Frostwort Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Frostwort interacts with medications. The heart of this page is the interaction list — every drug Frostwort is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Frostwort is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Frostwort against your medication
Add one medicationDrugs that interact with Frostwort
0 medications have a known interaction with Frostwort, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Frostwort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Frostwort combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Frostwort: Uses, Safety & Side Effects
Frostwort is a North American wildflower used in traditional and folk herbal medicine, mainly as an astringent for sore throats, diarrhea, and skin problems. There is very little modern scientific research to confirm that it works or to define a safe dose, so it should be used cautiously and only after talking with a healthcare professional.
- Scientific name
- Helianthemum canadense
- Family
- Cistaceae
- Part used
- Whole plant (leaves and aerial parts)
- Common forms
- Dried herb, tea (infusion), tincture, sometimes topical preparations
- Sore throat and mouth irritation
- Diarrhea
- Skin conditions and ulcers (topical)
- Scrofula (historical/traditional use)
- General astringent tonic
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
There is very little modern safety data on frostwort in humans.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Frostwort is a small flowering plant native to North America, often found growing in dry, sandy, or rocky soils and open woodlands. It gets its unusual name from the frost-like crystals of ice that can form at the base of its stem in cold weather.
The plant has a long history in folk and traditional herbal medicine, especially among early North American settlers and some Indigenous traditions. People have used the dried plant as a tea, gargle, or tincture, and sometimes applied it to the skin.
Today frostwort is uncommon and is not a mainstream supplement. It is mostly of interest to people who study traditional herbalism rather than something widely sold or studied.
Uses & effectiveness
Frostwort has traditionally been used as an astringent, meaning it was thought to tighten tissues and reduce secretions. Common folk uses include sore throats, mouth and gum irritation, diarrhea, and skin sores or ulcers when applied externally.
It was also historically used for "scrofula" (a form of tuberculosis affecting the lymph nodes) and other chronic conditions, but these uses come from old herbal writings, not from modern medicine.
The evidence is very weak. There are essentially no well-designed human clinical trials showing that frostwort works for any condition. What we know comes from tradition and historical texts, not from rigorous research. Because of this, it should not be relied on to treat any medical problem.
How it works
Frostwort is believed to contain tannins and other plant compounds that give it astringent properties. Tannins can bind to proteins in tissues, which may help explain its traditional use for sore throats, diarrhea, and skin irritation.
It is important to understand that these proposed actions are based mostly on the general chemistry of astringent plants and historical observation, not on detailed modern laboratory or human studies of frostwort specifically. The exact active compounds and how they behave in the body are not well characterized.
Safety & precautions
Because frostwort has not been well studied in modern times, its safety is largely unknown. There is no reliable information about safe long-term use, appropriate doses, or potential toxicity.
People with chronic health conditions, children, and older adults should be especially cautious. Plants high in tannins can sometimes cause stomach upset, especially in larger amounts or with prolonged use.
Pregnancy and breastfeeding: There is no good safety information for these situations. To stay on the safe side, frostwort should be avoided during pregnancy and while breastfeeding.
Always talk with a pharmacist or doctor before using frostwort, especially if you take medications or have a medical condition.
Side effects
Reliable data on side effects is lacking. Based on its astringent, tannin-containing nature, possible effects could include stomach upset, nausea, or digestive irritation, particularly with strong preparations or frequent use.
As with any plant product, allergic reactions are possible. Stop use and seek medical care if you develop a rash, swelling, trouble breathing, or other signs of an allergic reaction.
Dosing
There is no established or standardized dose for frostwort. Traditional use varied widely and was not based on measured, tested amounts.
If you choose to use a frostwort product, follow the directions on the product label and do not exceed them. Because quality and strength can vary a lot between products, and because safety data is limited, it is best to check with a pharmacist or doctor before starting.
Frostwort & Pregnancy
Frostwort & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 sources that drive our Frostwort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Using Dietary Supplements Wisely — NIH NCCIH Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Frostwort: Common Questions
Does Frostwort interact with prescription medications?
How are Frostwort interactions rated?
Is it safe to take Frostwort with my medications?
Where does this Frostwort interaction information come from?
What is Frostwort used for?
Is Frostwort safe to take?
Can I use Frostwort while pregnant or breastfeeding?
How is Frostwort usually taken?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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