Herb & supplement monograph

Frostwort Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Frostwort

0 medications have a known interaction with Frostwort, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Frostwort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Frostwort combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Frostwort: Uses, Safety & Side Effects

The bottom line

Frostwort is a North American wildflower used in traditional and folk herbal medicine, mainly as an astringent for sore throats, diarrhea, and skin problems. There is very little modern scientific research to confirm that it works or to define a safe dose, so it should be used cautiously and only after talking with a healthcare professional.

Scientific name
Helianthemum canadense
Family
Cistaceae
Part used
Whole plant (leaves and aerial parts)
Common forms
Dried herb, tea (infusion), tincture, sometimes topical preparations
People commonly use it for
  • Sore throat and mouth irritation
  • Diarrhea
  • Skin conditions and ulcers (topical)
  • Scrofula (historical/traditional use)
  • General astringent tonic

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLimited data

There is very little modern safety data on frostwort in humans.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Frostwort is a small flowering plant native to North America, often found growing in dry, sandy, or rocky soils and open woodlands. It gets its unusual name from the frost-like crystals of ice that can form at the base of its stem in cold weather.

The plant has a long history in folk and traditional herbal medicine, especially among early North American settlers and some Indigenous traditions. People have used the dried plant as a tea, gargle, or tincture, and sometimes applied it to the skin.

Today frostwort is uncommon and is not a mainstream supplement. It is mostly of interest to people who study traditional herbalism rather than something widely sold or studied.

Uses & effectiveness

Frostwort has traditionally been used as an astringent, meaning it was thought to tighten tissues and reduce secretions. Common folk uses include sore throats, mouth and gum irritation, diarrhea, and skin sores or ulcers when applied externally.

It was also historically used for "scrofula" (a form of tuberculosis affecting the lymph nodes) and other chronic conditions, but these uses come from old herbal writings, not from modern medicine.

The evidence is very weak. There are essentially no well-designed human clinical trials showing that frostwort works for any condition. What we know comes from tradition and historical texts, not from rigorous research. Because of this, it should not be relied on to treat any medical problem.

How it works

Frostwort is believed to contain tannins and other plant compounds that give it astringent properties. Tannins can bind to proteins in tissues, which may help explain its traditional use for sore throats, diarrhea, and skin irritation.

It is important to understand that these proposed actions are based mostly on the general chemistry of astringent plants and historical observation, not on detailed modern laboratory or human studies of frostwort specifically. The exact active compounds and how they behave in the body are not well characterized.

Safety & precautions

Because frostwort has not been well studied in modern times, its safety is largely unknown. There is no reliable information about safe long-term use, appropriate doses, or potential toxicity.

People with chronic health conditions, children, and older adults should be especially cautious. Plants high in tannins can sometimes cause stomach upset, especially in larger amounts or with prolonged use.

Pregnancy and breastfeeding: There is no good safety information for these situations. To stay on the safe side, frostwort should be avoided during pregnancy and while breastfeeding.

Always talk with a pharmacist or doctor before using frostwort, especially if you take medications or have a medical condition.

Side effects

Reliable data on side effects is lacking. Based on its astringent, tannin-containing nature, possible effects could include stomach upset, nausea, or digestive irritation, particularly with strong preparations or frequent use.

As with any plant product, allergic reactions are possible. Stop use and seek medical care if you develop a rash, swelling, trouble breathing, or other signs of an allergic reaction.

Dosing

There is no established or standardized dose for frostwort. Traditional use varied widely and was not based on measured, tested amounts.

If you choose to use a frostwort product, follow the directions on the product label and do not exceed them. Because quality and strength can vary a lot between products, and because safety data is limited, it is best to check with a pharmacist or doctor before starting.

Pregnancy & Breastfeeding

Frostwort & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Frostwort & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 sources that drive our Frostwort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Frostwort: Common Questions

Does Frostwort interact with prescription medications?
We do not currently list any known drug interactions for Frostwort. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Frostwort interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Frostwort with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Frostwort interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Frostwort used for?
It has traditionally been used as an astringent for sore throats, mouth irritation, diarrhea, and skin sores. These are folk uses, and modern science has not confirmed that it works for any of them.
Is Frostwort safe to take?
Its safety is largely unknown because there is very little modern research. It's best to be cautious, use small amounts if at all, and talk with a healthcare professional first.
Can I use Frostwort while pregnant or breastfeeding?
No reliable safety information exists for these situations, so it is best to avoid Frostwort during pregnancy and breastfeeding.
How is Frostwort usually taken?
Traditionally it was used as a tea or gargle, as a tincture, or applied to the skin. There is no standardized dose, so follow the product label and check with a pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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