Herb & supplement monograph

Maple Syrup Diet Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Maple Syrup Diet

0 medications have a known interaction with Maple Syrup Diet, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Maple Syrup Diet. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Maple Syrup Diet combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Maple Syrup Diet: Uses, Safety & Side Effects

The bottom line

The Maple Syrup Diet (also called the Master Cleanse or Lemonade Diet) is a fad cleanse where you drink a maple syrup, lemon, water, and cayenne mixture instead of eating food for several days. There is no good scientific evidence that it 'detoxes' the body, and any weight lost is mostly water and is usually regained. It can be risky because it provides almost no protein, fat, vitamins, or minerals, so most people should avoid it.

Common forms
Liquid cleanse drink (a mix of maple syrup, lemon juice, water, and cayenne pepper)
People commonly use it for
  • Short-term weight loss
  • Body 'detox' or cleanse
  • Jump-starting a diet
  • Quick fasting program

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

It is a very-low-nutrient liquid fast that can cause nutrient deficiencies and other problems, especially if done for more than a day or two.

PregnancyPossibly Unsafe

During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used...

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

The Maple Syrup Diet is a fad cleanse, not an herb or supplement. It is closely related to the popular Master Cleanse or Lemonade Diet. People follow it by drinking a homemade mixture instead of eating solid food, usually for a few days up to about a week or two.

The drink is typically made from maple syrup, fresh lemon juice, water, and a pinch of cayenne pepper. The maple syrup provides most of the calories, while lemon and cayenne are added for flavor and are claimed to support "detox."

The diet gained fame because some celebrities used it for quick weight loss before events. It is marketed as a way to lose weight fast and "cleanse" or "detox" the body, but these claims are not backed by solid science.

How it works

The diet "works" for short-term weight loss in a simple way: it is a very-low-calorie liquid fast. By replacing all meals with a sweetened drink, you take in far fewer calories than usual, so your body uses stored energy and water, and the scale goes down.

The "detox" idea behind the diet is that lemon and cayenne help flush out toxins. This is a marketing claim, not a proven mechanism. Maple syrup does contain small amounts of minerals and antioxidant compounds, but a few days of drinking it does not provide a meaningful health benefit, and it is still mostly sugar.

Importantly, the drink supplies almost no protein, healthy fat, fiber, or most vitamins and minerals, which is why it is not a safe way to eat for long.

Effectiveness

Does Maple Syrup Diet work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Maple Syrup Diet, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Clinical research in overweight Korean women shows that following the maple syrup diet for 7 days improves body mass index, body fat percentage, and waist-hip ratio when compared with a control group following a normal diet. Women who followed the maple syrup diet using a lemon-flavored liquid in place of lemon juice experienced similar improvements to those using lemon juice. This suggests that any benefit from this diet is likely related to its severe calorie restriction.

Sources Ref 103140

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, a single day on this diet is unlikely to cause serious harm. But following it for several days or longer can be risky because it lacks protein and essential nutrients.

You should avoid or be especially careful with this diet if you:

  • Have diabetes or blood sugar problems (the drink is high in sugar and very low in protein)
  • Have kidney, liver, or heart disease
  • Take medications that need food, or that affect blood sugar, blood pressure, or fluids
  • Have a history of an eating disorder
  • Are a child, teen, or older adult

Pregnancy and breastfeeding: Avoid this diet. Severe calorie and nutrient restriction can harm a developing baby and can reduce breast milk supply. Pregnant and nursing people need steady, balanced nutrition.

Always talk to a pharmacist or doctor before starting any cleanse or fasting plan, especially if you have a health condition or take medicine.

Side effects

Because this diet is so low in calories and nutrients, common side effects include:

  • Hunger, fatigue, and weakness
  • Headaches and dizziness
  • Irritability and trouble concentrating
  • Nausea or stomach upset (the cayenne can irritate the stomach)
  • Diarrhea or loose stools, especially if laxatives are used as part of the plan

More serious problems can develop if the diet is followed for a long time, including dehydration, low blood sugar, electrolyte imbalances, muscle loss, and gallstones. Rapid weight loss and fluid shifts can be dangerous for some people. Stop the diet and seek medical care if you feel faint, have an irregular heartbeat, or feel very unwell.

Maple Syrup Diet: Reported Adverse Effects

Documented safety reports on Maple Syrup Diet from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is limited reliable information available about the adverse effects of the maple syrup diet. However, the maple syrup diet does not provide adequate nutrition and involves the consumption of large quantities of water. This can lead to electrolyte imbalances when used short-term and malnutrition when used long-term.

  1. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no medically established or recommended dose for the Maple Syrup Diet, because it is a fad cleanse rather than a proven treatment. Popular versions have people drink several glasses of the maple-lemon-cayenne mixture throughout the day in place of meals.

Health experts generally do not recommend this diet at all. If you are curious about it, do not follow it for an extended period, stay well hydrated, and check with a pharmacist or doctor first. A balanced, calorie-controlled eating plan is a far safer and more effective way to lose weight.

Pregnancy & Breastfeeding

Maple Syrup Diet & Pregnancy

Possibly Unsafe

During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as well as malnutrition when used long-term.

  1. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.

Maple Syrup Diet & Breastfeeding

Possibly Unsafe

During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as well as malnutrition when used long-term.

  1. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Maple Syrup Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH. Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women. Nutr Res. 2015 May;35(5):409-20. PubMed
  2. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Maple Syrup Diet: Common Questions

What is Maple Syrup Diet used for, and does it work?
People use Maple Syrup Diet for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Maple Syrup Diet interact with prescription medications?
We do not currently list any known drug interactions for Maple Syrup Diet. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Maple Syrup Diet interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Maple Syrup Diet with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Maple Syrup Diet interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is the Maple Syrup Diet?
It is a short-term liquid cleanse where you drink a mix of maple syrup, lemon juice, water, and cayenne pepper instead of eating food. It is closely related to the Master Cleanse or Lemonade Diet.
Does the Maple Syrup Diet really detox your body?
No. There is no good scientific evidence that it removes toxins. Your liver and kidneys already handle that job naturally every day.
Will I lose weight on the Maple Syrup Diet?
You may lose weight quickly because you are eating very few calories, but much of it is water and it is usually regained once you eat normally again.
Is the Maple Syrup Diet safe to do for a week or more?
It is risky for longer periods because it provides almost no protein, fat, or essential nutrients, which can lead to fatigue, dizziness, and nutrient deficiencies. Talk to a doctor before trying any extended cleanse.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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