Drug & supplement interaction

Paleo Diet + Sertraline

Sertraline brand name: Zoloft.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Paleo Diet and Sertraline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Paleo Diet and Sertraline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sertraline and Paleo Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Paleo Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Paleo Diet at all — not against Sertraline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Paleo Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Paleo Diet safety at a glance

Paleo Diet overall Use caution Generally safe for healthy adults short-term, but it can be restrictive and may miss some nutrients.
Pregnancy Use caution May lack calcium, vitamin D, and other nutrients important in pregnancy, so get medical guidance first.
Breastfeeding Use caution Nutrient needs are high while nursing, so check with your doctor or dietitian before following a restrictive plan.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sertraline and Paleo Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Paleo Diet and Sertraline May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so following Paleo Diet while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Weight loss Additional detail

    Paleo Diet

    “In one case report, a breastfeeding woman reported to the emergency room with ketoacidosis after starting to follow the paleo diet. The ketoacidosis was attributed to the weight loss and carbohydrate deficit created by the diet in conjunction with the increased energy demands during lactation.”

    Paleo Diet · Natural Medicines adverse-effect record, reported in lactation.

    1 source cited
    1. 98133. Diamond, Evan, MD; Tibaldi, Joseph, MD. A case of ketoacidosis in a breastfeeding patient on the paleo diet. Endocrine Practice, suppl. Supplement 2; Jacksonville Vol. 22: 177.

    Sertraline

    Listed in the ADVERSE REACTIONS section of the FDA label for Sertraline. Read the label on DailyMed ›

Effects for Sertraline come from the ADVERSE REACTIONS section of its FDA label; effects for Paleo Diet come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 214,799 voluntary FDA FAERS reports for Sertraline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Paleo Diet or Sertraline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Paleo Diet or Sertraline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sertraline

This page covers Paleo Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sertraline page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 139 moderate · 40 minor.

From our pharmacist’s overview on the Sertraline page

“If you take sertraline (Zoloft) for depression, anxiety, or panic, treat this page with real care. Nine of the 188 supplements here carry a major rating, and the biggest issue is how your body clears the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Sertraline interaction page

How much people look this up

Where Paleo Diet and Sertraline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Paleo Diet
Steady interest

#984 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sertraline
Top 10

#5 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Paleo Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Paleo Diet and Sertraline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Paleo Diet

What is Paleo Diet?

  • Weight loss
  • Better blood sugar control
  • Heart health
  • Reducing processed-food intake
  • General wellness and energy

The Paleo diet is an eating pattern based on whole, minimally processed foods thought to resemble what early humans ate, while avoiding grains, legumes, dairy, and added sugar. Short-term studies suggest it may help with weight loss and some heart and blood-sugar markers, but long-term safety and benefits are not well proven. Talk with your doctor or a dietitian before making big diet changes, especially if you have a health condition.

Whole-food eating pattern (meats, fish, eggs, vegetables, fruits, nuts, and seeds)

An interaction check asks whether these two react with each other — it does not ask whether Paleo Diet is a good idea for someone in your situation. Here is what our Paleo Diet record says about it on its own.

Paleo Diet: dosing

Because the Paleo diet is an eating pattern and not a supplement, there is no standard "dose." Instead, it is defined by which foods are included or avoided.If you want to try it, focus on whole foods like vegetables, fruits, lean meats, fish, eggs, nuts, and seeds, and limit processed foods and added sugar. Many people do not need to follow every strict rule to gain benefit from eating fewer processed foods.It is a good idea to work with a doctor or registered dietitian, who can help you plan balanced meals and decide whether a supplement (such as calcium or vitamin D) might be needed.

From our Paleo Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Paleo Diet monograph & all interactions
Medication

About Sertraline

What Is Sertraline Used For?

