Pellitory + Castor Oil (OTC drug)
Castor Oil (OTC drug) brand name: Purge.
We found no known interaction between Pellitory and Castor Oil (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Castor Oil (OTC drug) states a food rule worth keeping to.
Pellitory and Castor Oil (OTC drug)
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Castor Oil (OTC drug) and Pellitory in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pellitory at all — not against Castor Oil (OTC drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pellitory safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Castor Oil (OTC drug) Products Have a Food Rule — Pellitory Should Not Break It
At least one FDA label for a product containing Castor Oil (OTC drug) says to take it on an empty stomach. Most supplements — Pellitory included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Castor Oil (OTC drug) on its own and move Pellitory to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Castor Oil (OTC drug) products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Directions Preferably taken on an empty stomach.
From the Dosage and Administration section of the FDA label we read for Castor Oil (OTC drug) — where that label names a specific product, the instruction is that product's.
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Castor Oil (OTC drug)
This page covers Pellitory only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Castor Oil (OTC drug) page lists 46 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Jalap (major), Oleander (major), Alder Buckthorn (moderate) and Aloe (moderate).
By severity: 3 major · 34 moderate · 9 minor.
From our pharmacist’s overview on the Castor Oil (OTC drug) page
“Castor oil, the classic over-the-counter purgative, deserves real care around supplements. Most of what's flagged against it are herbal laxatives in their own right, and doubling up can drain enough fluid and potassium to cause genuine harm, in some cases making plants that contain heart-active compounds, oleander chief among them, far…”
Reviewed by 2 · Jul 18, 2026
Taking Pellitory as Part of a Dietary Supplement Product? Check It for Interactions
We hold 36 real supplement products containing Pellitory, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pellitory. Even though Pellitory itself has no known interaction with Castor Oil (OTC drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pellitory and Castor Oil (OTC drug) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#637 of 1,452 supplements looked up here in the last 7 days
#2,596 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pellitory reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pellitory and Castor Oil (OTC drug) records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pellitory
What is Pellitory?
- Toothache and oral discomfort
- Increasing saliva flow
- Sluggish digestion
- Traditional tonic in some folk medicine systems
Pellitory (often Anacyclus pyrethrum, the root traditionally called 'pellitory of Spain') is an herb chiefly known in folk and traditional medicine for numbing toothache and stimulating saliva. Human evidence for its benefits is very limited, so it should be viewed as a traditional remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Anacyclus pyrethrum · Asteraceae · Root · Powder, root extract, tinctures, tooth powders and mouthwashes
An interaction check asks whether these two react with each other — it does not ask whether Pellitory is a good idea for someone in your situation. Here is what our Pellitory record says about it on its own.
Pellitory: dosing
There is no well-established, standardized dose for pellitory, and product strengths vary widely.
From our Pellitory monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Pellitory
Browse every other medication we’ve checked against Pellitory — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pellitory against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Clopidogrel ›
- Escitalopram ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Amitriptyline ›
- Propranolol ›
- Methotrexate ›
- Lisdexamfetamine ›
- Isotretinoin ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Bendamustine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pellitory list.
Pellitory References
The 1 references that drive our Pellitory monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pellitory and Castor Oil (OTC drug) Together: Common Questions
Is it safe to take Pellitory with Castor Oil (OTC drug)?
Should I take Pellitory and Castor Oil (OTC drug) at the same time of day?
Does Castor Oil (OTC drug) interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Castor Oil (OTC drug) and Pellitory?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.