Wine - Metronidazole, Tetracyline, Bismuth Subcitrate Potassium Interaction Details

There are multiple interactions reported between these two agents.

Interaction Details

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium is classified as belonging to the following category: Hepatotoxic Drugs

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.
Concomitant use of excessive amounts of alcohol with potentially hepatotoxic drugs can increase the risk of liver damage.

Interaction Rating

Major

Likelihood of Occurrence

Probable

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90.

Interaction Details

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium is classified as belonging to the following category: Metronidazole (Flagyl)

Concomitant use may cause a disulfiram-like reaction.
Although there is some disagreement over the likelihood of a disulfiram-like reaction with concomitant use of alcohol and metronidazole, prescribing materials recommend discontinuing alcohol intake during the use of metronidazole. In the US, it is recommended to discontinue alcohol during and for at least three days after therapy with metronidazole; in Canada, it is recommended to discontinue alcohol during and for at least 1 day after therapy with metronidazole.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Flagyl (metronidazole) prescribing information. Pfizer Labs. New York, NY, December 2021. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/012623s069lbl.pdf
Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187.
Flagyl (metronidazole) prescribing information [CANADA]. Odan Labs. Pointe-Claire, QC H9R 2Y6. January 2018. Available at: https://pdf.hres.ca/dpd_pm/00044072.PDF

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium Overview

Bismuth, metronidazole, and tetracycline is used along with other ulcer medications to treat duodenal ulcers. It is in a class of medications called antibacterial agents. It works by preventing the growth and spread of Helicobacter pylori bacteria, which often occurs with ulcers. Treating this infection keeps ulcers from coming back.

See More Information Regarding Bismuth, Metronidazole, and Tetracycline

Wine - More Interactions

Wine interacts with 896 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.