Drug & supplement interaction

Stavesacre + Pseudoephedrine , Guaifenesin

Pseudoephedrine , Guaifenesin brand names: Tussin PE, Robitussin PE.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Stavesacre and Pseudoephedrine , Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Stavesacre and Pseudoephedrine , Guaifenesin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pseudoephedrine , Guaifenesin and Stavesacre in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Stavesacre at all — not against Pseudoephedrine , Guaifenesin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stavesacre safety at a glance

Stavesacre overall Avoid The seeds contain toxic alkaloids and can be dangerous, especially if swallowed.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pseudoephedrine , Guaifenesin and Stavesacre? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Stavesacre Itself Has Been Linked To

This is not an interaction — nothing below involves Pseudoephedrine , Guaifenesin. It is the side-effect record for Stavesacre on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Stavesacre, this list is the first place to look.

  • Itching Additional detail

    “Orally, stavesacre seed extract can cause pruritus (18).

    Topically, stavesacre seed has been reported to cause inflammation, eczema, and reddening of the skin (18).”

    Stavesacre · Natural Medicines adverse-effect record, reported in eczema.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Nausea Additional detail

    “Orally, stavesacre seed extract has been reported to cause inflammation of the gastrointestinal tract (18,19), nausea, and stool urgency (18).”

    Stavesacre · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Everything above comes from the Natural Medicines adverse-effect record for Stavesacre — expand a row for the licensed statement it rests on. We haven’t matched Pseudoephedrine , Guaifenesin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Pseudoephedrine , Guaifenesin.

Special populations

Stavesacre in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pseudoephedrine , Guaifenesin

This page covers Stavesacre only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pseudoephedrine , Guaifenesin page lists 63 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 45 moderate · 13 minor.

Open the Pseudoephedrine , Guaifenesin interaction page

How much people look this up

Where Stavesacre and Pseudoephedrine , Guaifenesin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stavesacre
Steady interest

#1,005 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pseudoephedrine , Guaifenesin
Top 10%

#188 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stavesacre reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Stavesacre and Pseudoephedrine , Guaifenesin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stavesacre

What is Stavesacre?

  • Head lice and body lice
  • Skin parasites and scabies
  • Toothache (traditional)
  • Homeopathic remedy for various complaints

Stavesacre is a flowering plant whose seeds were historically used to kill lice and other parasites because they contain toxic alkaloids. It is highly poisonous if swallowed, modern safety data are very limited, and far safer lice treatments now exist, so it is not recommended for internal use.

Delphinium staphisagria · Ranunculaceae · Seeds · Topical preparations, lotions, homeopathic remedies, historically powdered seeds

An interaction check asks whether these two react with each other — it does not ask whether Stavesacre is a good idea for someone in your situation. Here is what our Stavesacre record says about it on its own.

Stavesacre: dosing

There is no established safe or standardized dose for stavesacre, and it is not recommended for internal use because of its toxicity. Because of the poisoning risk, it should not be taken by mouth in any amount.If you come across a topical or homeopathic product containing stavesacre, follow the product label carefully and use it only as directed.

From our Stavesacre monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stavesacre monograph & all interactions
Keep checking

Other Drugs & Stavesacre

Browse every other medication we’ve checked against Stavesacre — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Stavesacre against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stavesacre list.

See the full Stavesacre interactions page
See every supplement checked against Pseudoephedrine , Guaifenesin, ranked by severity
Evidence & sources

Stavesacre References

The 2 references that drive our Stavesacre monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stavesacre and Pseudoephedrine , Guaifenesin Together: Common Questions

Is it safe to take Stavesacre with Pseudoephedrine , Guaifenesin?
We do not list a known interaction between Stavesacre and Pseudoephedrine , Guaifenesin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Pseudoephedrine , Guaifenesin interact with any supplements?
Yes. Pseudoephedrine , Guaifenesin has documented interactions with 63 supplements in our database — Stavesacre is not one of them. The Pseudoephedrine , Guaifenesin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stavesacre monograph Uses, safety profile, and every drug interaction in one place Pseudoephedrine , Guaifenesin supplement interactions Every supplement checked against Pseudoephedrine , Guaifenesin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pseudoephedrine , Guaifenesin and Stavesacre?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.