Sida Cordifolia - Tosymra (Sumatriptan) Interaction
Herbal: Sida Cordifolia
Also Known As: Abutilon en Épi, Bala, Bariar, Chitramutti, Country Mallow, Guimauve, Heartleaf, Indian Chikana, Indian Ephedra, Khareti, Malva Blanca, Malva-Branca, Malva-Branca-Sedosa, Mauve Blanc, Mauve du Pays, Silky White Mallow, Vatya, White Mallow
Drug: Sumatriptan
Brand names:
Tosymra
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Sumatriptan is classified as belonging to the following category: Qt Interval-Prolonging Drugs
Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.
Sida cordifolia contains ephedrine. Clinical research shows that ephedrine from another herb, ephedra, can prolong the QT interval.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004;291:216-21.
Sida Cordifolia Overview
Sida cordifolia, also known as country mallow or heart-leaved sida, is a plant species in the mallow family (Malvaceae) and native to India.
Sida cordifolia has been used traditionally in herbal medicine to treat a range of conditions, including fever, cough, asthma, and skin conditions. It is also believed to have anti-inflammatory and diuretic properties.
Sida cordifolia contains, among other compounds, ephedrine, which has been banned for use as a dietary supplement.
Sumatriptan Overview
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Sumatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea or sensitivity to sound and light). Sumatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the head, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Sumatriptan does not prevent migraine attacks or reduce the number of headaches you have.
Sida Cordifolia - More Interactions
Sida Cordifolia interacts with 438 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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