Drug & supplement interaction

Prickly Pear Cactus + Obinutuzumab

Obinutuzumab brand name: Gazyva.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Prickly Pear Cactus and Obinutuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Obinutuzumab states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Prickly Pear Cactus and Obinutuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Obinutuzumab and Prickly Pear Cactus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Prickly Pear Cactus safety at a glance

Prickly Pear Cactu... overall Use caution Generally well tolerated as food, but supplement safety is less studied.

Pregnancy Avoid Not enough safety data, so avoid supplement amounts during pregnancy.

Breastfeeding Avoid Not enough safety data, so avoid supplement amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Obinutuzumab and Prickly Pear Cactus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Prickly Pear Cactus Does Interact With Other Medications

Prickly Pear Cactus has 86 moderate known drug interactions in our database — Obinutuzumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Obinutuzumab)

Taking anything else?

Check Another of Your Medications Against Prickly Pear Cactus

Covers the 2,830 medications we’ve checked against Prickly Pear Cactus. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Prickly Pear Cactus and Obinutuzumab May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Diarrhea Additional detail
Prickly Pear Cactus
“Orally, prickly pear cactus may cause mild diarrhea, dyspepsia, nausea, increased stool volume and frequency, and abdominal fullness. Cases of low colonic obstruction and rectal phytobezoars resulting in rectal perforation have been reported for patients who ingested prickly pear cactus fruit seeds. However, these events are extremely rare and attributed to the ingestion of a large number of fruits.”

Prickly Pear Cactus · Natural Medicines adverse-effect record, reported in diarrhea.
4 sources cited

7028. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.

65266. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed

105903. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

65260. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
Obinutuzumab

Listed in the ADVERSE REACTIONS section of the FDA label for Obinutuzumab. Read the label on DailyMed ›

Reported for Prickly Pear Cactus but not commonly for Obinutuzumab: stomach upset, dizziness, hives and headache.

Effects for Obinutuzumab come from the ADVERSE REACTIONS section of its FDA label; effects for Prickly Pear Cactus come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Obinutuzumab Products Have a Food Rule — Prickly Pear Cactus Should Not Break It

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach. Most supplements — Prickly Pear Cactus included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Obinutuzumab on its own and move Prickly Pear Cactus to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Obinutuzumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

650–1,000 mg acetaminophen At least 30 minutes before GAZYVA infusion.

From the Dosage and Administration section of the FDA label we read for Obinutuzumab — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

One more smart check

Taking Prickly Pear Cactus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 432 real supplement products containing Prickly Pear Cactus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Prickly Pear Cactus. Even though Prickly Pear Cactus itself has no known interaction with Obinutuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Prickly Pear Cactus and Obinutuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Prickly Pear Cactus

Top half

#465 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Obinutuzumab

Steady interest

#1,860 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Prickly Pear Cactus reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Prickly Pear Cactus and Obinutuzumab records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Prickly Pear Cactus

What is Prickly Pear Cactus?

Blood sugar control
High cholesterol
Hangover symptoms
Digestive health
Antioxidant support

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest modest benefits, but the evidence is limited and not strong enough to rely on it as a treatment. Talk with your pharmacist or doctor before using it, especially if you take medication for diabetes.

Opuntia ficus-indica · Cactaceae · Pads (cladodes), fruit, and flowers · Capsules, powder, juice, dried fruit, fresh pads, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Prickly Pear Cactus is a good idea for someone in your situation. Here is what our Prickly Pear Cactus record says about it on its own.

Prickly Pear Cactus: dosing

There is no standardized, official dose for prickly pear cactus supplements. The right amount depends on the product, the form (capsule, powder, juice, or extract), and how it is being used.Because doses are not well established, follow the directions on the product label and do not exceed them. A pharmacist can help you review a specific product and decide whether it is appropriate for you, especially if you have diabetes or take other medicines.

From our Prickly Pear Cactus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Prickly Pear Cactus monograph & all interactions

Medication

About Obinutuzumab Injection

What Is Obinutuzumab Injection Used For?

Brand name: Gazyva

Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy.

Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

See full Obinutuzumab Injection drug information

Keep checking

Other Drugs & Prickly Pear Cactus

Browse every other medication we’ve checked against Prickly Pear Cactus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

86Moderate

0Minor

2,743No known interaction

86 Moderate 2,743 No interaction

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Prickly Pear Cactus page.

No interaction 2,743 drugs checked — show the list

We also checked Prickly Pear Cactus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Prickly Pear Cactus list.

See the full Prickly Pear Cactus interactions page

See every supplement checked against Obinutuzumab, ranked by severity

Evidence & sources

Prickly Pear Cactus References

The 9 references that drive our Prickly Pear Cactus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Prickly Pear Cactus and Obinutuzumab Together: Common Questions

Is it safe to take Prickly Pear Cactus with Obinutuzumab?

We do not list a known interaction between Prickly Pear Cactus and Obinutuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Prickly Pear Cactus and Obinutuzumab have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Prickly Pear Cactus and Obinutuzumab at the same time of day?

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Obinutuzumab on its own and move Prickly Pear Cactus to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Does Prickly Pear Cactus interact with any other medications?

Yes. Prickly Pear Cactus has 86 documented drug interactions in our database — Obinutuzumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Prickly Pear Cactus monograph Uses, safety profile, and every drug interaction in one place Obinutuzumab Injection drug information The full plain-English guide to this medication Obinutuzumab supplement interactions Every supplement checked against Obinutuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Obinutuzumab and Prickly Pear Cactus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.