Drug & supplement interaction

Prickly Pear Cactus + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Prickly Pear Cactus and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Prickly Pear Cactus and Amphetamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amphetamine and Prickly Pear Cactus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Prickly Pear Cactus safety at a glance

Prickly Pear Cactu... overall Use caution Generally well tolerated as food, but supplement safety is less studied.
Pregnancy Avoid Not enough safety data, so avoid supplement amounts during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid supplement amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amphetamine and Prickly Pear Cactus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amphetamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amphetamine is filed under 6 classifications — including monoamine oxidase inhibitors (maois), amphetamines, stimulant drugs. Prickly Pear Cactus has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Amphetamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Prickly Pear Cactus Does Interact With Other Medications

Prickly Pear Cactus has 86 moderate known drug interactions in our database — Amphetamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Amphetamine)
Taking anything else?

Check Another of Your Medications Against Prickly Pear Cactus

Covers the 2,830 medications we’ve checked against Prickly Pear Cactus. Pick one to open its full report.

What to actually watch for

What Prickly Pear Cactus Itself Has Been Linked To

This is not an interaction — nothing below involves Amphetamine. It is the side-effect record for Prickly Pear Cactus on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Prickly Pear Cactus, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Hives Worth acting on Additional detail

    “Orally, prickly pear cactus has been linked to rare cases of urticaria and pruritus. In a clinical study of 41 patients taking prickly pear cactus pad ethanolic extract, three patients experienced pruritus and one patient experienced urticaria.”

    Prickly Pear Cactus · Natural Medicines adverse-effect record, reported in peripheral arterial disease (pad).

    1 source cited
    1. 105903. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11
  • Trouble sleeping / Dizziness / Headache Additional detail

    “Orally, prickly pear cactus has been linked to rare cases of headache, insomnia, and dizziness. In a clinical study of 41 patients taking prickly pear cactus pad ethanolic extract, two patients experienced headache, one patient experienced dizziness, and one patient experienced insomnia.”

    Prickly Pear Cactus · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 65266. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
    2. 105903. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11
  • Stomach upset / Diarrhea / Nausea Additional detail

    “Orally, prickly pear cactus may cause mild diarrhea, dyspepsia, nausea, increased stool volume and frequency, and abdominal fullness. Cases of low colonic obstruction and rectal phytobezoars resulting in rectal perforation have been reported for patients who ingested prickly pear cactus fruit seeds. However, these events are extremely rare and attributed to the ingestion of a large number of fruits.”

    Prickly Pear Cactus · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 7028. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
    2. 65266. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
    3. 105903. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11
    4. 65260. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  • Itching Additional detail

    Recorded for Prickly Pear Cactus in the same Natural Medicines adverse-effect record shown under Hives above.

Everything above comes from the Natural Medicines adverse-effect record for Prickly Pear Cactus — expand a row for the licensed statement it rests on. We haven’t matched Amphetamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amphetamine.

Overlapping uses

What Amphetamine Is Prescribed For, and What Prickly Pear Cactus Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amphetamine is a prescription medicine with approved uses on its FDA label. Prickly Pear Cactus is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amphetamine is prescribed for: Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group. Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

Prickly Pear Cactus has been studied for:

  • Obesity studied, not established Prickly Pear Cactus has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Prickly Pear Cactus for obesity

    It is unclear if oral prickly pear cactus is beneficial for weight loss.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amphetamine on your own; if you are taking Prickly Pear Cactus for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Prickly Pear Cactus or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Prickly Pear Cactus or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Prickly Pear Cactus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Prickly Pear Cactus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 432 real supplement products containing Prickly Pear Cactus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Prickly Pear Cactus. Even though Prickly Pear Cactus itself has no known interaction with Amphetamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Prickly Pear Cactus and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Prickly Pear Cactus
Top half

#378 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amphetamine
Top 5%

#46 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Prickly Pear Cactus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Prickly Pear Cactus and Amphetamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Prickly Pear Cactus

What is Prickly Pear Cactus?

  • Blood sugar control
  • High cholesterol
  • Hangover symptoms
  • Digestive health
  • Antioxidant support

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest modest benefits, but the evidence is limited and not strong enough to rely on it as a treatment. Talk with your pharmacist or doctor before using it, especially if you take medication for diabetes.

Opuntia ficus-indica · Cactaceae · Pads (cladodes), fruit, and flowers · Capsules, powder, juice, dried fruit, fresh pads, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Prickly Pear Cactus is a good idea for someone in your situation. Here is what our Prickly Pear Cactus record says about it on its own.

Prickly Pear Cactus: dosing

There is no standardized, official dose for prickly pear cactus supplements. The right amount depends on the product, the form (capsule, powder, juice, or extract), and how it is being used.Because doses are not well established, follow the directions on the product label and do not exceed them. A pharmacist can help you review a specific product and decide whether it is appropriate for you, especially if you have diabetes or take other medicines.

From our Prickly Pear Cactus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Prickly Pear Cactus monograph & all interactions
Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

See full Amphetamine drug information
Keep checking

Other Drugs & Prickly Pear Cactus

Browse every other medication we’ve checked against Prickly Pear Cactus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Prickly Pear Cactus page.

No interaction 2,743 drugs checked — show the list

We also checked Prickly Pear Cactus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Prickly Pear Cactus list.

See the full Prickly Pear Cactus interactions page
See every supplement checked against Amphetamine, ranked by severity
Evidence & sources

Prickly Pear Cactus References

The 9 references that drive our Prickly Pear Cactus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Prickly Pear Cactus and Amphetamine Together: Common Questions

Is it safe to take Prickly Pear Cactus with Amphetamine?
We do not list a known interaction between Prickly Pear Cactus and Amphetamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Prickly Pear Cactus and Amphetamine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Prickly Pear Cactus in each. That is a conversation for your prescriber, especially if Amphetamine is being adjusted to a target.
How was the Prickly Pear Cactus and Amphetamine combination checked?
Interactions in our licensed database are recorded against drug classes. Amphetamine is filed under 6 classifications, and Prickly Pear Cactus has documented interactions with 1 drug class — none of Amphetamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Prickly Pear Cactus interact with any other medications?
Yes. Prickly Pear Cactus has 86 documented drug interactions in our database — Amphetamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amphetamine interact with any supplements?
Yes. Amphetamine has documented interactions with 130 supplements in our database — Prickly Pear Cactus is not one of them. The Amphetamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Prickly Pear Cactus monograph Uses, safety profile, and every drug interaction in one place Amphetamine drug information The full plain-English guide to this medication Amphetamine supplement interactions Every supplement checked against Amphetamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amphetamine and Prickly Pear Cactus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.