Drug & supplement interaction

Trager Therapy + Medroxyprogesterone

Medroxyprogesterone brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Trager Therapy and Medroxyprogesterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone interested in this? Share
Facebook Post Reddit Email
On this page
Interaction report

Trager Therapy and Medroxyprogesterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone and Trager Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Trager Therapy alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Trager Therapy at all — not against Medroxyprogesterone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Trager Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Trager Therapy safety at a glance

Trager Therapy overall Use caution Generally gentle and low-risk, but evidence is limited and it should not replace medical care.
Pregnancy Use caution Tell your practitioner if you are pregnant and check with your doctor first, since positioning and pressure may need to be adjusted.
Breastfeeding Use caution No specific concerns are known, but discuss with your healthcare provider before starting.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone and Trager Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Medroxyprogesterone’s Own FDA Label Lists

This is not an interaction — none of it involves Trager Therapy. These are the most notable effects listed in the ADVERSE REACTIONS section of Medroxyprogesterone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you have Trager Therapy and take the medicine. 5 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • A change in sex drive
  • Breast tenderness
  • Acne
  • Weight gain

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone. Read the label on DailyMed › Where a percentage is shown, it is the share of 60,501 voluntary FDA FAERS reports for Medroxyprogesterone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Trager Therapy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Trager Therapy side to compare — that is a limit of the record, not a statement that Trager Therapy has no side effects.

From our Q&A

Questions About Trager Therapy or Medroxyprogesterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Trager Therapy or Medroxyprogesterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone

This page covers Trager Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Medroxyprogesterone page

“Medroxyprogesterone (Provera, Depo-Provera) only works if its blood level holds steady, and 121 of the 139 supplements and herbs on file can shift that level through a single liver enzyme, CYP3A4. That makes this a list to respect, with three entries rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Medroxyprogesterone interaction page

How much people look this up

Where Trager Therapy and Medroxyprogesterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Trager Therapy
Steady interest

#1,135 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone
Steady interest

#1,509 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Trager Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Trager Therapy and Medroxyprogesterone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Trager Therapy

What is Trager Therapy?

  • Muscle tension and stiffness
  • Chronic pain and back pain
  • Stress and relaxation
  • Improving mobility and posture
  • Easing tension related to chronic conditions

Trager Therapy (also called the Trager Approach) is a gentle, hands-on bodywork and movement education method, not a dietary supplement or herb. It uses light rocking, gentle stretching, and self-movement exercises to encourage relaxation and easier movement, and many people find it pleasant and calming—but high-quality scientific evidence that it treats specific medical conditions is limited. It is generally low-risk, but you should check with your doctor before using it for any medical problem.

Not applicable (a hands-on bodywork and movement education method, not an herb or supplement) · In-person sessions with a certified practitioner (tablework) plus self-care movement exercises called Mentastics

An interaction check asks whether these two react with each other — it does not ask whether Trager Therapy is a good idea for someone in your situation. Here is what our Trager Therapy record says about it on its own.

Trager Therapy: dosing

Because Trager Therapy is a hands-on service and not a supplement, there is no standardized dose, milligram amount, or pill to take. Instead, it is delivered as sessions with a certified practitioner, often lasting around an hour, with the frequency varying from person to person.The number and timing of sessions are usually decided between you and your practitioner based on your goals and comfort.

From our Trager Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Trager Therapy monograph & all interactions
Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104

Medroxyprogesterone is used for different conditions depending on the product form. The injectable forms — including Depo-Provera and intramuscular medroxyprogesterone acetate injectable suspension — are used to prevent pregnancy. Depo-subQ Provera 104 (the subcutaneous injection) is also approved to manage pain associated with endometriosis.

The oral tablets — sold under the brand Provera and as generic medroxyprogesterone acetate tablets — treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance. The tablets are also used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking daily conjugated estrogens.

Most-Reported Side Effects for Medroxyprogesterone

From FAERS, the FDA’s public side-effect reporting system (60,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Meningioma 11,278 reports
Breast cancer 10,971 reports
Breast cancer female 10,184 reports
Breast cancer metastatic 1,943 reports
Nausea 1,449 reports
See full Medroxyprogesterone drug information
Keep checking

Other Drugs & Trager Therapy

Browse every other medication we’ve checked against Trager Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Trager Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Trager Therapy list.

See the full Trager Therapy interactions page
See every supplement checked against Medroxyprogesterone, ranked by severity
Evidence & sources

Trager Therapy References

The 3 references that drive our Trager Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Foster KA, Liskin J, Cen S, et al.The Trager approach in the treatment of chronic headache: a pilot study. Altern Ther Health Med 2004;10:40-6.
  2. Duval C, Lafontaine D, Hebert J, et al. The effect of Trager therapy on the level of evoked stretch responses in patients with Parkinson's disease and rigidity. J Manipulative Physiol Ther 2002;25:455-64. PubMed
  3. Dyson-Hudson TA, Shiflett SC, Kirshblum SC, et al. Acupuncture and Trager psychophysical integration in the treatment of wheelchair user's shoulder pain in individuals with spinal cord injury. Arch Phys Med Rehabil 2001;82:1038-46. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Trager Therapy While Taking Medroxyprogesterone: Common Questions

Is it safe to have Trager Therapy while taking Medroxyprogesterone?
We do not list a known interaction between Trager Therapy and Medroxyprogesterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Medroxyprogesterone interact with any supplements?
Yes. Medroxyprogesterone has documented interactions with 139 supplements in our database — Trager Therapy is not one of them. The Medroxyprogesterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Trager Therapy monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone supplement interactions Every supplement checked against Medroxyprogesterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone and Trager Therapy?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.