Drug & supplement interaction

Orris + Glycerol Phenylbutyrate

Glycerol Phenylbutyrate brand name: Ravicti.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Orris and Glycerol Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glycerol Phenylbutyrate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Orris and Glycerol Phenylbutyrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glycerol Phenylbutyrate and Orris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Orris at all — not against Glycerol Phenylbutyrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Orris safety at a glance

Orris overall Use caution Mostly used as a fragrance; the fresh root can irritate the skin and gut and human safety data for internal use are limited.
Pregnancy Avoid Not enough safety information; avoid medicinal use during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glycerol Phenylbutyrate and Orris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Orris and Glycerol Phenylbutyrate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Stomach pain / Diarrhea reported in 12.2% of FDA reports for Glycerol Phenylbutyrate Additional detail

    Orris

    “Orally, the fresh plant juice or root can cause severe mucosal irritation, abdominal pain, vomiting, and bloody diarrhea (18).”

    Orris · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Glycerol Phenylbutyrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Glycerol Phenylbutyrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Orris

    “Topically, the fresh plant juice or root can cause severe skin and mucosal irritation (12,18). A case of allergic contact dermatitis has been reported in a 45-year-old atopic patient using a facial cream containing an extract of orris root.”

    Orris · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 106685. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

    Glycerol Phenylbutyrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Glycerol Phenylbutyrate. Read the label on DailyMed ›

Effects for Glycerol Phenylbutyrate come from the ADVERSE REACTIONS section of its FDA label; effects for Orris come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,358 voluntary FDA FAERS reports for Glycerol Phenylbutyrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Glycerol Phenylbutyrate Products Have a Food Rule — Orris Should Not Break It

At least one FDA label for a product containing Glycerol Phenylbutyrate says to take it with food. If you take Orris on an empty stomach out of habit, keep them separate — and take Glycerol Phenylbutyrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glycerol Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Instruct patients to take glycerol phenylbutyrate oral liquid with food or formula and to administer directly into the mouth via oral syringe.

From the Dosage and Administration section of the FDA label we read for Glycerol Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Glycerol Phenylbutyrate

This page covers Orris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glycerol Phenylbutyrate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Glycerol Phenylbutyrate page

“Ravicti (glycerol phenylbutyrate) pulls ammonia out of the blood in people with urea cycle disorders, so a dose that never gets absorbed is not a small problem, it can let ammonia climb toward dangerous levels. That is why this list deserves real attention even though it is short.”

Reviewed by 2 · Jul 18, 2026

Open the Glycerol Phenylbutyrate interaction page

One more smart check

Taking Orris as Part of a Dietary Supplement Product? Check It for Interactions

We hold 36 real supplement products containing Orris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orris. Even though Orris itself has no known interaction with Glycerol Phenylbutyrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Orris and Glycerol Phenylbutyrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Orris
Top half

#683 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glycerol Phenylbutyrate
Top 25%

#311 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orris reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Orris and Glycerol Phenylbutyrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Orris

What is Orris?

  • Fragrance and flavoring (perfumes, gin, cosmetics)
  • Traditional remedy for coughs and congestion
  • Skin and breath freshening
  • Teething soothers for infants (traditional, not recommended)
  • Digestive complaints (traditional use)

Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very little reliable human evidence that it treats any medical condition, and the fresh root can be irritating, so it is best thought of as a fragrance ingredient rather than a remedy. Talk to your pharmacist or doctor before using it for any health purpose.

Iris germanica · Iridaceae · Dried rhizome (orris root) and its essential oil/extract (orris butter) · Dried root pieces, powder, essential oil (orris butter), tinctures, and as a flavoring or fragrance ingredient

An interaction check asks whether these two react with each other — it does not ask whether Orris is a good idea for someone in your situation. Here is what our Orris record says about it on its own.

Orris: dosing

There is no established or standardized medicinal dose for orris root. Its main everyday uses—as a perfume ingredient or a flavoring—involve very small amounts and are not the same as taking it as a supplement.If you are considering a product that contains orris, follow the directions on the label and do not exceed them.

From our Orris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Orris monograph & all interactions
Medication

About Glycerol Phenylbutyrate

What Is Glycerol Phenylbutyrate Used For?

Brand name: Ravicti

Glycerol phenylbutyrate oral liquid — available as the brand Ravicti and as a generic — is used for the long-term (chronic) management of urea cycle disorders (UCDs). UCDs are rare inherited conditions where the body cannot properly convert ammonia into urea, causing toxic ammonia levels to build up in the blood and brain.

It is used in patients whose ammonia cannot be controlled by a low-protein diet and/or amino acid supplements alone. It must always be used alongside dietary protein restriction and, in some cases, additional dietary supplements such as essential amino acids, arginine, or citrulline. It is not for treating a sudden, severe spike in ammonia (acute hyperammonemia), and its safety and effectiveness for N-acetylglutamate synthase (NAGS) deficiency have not been established.

Most-Reported Side Effects for Glycerol Phenylbutyrate

From FAERS, the FDA’s public side-effect reporting system (1,358 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Ammonia increased 197 reports
Vomiting 165 reports
Hyperammonaemia 158 reports
Decreased appetite 104 reports
Nausea 74 reports
See full Glycerol Phenylbutyrate drug information
Keep checking

Other Drugs & Orris

Browse every other medication we’ve checked against Orris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Orris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orris list.

See the full Orris interactions page
See every supplement checked against Glycerol Phenylbutyrate, ranked by severity
Evidence & sources

Orris References

The 3 references that drive our Orris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Orris and Glycerol Phenylbutyrate Together: Common Questions

Is it safe to take Orris with Glycerol Phenylbutyrate?
We do not list a known interaction between Orris and Glycerol Phenylbutyrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Orris and Glycerol Phenylbutyrate have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Orris and Glycerol Phenylbutyrate at the same time of day?
At least one FDA label for a product containing Glycerol Phenylbutyrate says to take it with food. If you take Orris on an empty stomach out of habit, keep them separate and take Glycerol Phenylbutyrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glycerol Phenylbutyrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Glycerol Phenylbutyrate interact with any supplements?
Yes. Glycerol Phenylbutyrate has documented interactions with 17 supplements in our database — Orris is not one of them. The Glycerol Phenylbutyrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Orris monograph Uses, safety profile, and every drug interaction in one place Glycerol Phenylbutyrate drug information The full plain-English guide to this medication Glycerol Phenylbutyrate supplement interactions Every supplement checked against Glycerol Phenylbutyrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glycerol Phenylbutyrate and Orris?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.