Brand name: Zoloft

Sertraline treats a range of mental health conditions. All formulations are approved for major depressive disorder (MDD) in adults and obsessive-compulsive disorder (OCD). The oral solution (including Zoloft oral solution) and several tablet formulations are also approved for panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

For OCD specifically, the capsule formulations and some tablet products are approved for use in adults and children aged 6 and older. Sertraline hydrochloride tablets (plain, not film-coated) are approved for OCD in pediatric patients as well. However, sertraline is not approved for major depressive disorder in children — only in adults.

Most-Reported Side Effects for Sertraline

From FAERS, the FDA’s public side-effect reporting system (218,320 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 13,865 reports
Fatigue 12,822 reports
Headache 11,106 reports
Anxiety 10,369 reports
Diarrhea 10,339 reports
See full Sertraline drug information
Keep checking

Other Drugs & Paleo Diet

Browse every other medication we’ve checked against Paleo Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Paleo Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Paleo Diet list.

See the full Paleo Diet interactions page
See every supplement checked against Sertraline, ranked by severity
Evidence & sources

Paleo Diet References

The 14 references that drive our Paleo Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jonsson, T., Granfeldt, Y., Ahren, B., Branell, U. C., Palsson, G., Hansson, A., Soderstrom, M., and Lindeberg, S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc
  2. Lindeberg, S., Jonsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjostrom, K., and Ahren, B. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007;50(9):179 PubMed
  3. Baumgartner, S., Imfeld, T., Schicht, O., Rath, C., Persson, R. E., and Persson, G. R. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol 2009;80(5):759-768. PubMed
  4. Osterdahl, M., Kocturk, T., Koochek, A., and Wandell, P. E. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 2008;62(5):682-685. PubMed
  5. Ryberg, M., Sandberg, S., Mellberg, C., Stegle, O., Lindahl, B., Larsson, C., Hauksson, J., and Olsson, T. A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. J Intern Med 2013;274(1):67- PubMed
  6. Diamond, Evan, MD; Tibaldi, Joseph, MD. A case of ketoacidosis in a breastfeeding patient on the paleo diet. Endocrine Practice, suppl. Supplement 2; Jacksonville Vol. 22: 177.
  7. Fenton TR, Fenton CJ. Paleo diet still lacks evidence. Am J Clin Nutr. 2016;104(3):844. PubMed
  8. Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H. Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. Am J Clin Nutr. 2015;102(4):922-32. PubMed
  9. Pastore RL, Brooks JT, Carbone JW. Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutr Res. 2015;35(6):474-9. PubMed
  10. Mellberg C, Sandberg S, Ryberg M, et al. Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. 2014;68(3):350-7. PubMed
  11. Jamka M, Kulczynski B, Juruc A, Gramza-Michalowska A, Stokes CS, Walkowiak J. The effect of the paleolithic diet vs. healthy diets on glucose and insulin homeostasis: a systematic review and meta-analysis of randomized controlled trials. J Clin Med 2020;9 PubMed
  12. Lee JE, Titcomb TJ, Bisht B, Rubenstein LM, Louison R, Wahls TL. A modified MCT-based ketogenic diet increases plasma ß-hydroxybutyrate but has less effect on fatigue and quality of life in people with multiple sclerosis compared to a modified paleolithic
  13. Ghaedi E, Mohammadi M, Mohammadi H, et al. Effects of a paleolithic diet on cardiovascular disease risk factors: a systematic review and meta-analysis of randomized controlled trials [published correction appears in Adv Nutr 2020 Jul 1;11(4):1054]. Adv Nu PubMed
  14. Sohouli MH, Fatahi S, Lari A, et al. The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 2021;1-12. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Paleo Diet While Taking Sertraline: Common Questions

Is it safe to follow Paleo Diet while taking Sertraline?
We do not list a known interaction between Paleo Diet and Sertraline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Paleo Diet and Sertraline have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Sertraline interact with any supplements?
Yes. Sertraline has documented interactions with 188 supplements in our database — Paleo Diet is not one of them. The Sertraline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Paleo Diet monograph Uses, safety profile, and every drug interaction in one place Sertraline drug information The full plain-English guide to this medication Sertraline supplement interactions Every supplement checked against Sertraline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sertraline and Paleo Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.