Drug & supplement interaction

Paleo Diet + Dextromethorphan HBr, Guaifenesin

Dextromethorphan HBr, Guaifenesin brand names: Vicks Formula 44E Cough & Chest Congestion Relief, Pediatric Vicks Formula 44e Cough & Chest Congesti.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Paleo Diet and Dextromethorphan HBr, Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Paleo Diet and Dextromethorphan HBr, Guaifenesin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan HBr, Guaifenesin and Paleo Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Paleo Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Paleo Diet at all — not against Dextromethorphan HBr, Guaifenesin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Paleo Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Paleo Diet safety at a glance

Paleo Diet overall Use caution Generally safe for healthy adults short-term, but it can be restrictive and may miss some nutrients.

Pregnancy Use caution May lack calcium, vitamin D, and other nutrients important in pregnancy, so get medical guidance first.

Breastfeeding Use caution Nutrient needs are high while nursing, so check with your doctor or dietitian before following a restrictive plan.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan HBr, Guaifenesin and Paleo Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Paleo Diet Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan HBr, Guaifenesin. It is the side-effect record for Paleo Diet on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Paleo Diet, this list is the first place to look.

Weight loss Additional detail
“In one case report, a breastfeeding woman reported to the emergency room with ketoacidosis after starting to follow the paleo diet. The ketoacidosis was attributed to the weight loss and carbohydrate deficit created by the diet in conjunction with the increased energy demands during lactation.”

Paleo Diet · Natural Medicines adverse-effect record, reported in lactation.
1 source cited

98133. Diamond, Evan, MD; Tibaldi, Joseph, MD. A case of ketoacidosis in a breastfeeding patient on the paleo diet. Endocrine Practice, suppl. Supplement 2; Jacksonville Vol. 22: 177.

Everything above comes from the Natural Medicines adverse-effect record for Paleo Diet — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan HBr, Guaifenesin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan HBr, Guaifenesin.

Everything else you take

See Every Supplement That Interacts With Dextromethorphan HBr, Guaifenesin

This page covers Paleo Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan HBr, Guaifenesin page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 125 moderate · 42 minor.

From our pharmacist’s overview on the Dextromethorphan HBr, Guaifenesin page

“A bad cough tends to hit when supplements are already on the counter, and anyone reaching for Vicks Formula 44E (dextromethorphan HBr and guaifenesin) should treat this list with real care, since 4 of its 171 entries carry a major rating. Two themes dominate.”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan HBr, Guaifenesin interaction page

How much people look this up

Where Paleo Diet and Dextromethorphan HBr, Guaifenesin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Paleo Diet

Steady interest

#1,259 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Dextromethorphan HBr, Guaifenesin

Top half

#947 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Paleo Diet reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Paleo Diet and Dextromethorphan HBr, Guaifenesin records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Eating pattern

About Paleo Diet

What is Paleo Diet?

Weight loss
Better blood sugar control
Heart health
Reducing processed-food intake
General wellness and energy

The Paleo diet is an eating pattern based on whole, minimally processed foods thought to resemble what early humans ate, while avoiding grains, legumes, dairy, and added sugar. Short-term studies suggest it may help with weight loss and some heart and blood-sugar markers, but long-term safety and benefits are not well proven. Talk with your doctor or a dietitian before making big diet changes, especially if you have a health condition.

Whole-food eating pattern (meats, fish, eggs, vegetables, fruits, nuts, and seeds)

An interaction check asks whether these two react with each other — it does not ask whether Paleo Diet is a good idea for someone in your situation. Here is what our Paleo Diet record says about it on its own.

Paleo Diet: dosing

Because the Paleo diet is an eating pattern and not a supplement, there is no standard "dose." Instead, it is defined by which foods are included or avoided.If you want to try it, focus on whole foods like vegetables, fruits, lean meats, fish, eggs, nuts, and seeds, and limit processed foods and added sugar. Many people do not need to follow every strict rule to gain benefit from eating fewer processed foods.It is a good idea to work with a doctor or registered dietitian, who can help you plan balanced meals and decide whether a supplement (such as calcium or vitamin D) might be needed.

