Drug & supplement interaction

Potentilla + Darunavir, Cobicistat

Darunavir, Cobicistat brand name: Prezcobix.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Potentilla and Darunavir, Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Darunavir, Cobicistat states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Potentilla and Darunavir, Cobicistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Darunavir, Cobicistat and Potentilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Potentilla at all — not against Darunavir, Cobicistat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Potentilla safety at a glance

Potentilla overall Use caution Generally used in small traditional amounts, but human safety data are limited.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Darunavir, Cobicistat and Potentilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Darunavir, Cobicistat’s Own FDA Label Lists

This is not an interaction — none of it involves Potentilla. These are the most notable effects listed in the ADVERSE REACTIONS section of Darunavir, Cobicistat’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on
  • Liver problems Worth acting on
  • Stomach pain
  • Diarrhea
  • A skin rash
  • Vomiting
  • Headache
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Darunavir, Cobicistat. Read the label on DailyMed › Potentilla’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Potentilla side to compare — that is a limit of the record, not a statement that Potentilla has no side effects.

How to take them

Some Darunavir, Cobicistat Products Have a Food Rule — Potentilla Should Not Break It

At least one FDA label for a product containing Darunavir, Cobicistat says to take it with food. If you take Potentilla on an empty stomach out of habit, keep them separate — and take Darunavir, Cobicistat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Darunavir, Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended dosage: Adults and pediatric patients weighing at least 40 kg: One 800 mg/150 mg tablet taken once daily with food.

From the Dosage and Administration section of the FDA label we read for Darunavir, Cobicistat — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Darunavir, Cobicistat

This page covers Potentilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Darunavir, Cobicistat page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 102 moderate · 40 minor.

From our pharmacist’s overview on the Darunavir, Cobicistat page

“Prezcobix (darunavir with cobicistat) treats HIV, and it only works if it holds a steady blood level, so this list of 145 supplements deserves real care. Three carry a major rating and matter most: St.”

Reviewed by 2 · Jul 18, 2026

Open the Darunavir, Cobicistat interaction page

How much people look this up

Where Potentilla and Darunavir, Cobicistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Potentilla
Top half

#629 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Darunavir, Cobicistat
Top half

#863 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Potentilla is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Potentilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Potentilla and Darunavir, Cobicistat records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Potentilla

What is Potentilla?

  • Diarrhea and digestive upset
  • Mouth and throat sores
  • Menstrual cramps
  • Mild sore throat
  • Minor wounds and skin irritation

Potentilla is a group of tannin-rich plants long used in traditional medicine for diarrhea, mouth sores, and minor inflammation. Modern human evidence is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Argentina anserina (syn. Potentilla anserina) · Rosaceae · Roots, leaves, and aerial (above-ground) parts · Tea, tincture, capsules, mouth rinse, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Potentilla is a good idea for someone in your situation. Here is what our Potentilla record says about it on its own.

Potentilla: dosing

There is no well-established standardized dose for Potentilla. Traditional preparations include teas made from the dried root or leaves, tinctures, and mouth rinses, but the right amount varies by product and species.Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed them.

From our Potentilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Potentilla monograph & all interactions
Medication

About Darunavir and Cobicistat

What Is Darunavir and Cobicistat Used For?

Brand name: Prezcobix

Prezcobix and Prezcobix Ped are used to treat HIV-1 (human immunodeficiency virus type 1) infection. They are always used together with other antiretroviral (anti-HIV) medicines — never alone. Both products are approved for people who are new to HIV treatment (treatment-naïve) and for those who have taken HIV medicines before (treatment-experienced), as long as certain darunavir resistance mutations are not present.

Prezcobix tablets are approved for adults and pediatric patients weighing at least 40 kg. Prezcobix Ped tablets for oral suspension extend coverage to pediatric patients 3 years of age and older weighing at least 15 kg.

See full Darunavir and Cobicistat drug information
Keep checking

Other Drugs & Potentilla

Browse every other medication we’ve checked against Potentilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Potentilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Potentilla list.

See the full Potentilla interactions page
See every supplement checked against Darunavir, Cobicistat, ranked by severity
Evidence & sources

Potentilla References

The 1 sources that drive our Potentilla monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Potentilla is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Potentilla and Darunavir, Cobicistat Together: Common Questions

Is it safe to take Potentilla with Darunavir, Cobicistat?
We do not list a known interaction between Potentilla and Darunavir, Cobicistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Potentilla and Darunavir, Cobicistat at the same time of day?
At least one FDA label for a product containing Darunavir, Cobicistat says to take it with food. If you take Potentilla on an empty stomach out of habit, keep them separate and take Darunavir, Cobicistat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Darunavir, Cobicistat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Darunavir, Cobicistat interact with any supplements?
Yes. Darunavir, Cobicistat has documented interactions with 145 supplements in our database — Potentilla is not one of them. The Darunavir, Cobicistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Potentilla monograph Uses, safety profile, and every drug interaction in one place Darunavir and Cobicistat drug information The full plain-English guide to this medication Darunavir, Cobicistat supplement interactions Every supplement checked against Darunavir, Cobicistat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Darunavir, Cobicistat and Potentilla?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.