Drug & supplement interaction

Smooth Alder + nitisinone

nitisinone brand names: Orfadin, Nityr.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Smooth Alder and nitisinone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Smooth Alder and nitisinone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nitisinone and Smooth Alder in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Smooth Alder at all — not against nitisinone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Smooth Alder safety at a glance

Smooth Alder overall Not established There is very little research on its safety in humans, so caution is warranted.
Pregnancy Avoid Safety has not been studied, so it is best avoided during pregnancy.
Breastfeeding Avoid No safety data exists for nursing, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nitisinone and Smooth Alder? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What nitisinone’s Own FDA Label Lists

This is not an interaction — none of it involves Smooth Alder. These are the most notable effects listed in the ADVERSE REACTIONS section of nitisinone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • Seizures Worth acting on
  • A low platelet count Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Dry skin
  • Hair loss
  • Itching
  • Stomach pain

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for nitisinone. Read the label on DailyMed › Where a percentage is shown, it is the share of 948 voluntary FDA FAERS reports for nitisinone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Smooth Alder’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Smooth Alder side to compare — that is a limit of the record, not a statement that Smooth Alder has no side effects.

Everything else you take

See Every Supplement That Interacts With nitisinone

This page covers Smooth Alder only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nitisinone page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cannabinol (cbn) (moderate), Cannabis (moderate), Coffee Charcoal (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the nitisinone page

“For a child or adult with hereditary tyrosinemia type 1, nitisinone (Orfadin, Nityr) is the medication holding a dangerous metabolic disease in check, which is why the 21 supplements on this page warrant genuine care rather than a shrug. Activated charcoal is the single major-rated entry and the one to understand first, since it can so…”

Reviewed by 2 · Jul 18, 2026

Open the nitisinone interaction page

One more smart check

Taking Smooth Alder as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Smooth Alder, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Smooth Alder. Even though Smooth Alder itself has no known interaction with nitisinone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Smooth Alder and nitisinone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Smooth Alder
Steady interest

#847 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nitisinone
Top half

#919 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Smooth Alder is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Smooth Alder reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Smooth Alder and nitisinone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Smooth Alder

What is Smooth Alder?

  • Skin irritation and wounds
  • Sore throat and mouth rinse
  • Digestive complaints
  • Astringent for inflammation
  • Traditional fever remedy

Smooth Alder is a North American shrub used in traditional and folk medicine, mainly as an astringent for skin and mouth complaints. Modern scientific evidence supporting any health benefit is very limited, so it should be used cautiously and never as a substitute for proven treatments.

Alnus serrulata · Betulaceae · Bark, leaves, and sometimes cones · Tea, decoction, tincture, topical wash

An interaction check asks whether these two react with each other — it does not ask whether Smooth Alder is a good idea for someone in your situation. Here is what our Smooth Alder record says about it on its own.

Smooth Alder: dosing

There is no established standardized dose for Smooth Alder. It has been used traditionally as a tea or topical wash made from the bark or leaves, but reliable, tested dosing guidelines do not exist.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Smooth Alder monograph — the full record covers uses, side effects and every documented interaction.

Read the full Smooth Alder monograph & all interactions
Medication

About Nitisinone

What Is Nitisinone Used For?

Brand names: Orfadin, Nityr

Nitisinone (as Orfadin capsules, Orfadin oral suspension, Nityr tablets, and generic Nitisinone capsules) is used to treat hereditary tyrosinemia type 1 (HT-1) — a rare inherited disease in which the body cannot properly break down the amino acid tyrosine, leading to toxic buildup that damages the liver and kidneys. It is used in both adults and children, always together with a strict low-tyrosine, low-phenylalanine diet.

Harliku tablets are approved for a different rare inherited condition: alkaptonuria (AKU). In adults with AKU, Harliku reduces the level of homogentisic acid (HGA) — a harmful substance that builds up in the urine and body tissues. Harliku is not approved for HT-1, and the other nitisinone products are not approved for AKU.

Most-Reported Side Effects for nitisinone

From FAERS, the FDA’s public side-effect reporting system (948 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Amino acid level increased 133 reports
Liver transplant 118 reports
Hepatocellular carcinoma 61 reports
Alpha 1 foetoprotein increased 52 reports
Treatment noncompliance 51 reports
See full Nitisinone drug information
Keep checking

Other Drugs & Smooth Alder

Browse every other medication we’ve checked against Smooth Alder — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Smooth Alder against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Smooth Alder list.

See the full Smooth Alder interactions page
See every supplement checked against nitisinone, ranked by severity
Evidence & sources

Smooth Alder References

The 2 sources that drive our Smooth Alder monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Smooth Alder is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Smooth Alder and nitisinone Together: Common Questions

Is it safe to take Smooth Alder with nitisinone?
We do not list a known interaction between Smooth Alder and nitisinone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does nitisinone interact with any supplements?
Yes. nitisinone has documented interactions with 21 supplements in our database — Smooth Alder is not one of them. The nitisinone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Smooth Alder monograph Uses, safety profile, and every drug interaction in one place Nitisinone drug information The full plain-English guide to this medication nitisinone supplement interactions Every supplement checked against nitisinone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About nitisinone and Smooth Alder?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.