From our Paleo Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Paleo Diet monograph & all interactions

Medication

About Dextromethorphan HBr, Guaifenesin

Most-Reported Side Effects for Dextromethorphan HBr, Guaifenesin

From FAERS, the FDA’s public side-effect reporting system (1,675 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 140 reports

Pneumonia 123 reports

Nausea 120 reports

Cough 119 reports

Fatigue 118 reports

Keep checking

Other Drugs & Paleo Diet

Browse every other medication we’ve checked against Paleo Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Paleo Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Paleo Diet list.

See the full Paleo Diet interactions page

See every supplement checked against Dextromethorphan HBr, Guaifenesin, ranked by severity

Evidence & sources

Paleo Diet References

The 14 references that drive our Paleo Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Jonsson, T., Granfeldt, Y., Ahren, B., Branell, U. C., Palsson, G., Hansson, A., Soderstrom, M., and Lindeberg, S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc
Lindeberg, S., Jonsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjostrom, K., and Ahren, B. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007;50(9):179 PubMed
Baumgartner, S., Imfeld, T., Schicht, O., Rath, C., Persson, R. E., and Persson, G. R. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol 2009;80(5):759-768. PubMed
Osterdahl, M., Kocturk, T., Koochek, A., and Wandell, P. E. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 2008;62(5):682-685. PubMed
Ryberg, M., Sandberg, S., Mellberg, C., Stegle, O., Lindahl, B., Larsson, C., Hauksson, J., and Olsson, T. A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. J Intern Med 2013;274(1):67- PubMed
Diamond, Evan, MD; Tibaldi, Joseph, MD. A case of ketoacidosis in a breastfeeding patient on the paleo diet. Endocrine Practice, suppl. Supplement 2; Jacksonville Vol. 22: 177.
Fenton TR, Fenton CJ. Paleo diet still lacks evidence. Am J Clin Nutr. 2016;104(3):844. PubMed
Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H. Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. Am J Clin Nutr. 2015;102(4):922-32. PubMed
Pastore RL, Brooks JT, Carbone JW. Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutr Res. 2015;35(6):474-9. PubMed
Mellberg C, Sandberg S, Ryberg M, et al. Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. 2014;68(3):350-7. PubMed
Jamka M, Kulczynski B, Juruc A, Gramza-Michalowska A, Stokes CS, Walkowiak J. The effect of the paleolithic diet vs. healthy diets on glucose and insulin homeostasis: a systematic review and meta-analysis of randomized controlled trials. J Clin Med 2020;9 PubMed
Lee JE, Titcomb TJ, Bisht B, Rubenstein LM, Louison R, Wahls TL. A modified MCT-based ketogenic diet increases plasma ß-hydroxybutyrate but has less effect on fatigue and quality of life in people with multiple sclerosis compared to a modified paleolithic
Ghaedi E, Mohammadi M, Mohammadi H, et al. Effects of a paleolithic diet on cardiovascular disease risk factors: a systematic review and meta-analysis of randomized controlled trials [published correction appears in Adv Nutr 2020 Jul 1;11(4):1054]. Adv Nu PubMed
Sohouli MH, Fatahi S, Lari A, et al. The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 2021;1-12. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Paleo Diet While Taking Dextromethorphan HBr, Guaifenesin: Common Questions

Is it safe to follow Paleo Diet while taking Dextromethorphan HBr, Guaifenesin?

We do not list a known interaction between Paleo Diet and Dextromethorphan HBr, Guaifenesin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Dextromethorphan HBr, Guaifenesin interact with any supplements?

Yes. Dextromethorphan HBr, Guaifenesin has documented interactions with 171 supplements in our database — Paleo Diet is not one of them. The Dextromethorphan HBr, Guaifenesin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Paleo Diet monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan HBr, Guaifenesin supplement interactions Every supplement checked against Dextromethorphan HBr, Guaifenesin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.