Drug & supplement interaction

Stavesacre + Nicotine

Nicotine brand names: Nicotrol, Habitrol, Nicoderm CQ, Nicorette, Nicotrol Inhaler, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Stavesacre and Nicotine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Stavesacre and Nicotine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nicotine and Stavesacre in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Stavesacre at all — not against Nicotine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stavesacre safety at a glance

Stavesacre overall Avoid The seeds contain toxic alkaloids and can be dangerous, especially if swallowed.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nicotine and Stavesacre? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Stavesacre and Nicotine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching reported in 5.8% of FDA reports for Nicotine Additional detail

    Stavesacre

    “Orally, stavesacre seed extract can cause pruritus (18).

    Topically, stavesacre seed has been reported to cause inflammation, eczema, and reddening of the skin (18).”

    Stavesacre · Natural Medicines adverse-effect record, reported in eczema.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Nicotine

    Listed in the ADVERSE REACTIONS section of the FDA label for Nicotine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 7.7% of FDA reports for Nicotine Additional detail

    Stavesacre

    “Orally, stavesacre seed extract has been reported to cause inflammation of the gastrointestinal tract (18,19), nausea, and stool urgency (18).”

    Stavesacre · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    Nicotine

    Listed in the ADVERSE REACTIONS section of the FDA label for Nicotine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Nicotine come from the ADVERSE REACTIONS section of its FDA label; effects for Stavesacre come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 60,670 voluntary FDA FAERS reports for Nicotine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Stavesacre in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Nicotine

This page covers Stavesacre only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nicotine page lists 64 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 46 moderate · 13 minor.

From our pharmacist’s overview on the Nicotine page

“Nicotine itself is a stimulant, whether it comes from a Nicoderm CQ patch, Nicorette gum, or a Nicotrol inhaler, so treat this list with genuine care. Of the 64 supplements and herbs on file, 44 add more stimulation on top of the nicotine, which can push heart rate and blood pressure higher than either would alone.”

Reviewed by 2 · Jul 18, 2026

Open the Nicotine interaction page

How much people look this up

Where Stavesacre and Nicotine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stavesacre
Top half

#686 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nicotine
Top 25%

#307 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stavesacre reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Stavesacre and Nicotine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stavesacre

What is Stavesacre?

  • Head lice and body lice
  • Skin parasites and scabies
  • Toothache (traditional)
  • Homeopathic remedy for various complaints

Stavesacre is a flowering plant whose seeds were historically used to kill lice and other parasites because they contain toxic alkaloids. It is highly poisonous if swallowed, modern safety data are very limited, and far safer lice treatments now exist, so it is not recommended for internal use.

Delphinium staphisagria · Ranunculaceae · Seeds · Topical preparations, lotions, homeopathic remedies, historically powdered seeds

An interaction check asks whether these two react with each other — it does not ask whether Stavesacre is a good idea for someone in your situation. Here is what our Stavesacre record says about it on its own.

Stavesacre: dosing

There is no established safe or standardized dose for stavesacre, and it is not recommended for internal use because of its toxicity. Because of the poisoning risk, it should not be taken by mouth in any amount.If you come across a topical or homeopathic product containing stavesacre, follow the product label carefully and use it only as directed.

From our Stavesacre monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stavesacre monograph & all interactions
Medication

About Nicotine

Most-Reported Side Effects for Nicotine

From FAERS, the FDA’s public side-effect reporting system (60,670 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nicotine dependence 6,170 reports
Nausea 4,675 reports
Intentional drug misuse 3,782 reports
Application site erythema 3,559 reports
Application site pruritus 3,506 reports
Keep checking

Other Drugs & Stavesacre

Browse every other medication we’ve checked against Stavesacre — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Stavesacre against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stavesacre list.

See the full Stavesacre interactions page
See every supplement checked against Nicotine, ranked by severity
Evidence & sources

Stavesacre References

The 2 references that drive our Stavesacre monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stavesacre and Nicotine Together: Common Questions

Is it safe to take Stavesacre with Nicotine?
We do not list a known interaction between Stavesacre and Nicotine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Stavesacre and Nicotine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Nicotine interact with any supplements?
Yes. Nicotine has documented interactions with 64 supplements in our database — Stavesacre is not one of them. The Nicotine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stavesacre monograph Uses, safety profile, and every drug interaction in one place Nicotine supplement interactions Every supplement checked against Nicotine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nicotine and Stavesacre?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.