Drug & supplement interaction

Plum + Homatropine Methylbromide, Hydrocodone

Homatropine Methylbromide, Hydrocodone brand names: Hycodan, Tussigon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Plum and Homatropine Methylbromide, Hydrocodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Plum and Homatropine Methylbromide, Hydrocodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Homatropine Methylbromide, Hydrocodone and Plum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Plum safety at a glance

Plum overall Generally safe Plums and prunes are widely eaten as food and are generally safe in normal amounts.
Pregnancy Use caution Plum as a food is generally fine, but concentrated supplements are not well studied in pregnancy.
Breastfeeding Use caution Eating plums is generally considered fine, but concentrated supplement forms lack safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Homatropine Methylbromide, Hydrocodone and Plum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Homatropine Methylbromide, Hydrocodone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Homatropine Methylbromide, Hydrocodone is filed under 7 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, anticholinergic drugs. Plum has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Homatropine Methylbromide, Hydrocodone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Plum Does Interact With Other Medications

Plum has 122 moderate known drug interactions in our database — Homatropine Methylbromide, Hydrocodone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Homatropine Methylbromide, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Plum

Covers the 2,830 medications we’ve checked against Plum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Plum and Homatropine Methylbromide, Hydrocodone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on Additional detail

    Plum

    “Orally, plum has been reported to cause gastrointestinal issues, including flatulence and diarrhea.

    In one case report, small bowel obstruction with impaction in the terminal ileum occurred in a 10-month old infant who consumed a dried plum. This was likely due to the infant being unable to properly chew the plum.

    Consumption of plum pits has also caused serious gastrointestinal adverse effects.”

    Plum · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 95272. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
    2. 95276. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
    3. 95285. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
    4. 95293. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
    5. 95300. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
    6. 95296. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed

    Homatropine Methylbromide, Hydrocodone

    Listed in the ADVERSE REACTIONS section of the FDA label for Homatropine Methylbromide, Hydrocodone. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Plum

    Recorded for Plum in the same Natural Medicines adverse-effect record shown under A bowel blockage above.

    Homatropine Methylbromide, Hydrocodone

    Listed in the ADVERSE REACTIONS section of the FDA label for Homatropine Methylbromide, Hydrocodone. Read the label on DailyMed ›

Reported for Plum but not commonly for Homatropine Methylbromide, Hydrocodone: an allergic reaction and bloating or gas.

Effects for Homatropine Methylbromide, Hydrocodone come from the ADVERSE REACTIONS section of its FDA label; effects for Plum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Homatropine Methylbromide, Hydrocodone

This page covers Plum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Homatropine Methylbromide, Hydrocodone page lists 233 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 11 major · 181 moderate · 41 minor.

From our pharmacist’s overview on the Homatropine Methylbromide, Hydrocodone page

“Hycodan (homatropine with hydrocodone) is an opioid cough medicine, so the real danger on this list is anything that deepens sedation or slows breathing, and 78 of the 233 supplements and herbs on file do exactly that. Alcohol, whether beer or wine, sits among the 11 major-rated entries with solid human evidence behind it.”

Reviewed by 2 · Jul 18, 2026

Open the Homatropine Methylbromide, Hydrocodone interaction page

One more smart check

Taking Plum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,682 real supplement products containing Plum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Plum. Even though Plum itself has no known interaction with Homatropine Methylbromide, Hydrocodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Plum and Homatropine Methylbromide, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Plum
Top 25%

#193 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Homatropine Methylbromide, Hydrocodone
Top 25%

#394 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Plum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Plum and Homatropine Methylbromide, Hydrocodone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Plum

What is Plum?

  • Constipation
  • Digestive health
  • Bone health support
  • Antioxidant source
  • General nutrition

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as food, but eating large amounts can cause gas, bloating, or loose stools. Talk to your pharmacist or doctor before using concentrated supplements, especially if you have a medical condition.

Prunus domestica · Rosaceae · Fruit (fresh and dried, also called prunes); juice · Fresh fruit, dried plums (prunes), juice, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Plum is a good idea for someone in your situation. Here is what our Plum record says about it on its own.

Plum: dosing

There is no official standardized dose for plum. As a food, people often eat a small serving of dried plums or drink a small glass of plum juice to help with constipation, then adjust based on how their body responds.For supplements, powders, or capsules, follow the directions on the product label, since strength varies between products.

From our Plum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Plum monograph & all interactions
Keep checking

Other Drugs & Plum

Browse every other medication we’ve checked against Plum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Plum page.

No interaction 2,707 drugs checked — show the list

We also checked Plum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Plum list.

See the full Plum interactions page
See every supplement checked against Homatropine Methylbromide, Hydrocodone, ranked by severity
Evidence & sources

Plum References

The 10 references that drive our Plum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
  2. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
  3. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
  4. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
  5. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed
  6. Jain M, Pielage P, De-Ryke R. Plum stones: an unusual cause of ileostomy obstruction demonstrated by sonography. J Clin Ultrasound. 1998;26(8):416-7. DOI
  7. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
  8. Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
  9. Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI
  10. Johnson MC, Fisher JK. Plum pit ileus: a case report. Mo Med. 1991;88(10):696-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Plum and Homatropine Methylbromide, Hydrocodone Together: Common Questions

Is it safe to take Plum with Homatropine Methylbromide, Hydrocodone?
We do not list a known interaction between Plum and Homatropine Methylbromide, Hydrocodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Plum and Homatropine Methylbromide, Hydrocodone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Plum and Homatropine Methylbromide, Hydrocodone combination checked?
Interactions in our licensed database are recorded against drug classes. Homatropine Methylbromide, Hydrocodone is filed under 7 classifications, and Plum has documented interactions with 1 drug class — none of Homatropine Methylbromide, Hydrocodone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Plum interact with any other medications?
Yes. Plum has 122 documented drug interactions in our database — Homatropine Methylbromide, Hydrocodone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Homatropine Methylbromide, Hydrocodone interact with any supplements?
Yes. Homatropine Methylbromide, Hydrocodone has documented interactions with 233 supplements in our database — Plum is not one of them. The Homatropine Methylbromide, Hydrocodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Plum monograph Uses, safety profile, and every drug interaction in one place Homatropine Methylbromide, Hydrocodone supplement interactions Every supplement checked against Homatropine Methylbromide, Hydrocodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Homatropine Methylbromide, Hydrocodone and Plum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.