life-threatening arrhythmias (abnormal heart rhythms) or those that occur during anesthesia.

Specific conditions it treats include fast heart rates coming from the upper chambers of the heart (supraventricular tachycardia), certain arrhythmias caused by digitalis toxicity, dangerous ventricular rhythms that haven't responded to other treatments, and fast heart rates caused by excess adrenaline-like substances during surgery.

See full Propranolol (Cardiovascular) drug information
Keep checking

Other Drugs & Ornithine Ketoglutarate (okg)

Browse every other medication we’ve checked against Ornithine Ketoglutarate (okg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ornithine Ketoglutarate (okg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ornithine Ketoglutarate (okg) list.

See the full Ornithine Ketoglutarate (okg) interactions page
See every supplement checked against Propranolol, ranked by severity
Evidence & sources

Ornithine Ketoglutarate (okg) References

The 3 references that drive our Ornithine Ketoglutarate (okg) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Karsegard, V. L., Raguso, C. A., Genton, L., Hirschel, B., and Pichard, C. L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004;20(6):515-520.
  2. Meaume, S., Kerihuel, J. C., Constans, T., Teot, L., Lerebours, E., Kern, J., and Bourdel, Marchasson, I. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J.Nutr.H PubMed
  3. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ornithine Ketoglutarate (okg) and Propranolol Together: Common Questions

Is it safe to take Ornithine Ketoglutarate (okg) with Propranolol?
We do not list a known interaction between Ornithine Ketoglutarate (okg) and Propranolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Ornithine Ketoglutarate (okg) and Propranolol used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ornithine Ketoglutarate (okg) in each. That is a conversation for your prescriber, especially if Propranolol is being adjusted to a target.
Does Propranolol interact with any supplements?
Yes. Propranolol has documented interactions with 236 supplements in our database — Ornithine Ketoglutarate (okg) is not one of them. The Propranolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ornithine Ketoglutarate (okg) monograph Uses, safety profile, and every drug interaction in one place Propranolol (Cardiovascular) drug information The full plain-English guide to this medication Propranolol supplement interactions Every supplement checked against Propranolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Propranolol and Ornithine Ketoglutarate (okg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.