Drug & supplement interaction

Pink Root + Avapritinib

Avapritinib brand name: Ayvakit.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pink Root and Avapritinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Avapritinib states a food rule worth keeping to.

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Interaction report

Pink Root and Avapritinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Avapritinib and Pink Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pink Root at all — not against Avapritinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pink Root safety at a glance

Pink Root overall Use caution Pink Root can be toxic in larger doses and has little modern safety data.
Pregnancy Likely Unsafe When used orally. For pink root to be effective, it must be used along with a purgative laxative. However, purgative laxative use is contraindicated during preg... Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding because safety has not been established.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Avapritinib and Pink Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Avapritinib’s Own FDA Label Lists

This is not an interaction — none of it involves Pink Root. These are the most notable effects listed in the ADVERSE REACTIONS section of Avapritinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Memory problems Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • Bleeding or bruising Worth acting on
  • Trouble concentrating
  • A change in taste

Showing the 10 most notable of 31 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Avapritinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 12,039 voluntary FDA FAERS reports for Avapritinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pink Root’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pink Root side to compare — that is a limit of the record, not a statement that Pink Root has no side effects.

Special populations

Pink Root in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. For pink root to be effective, it must be used along with a purgative laxative. However, purgative laxative use is contraindicated during pregnancy. For this reason, pink root should not be used in pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Avapritinib Products Have a Food Rule — Pink Root Should Not Break It

At least one FDA label for a product containing Avapritinib says to take it on an empty stomach. Most supplements — Pink Root included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Avapritinib on its own and move Pink Root to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Avapritinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.7 ) 2.1 Recommended Administration Administer AYVAKIT orally on an empty stomach, at least 1 hour before or 2 hours after a meal [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Avapritinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Avapritinib

This page covers Pink Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Avapritinib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

Open the Avapritinib interaction page

One more smart check

Taking Pink Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Pink Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pink Root. Even though Pink Root itself has no known interaction with Avapritinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pink Root and Avapritinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pink Root
Steady interest

#1,006 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Avapritinib
Steady interest

#1,422 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pink Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pink Root and Avapritinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pink Root

What is Pink Root?

  • Intestinal worms (anthelmintic)
  • Digestive complaints
  • Traditional folk remedy

Pink Root (Spigelia marilandica) is a North American plant that was historically used to expel intestinal worms. It contains potentially toxic compounds, has little modern safety or effectiveness data, and is rarely used today. We do not recommend self-treating with it; talk to a healthcare provider about safer, proven options.

Spigelia marilandica · Loganiaceae · Root and rhizome · Dried root, powder, tincture, tea (decoction)

An interaction check asks whether these two react with each other — it does not ask whether Pink Root is a good idea for someone in your situation. Here is what our Pink Root record says about it on its own.

Pink Root: dosing

There is no established, standardized safe dose of Pink Root for modern use. Historical doses are not considered reliable or safe by today's standards.Because of its potential toxicity, we do not recommend self-dosing.

From our Pink Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pink Root monograph & all interactions
Medication

About Avapritinib

What Is Avapritinib Used For?

Brand name: Ayvakit

Ayvakit (avapritinib) is approved to treat adults with unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) gastrointestinal stromal tumors (GIST) that have a specific genetic mutation called a PDGFRA exon 18 mutation, including the D842V variant. Patients must be tested for this mutation before starting treatment.

Ayvakit is also approved to treat advanced systemic mastocytosis (AdvSM) — a serious condition where abnormal mast cells build up in organs — including aggressive systemic mastocytosis, systemic mastocytosis with an associated blood cancer, and mast cell leukemia. Additionally, Ayvakit treats indolent systemic mastocytosis (ISM), a less severe form of the disease. It is not recommended for either form of mastocytosis if platelet counts are too low (below 50 × 10⁹/L).

Most-Reported Side Effects for Avapritinib

From FAERS, the FDA’s public side-effect reporting system (12,039 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,735 reports
Nausea 1,218 reports
Diarrhea 1,007 reports
Headache 568 reports
Dizziness 537 reports
See full Avapritinib drug information
Keep checking

Other Drugs & Pink Root

Browse every other medication we’ve checked against Pink Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pink Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pink Root list.

See the full Pink Root interactions page
See every supplement checked against Avapritinib, ranked by severity
Evidence & sources

Pink Root References

The 1 references that drive our Pink Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pink Root and Avapritinib Together: Common Questions

Is it safe to take Pink Root with Avapritinib?
We do not list a known interaction between Pink Root and Avapritinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Pink Root and Avapritinib at the same time of day?
At least one FDA label for a product containing Avapritinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Avapritinib on its own and move Pink Root to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Avapritinib interact with any supplements?
Yes. Avapritinib has documented interactions with 138 supplements in our database — Pink Root is not one of them. The Avapritinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pink Root monograph Uses, safety profile, and every drug interaction in one place Avapritinib drug information The full plain-English guide to this medication Avapritinib supplement interactions Every supplement checked against Avapritinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Avapritinib and Pink Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.