Pumpkin + Osimertinib Mesylate
Osimertinib Mesylate brand name: Tagrisso.
We found no known interaction between Pumpkin and Osimertinib Mesylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Pumpkin and Osimertinib Mesylate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Osimertinib Mesylate and Pumpkin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pumpkin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Osimertinib Mesylate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Osimertinib Mesylate is filed under 6 classifications — including cytochrome p450 1a2 (cyp1a2) inhibitors, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors. Pumpkin has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Osimertinib Mesylate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Pumpkin Does Interact With Other Medications
Pumpkin has 1 moderate known drug interaction in our database — Osimertinib Mesylate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Pumpkin
We haven’t checked that one against Pumpkin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Pumpkin. Pick one to open its full report.
Questions About Pumpkin or Osimertinib Mesylate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pumpkin or Osimertinib Mesylate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Red Yeast Rice Interact With Tagrisso? ›
- Are There Any Concerns Taking Tagrisso With Dietary Supplements? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Osimertinib Mesylate
This page covers Pumpkin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Osimertinib Mesylate page lists 164 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).
By severity: 8 major · 117 moderate · 39 minor.
From our pharmacist’s overview on the Osimertinib Mesylate page
“Osimertinib (Tagrisso) treats EGFR-mutated lung cancer, and this is a list to read carefully before you add anything from the supplement aisle. Of the 164 ingredients on file, most can change how much drug reaches your blood, chiefly through the CYP3A4 enzyme that clears it.”
Reviewed by 2 · Jul 18, 2026
Taking Pumpkin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,055 real supplement products containing Pumpkin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pumpkin. Even though Pumpkin itself has no known interaction with Osimertinib Mesylate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pumpkin and Osimertinib Mesylate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#146 of 1,452 supplements looked up here in the last 7 days
#1,211 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pumpkin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pumpkin and Osimertinib Mesylate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pumpkin
What is Pumpkin?
- Benign prostatic hyperplasia (BPH) symptoms
- Overactive bladder
- Eye and skin health (vitamin A source)
- General nutrition and fiber
- Hair health
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and mostly preliminary, though eating pumpkin as a food is safe and a good source of vitamin A, fiber, and antioxidants. Talk to your pharmacist or doctor before using concentrated pumpkin seed supplements.
Cucurbita pepo · Cucurbitaceae · Fruit flesh, seeds, and seed oil · Whole food, capsules, softgels (seed oil), powders, raw or roasted seeds
An interaction check asks whether these two react with each other — it does not ask whether Pumpkin is a good idea for someone in your situation. Here is what our Pumpkin record says about it on its own.
Pumpkin: dosing
There is no official standardized dose for pumpkin supplements. Studies have used different forms and amounts of seed or seed oil, so it is hard to recommend one exact dose.The best approach is to follow the directions on the product label and not exceed the recommended amount.
From our Pumpkin monograph — the full record covers uses, side effects and every documented interaction.
About Osimertinib
What Is Osimertinib Used For?
Brand name: Tagrisso
Tagrisso is used to treat adults with non-small cell lung cancer (NSCLC) whose tumors have specific EGFR mutations — either an exon 19 deletion or an exon 21 L858R mutation — confirmed by an FDA-approved test. It is used in several settings: after surgery to reduce the risk of cancer returning (adjuvant therapy), for locally advanced stage III NSCLC that has not progressed after chemoradiation, and as a first-line treatment for locally advanced or metastatic NSCLC (including in combination with pemetrexed and platinum-based chemotherapy).
Tagrisso is also approved for adults with metastatic NSCLC that carries a specific resistance mutation called T790M, when the cancer has stopped responding to another EGFR-targeted therapy.
Other Drugs & Pumpkin
Browse every other medication we’ve checked against Pumpkin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Pumpkin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Isotretinoin ›
- Fluoxetine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Amlodipine Besylate ›
- Gabapentin ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Naproxen ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Pumpkin list.
Pumpkin References
The 5 references that drive our Pumpkin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
- Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
- Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
- Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pumpkin and Osimertinib Mesylate Together: Common Questions
Is it safe to take Pumpkin with Osimertinib Mesylate?
Do Pumpkin and Osimertinib Mesylate have any of the same side effects?
How was the Pumpkin and Osimertinib Mesylate combination checked?
Does Pumpkin interact with any other medications?
Does Osimertinib Mesylate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Osimertinib Mesylate and Pumpkin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.