Orris + Homatropine Methylbromide, Hydrocodone
Homatropine Methylbromide, Hydrocodone brand names: Hycodan, Tussigon.
We found no known interaction between Orris and Homatropine Methylbromide, Hydrocodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Orris and Homatropine Methylbromide, Hydrocodone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Homatropine Methylbromide, Hydrocodone and Orris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Orris at all — not against Homatropine Methylbromide, Hydrocodone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Orris safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Homatropine Methylbromide, Hydrocodone
This page covers Orris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Homatropine Methylbromide, Hydrocodone page lists 233 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).
By severity: 11 major · 181 moderate · 41 minor.
From our pharmacist’s overview on the Homatropine Methylbromide, Hydrocodone page
“Hycodan (homatropine with hydrocodone) is an opioid cough medicine, so the real danger on this list is anything that deepens sedation or slows breathing, and 78 of the 233 supplements and herbs on file do exactly that. Alcohol, whether beer or wine, sits among the 11 major-rated entries with solid human evidence behind it.”
Reviewed by 2 · Jul 18, 2026
Open the Homatropine Methylbromide, Hydrocodone interaction page
Taking Orris as Part of a Dietary Supplement Product? Check It for Interactions
We hold 36 real supplement products containing Orris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orris. Even though Orris itself has no known interaction with Homatropine Methylbromide, Hydrocodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Orris and Homatropine Methylbromide, Hydrocodone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,153 of 1,452 supplements looked up here in the last 7 days
#394 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orris reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Orris and Homatropine Methylbromide, Hydrocodone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Orris
What is Orris?
- Fragrance and flavoring (perfumes, gin, cosmetics)
- Traditional remedy for coughs and congestion
- Skin and breath freshening
- Teething soothers for infants (traditional, not recommended)
- Digestive complaints (traditional use)
Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very little reliable human evidence that it treats any medical condition, and the fresh root can be irritating, so it is best thought of as a fragrance ingredient rather than a remedy. Talk to your pharmacist or doctor before using it for any health purpose.
Iris germanica · Iridaceae · Dried rhizome (orris root) and its essential oil/extract (orris butter) · Dried root pieces, powder, essential oil (orris butter), tinctures, and as a flavoring or fragrance ingredient
An interaction check asks whether these two react with each other — it does not ask whether Orris is a good idea for someone in your situation. Here is what our Orris record says about it on its own.
Orris: dosing
There is no established or standardized medicinal dose for orris root. Its main everyday uses—as a perfume ingredient or a flavoring—involve very small amounts and are not the same as taking it as a supplement.If you are considering a product that contains orris, follow the directions on the label and do not exceed them.
From our Orris monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Orris
Browse every other medication we’ve checked against Orris — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Orris against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orris list.
Orris References
The 3 references that drive our Orris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Orris and Homatropine Methylbromide, Hydrocodone Together: Common Questions
Is it safe to take Orris with Homatropine Methylbromide, Hydrocodone?
Do Orris and Homatropine Methylbromide, Hydrocodone have any of the same side effects?
Does Homatropine Methylbromide, Hydrocodone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.