Drug & supplement interaction

Plum + Ibuprofen, Pseudoephedrine

Ibuprofen, Pseudoephedrine brand name: Dristan.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Plum has a moderate interaction with Ibuprofen, Pseudoephedrine. Theoretically, plum juice might have antiplatelet effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Plum and Ibuprofen, Pseudoephedrine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ibuprofen, Pseudoephedrine

Ibuprofen, Pseudoephedrine falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Plum interacts with.

Theoretically, plum juice might have antiplatelet effects.
Consuming plum juice while taking anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. In healthy volunteers, drinking plum juice 200 mL daily for 28 days prolonged clotting time and inhibited platelet aggregation.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with a product like Dristan: the ibuprofen part already nudges up your bleeding risk a little on its own, since it's an NSAID that affects how your platelets stick together and can irritate the stomach lining. There's some early research suggesting plum juice (in fairly concentrated, daily amounts) may also gently thin the blood by slowing clotting and platelet clumping. Stacked together, that could mean a bit more bruising, nosebleeds, or stomach upset.

I want to be honest though, this is mostly theoretical and based on limited data. A few plums or prunes as food shouldn't be an issue. If you're drinking large amounts of plum juice regularly, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
  2. Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Plum Also Interacts With Other Medications

Plum has 121 moderate known drug interactions in our database — the Ibuprofen, Pseudoephedrine one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Ibuprofen, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Plum

Covers the 2,830 medications we’ve checked against Plum. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Pseudoephedrine

This page covers Plum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Pseudoephedrine page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Ephedra (major).

By severity: 11 major · 262 moderate · 35 minor.

Open the Ibuprofen, Pseudoephedrine interaction page

One more smart check

Taking Plum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,682 real supplement products containing Plum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Plum. Your product may carry other ingredients that interact with Ibuprofen, Pseudoephedrine too, on top of Plum — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Plum and Ibuprofen, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Plum
Top 25%

#201 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Pseudoephedrine
Top half

#868 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Plum

What is Plum?

  • Constipation
  • Digestive health
  • Bone health support
  • Antioxidant source
  • General nutrition

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as food, but eating large amounts can cause gas, bloating, or loose stools. Talk to your pharmacist or doctor before using concentrated supplements, especially if you have a medical condition.

Read the full Plum monograph & all interactions
Keep checking

Other Drugs & Plum

Browse every other medication we’ve checked against Plum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Plum page.

No interaction 2,708 drugs checked — show the list

We also checked Plum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Plum list.

See the full Plum interactions page
See every supplement checked against Ibuprofen, Pseudoephedrine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Plum monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Pseudoephedrine supplement interactions › Every supplement checked against Ibuprofen, Pseudoephedrine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Plum and Ibuprofen, Pseudoephedrine Together: Common Questions

Can you take Plum with Ibuprofen, Pseudoephedrine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Plum and Ibuprofen, Pseudoephedrine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ibuprofen, Pseudoephedrine and Plum?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.