Sour Cherry Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Sour Cherry interacts with medications. The heart of this page is the interaction list — every drug Sour Cherry is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Sour Cherry is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Sour Cherry against your medication
Add one medicationDrugs that interact with Sour Cherry
0 medications have a known interaction with Sour Cherry, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Sour Cherry. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Sour Cherry combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Sour Cherry: Uses, Safety & Side Effects
Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, joint and gout symptoms, and sleep. Early research is promising but limited, so it is not a proven treatment. It is generally well tolerated as a food, but talk to your pharmacist or doctor before using concentrated products.
- Scientific name
- Prunus cerasus
- Family
- Rosaceae
- Part used
- Fruit (and fruit juice or concentrate)
- Common forms
- Juice, concentrate, capsules, powder, dried fruit, extract
- Muscle soreness after exercise
- Gout and joint discomfort
- Sleep support
- Arthritis pain
- General antioxidant support
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally well tolerated as a food, but concentrated products are less studied.
When the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem...
Read the full pregnancy detailWhen the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Sour cherry comes from the Prunus cerasus tree, a relative of the sweet cherry. It is also commonly called tart cherry, and popular varieties include Montmorency and Morello. The trees grow in many temperate parts of the world, including Europe, the Middle East, and North America.
The deep-red fruit is naturally tart and is used in foods like pies, jams, and juices. As a supplement, it is most often sold as a juice, concentrate, powder, or capsule. People take it mainly for exercise recovery, joint and gout symptoms, and sleep.
How it works
Sour cherries are rich in plant compounds called anthocyanins and other polyphenols, which give the fruit its red color. In laboratory and animal studies, these compounds act as antioxidants and may help reduce inflammation.
Researchers think reduced inflammation and oxidative stress may explain the possible benefits for muscle recovery and joint comfort. Sour cherries also contain a small amount of melatonin, a hormone involved in the sleep cycle, which is the proposed reason for any sleep effects.
It is important to know that much of this is based on lab and animal research or small human studies, so these mechanisms are still being explored.
Does Sour Cherry work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Athletic performance
Most available research suggests that oral tart cherry modestly improves muscular strength and endurance when compared with control. However, most studies are limited by a high risk of selection bias.
Also studied for 13 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aromatase inhibitor-induced arthralgia
It is unclear if oral tart cherry is beneficial in patients with aromatase inhibitor-induced arthralgia (AIIA).
Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
It is unclear if oral tart cherry juice is beneficial in children with ADHD.
Insufficient Reliable Evidence To Rate Cognitive function
It is unclear if oral tart cherry improves cognitive function.
Insufficient Reliable Evidence To Rate Exercise-induced muscle soreness
Research on the use of oral tart cherry juice or supplements for the reduction of exercise-induced muscle soreness is conflicting.
Insufficient Reliable Evidence To Rate Exercise-induced respiratory infections
It is unclear if oral tart cherry juice reduces the risk of exercise-induced respiratory infections.
Insufficient Reliable Evidence To Rate Fibromyalgia
It is unclear if oral tart cherry improves symptoms in patients with fibromyalgia.
Insufficient Reliable Evidence To Rate Gout
It is unclear if oral tart cherry juice reduces symptoms of gout; research is conflicting.
Insufficient Reliable Evidence To Rate Hypertension
It is unclear if oral tart cherry juice reduces blood pressure; research is conflicting.
Insufficient Reliable Evidence To Rate Insomnia
Some small clinical studies suggest that oral tart cherry juice may modestly improve sleep and reduce insomnia. This effect might be due to the melatonin content in tart cherry juice. However, the evidence is conflicting.
Insufficient Reliable Evidence To Rate Metabolic syndrome
Oral tart cherry juice does not seem to improve cardiovascular or metabolic biomarkers in patients at risk for or with metabolic syndrome.
Insufficient Reliable Evidence To Rate Osteoarthritis
It is unclear if oral tart cherry juice is beneficial in patients with osteoarthritis.
Insufficient Reliable Evidence To Rate Range of motion
It is unclear if oral tart cherry is beneficial for range of motion.
Insufficient Reliable Evidence To Rate Ulcerative colitis
It is unclear if oral tart cherry is beneficial in patients with ulcerative colitis (UC).
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, sour cherry has a long history of safe use. Concentrated juices, powders, and capsules are less studied but appear generally well tolerated in short-term research.
People with diabetes should remember that cherry juice and concentrate can contain a lot of natural sugar. Those prone to kidney stones or who must watch potassium or oxalate intake may want to check with a healthcare provider.
For pregnancy and breastfeeding, eating the fruit is likely fine, but there is not enough safety information about concentrated supplement doses. To be cautious, avoid supplement-strength products unless your doctor or pharmacist approves.
Always tell your pharmacist or doctor about supplements you take, especially if you have an ongoing health condition.
Side effects
Sour cherry is usually well tolerated. The most common complaints are mild digestive symptoms, such as stomach upset, gas, or loose stools, especially with large amounts of juice or concentrate.
Because juice and concentrate are high in natural sugar and calories, drinking a lot regularly can add up. Allergic reactions are uncommon but possible in people sensitive to fruits in the rose (Rosaceae) family.
Sour Cherry: Reported Adverse Effects
Documented safety reports on Sour Cherry from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Tart cherry is generally well tolerated when consumed as whole fruit, juice concentrate, or seed extracts.
Most Common Adverse Effects:
Orally: Abdominal pain, asthenia, gastrointestinal upset, loose stools.
Allergic rhinitis (hay fever) Immunologic
One case of a skin reaction possibly due to cherry allergy after drinking a specific blend of tart cherry and apple juice (Sour cherry juice, Cherrypharm Inc.) has been reported.
Pain Gastrointestinal
In a clinical study, 29% of children who consumed 75 mL of tart cherry juice concentrate twice daily for 2 weeks reported abdominal pain. Two cases of loose stools after consumption of 90 whole tart cherries, and one case of gastrointestinal disturbance after drinking 10.5 ounces of tart cherry concentrate (Cherrish, Cherrish Corp.) twice daily for 14 days have been reported. One case of gastrointestinal symptoms after drinking a specific blend of tart cherry and apple juice (Sour cherry juice, Cherrypharm Inc.) has been reported.
- Soltanifar A, Moharreri F, Bakhtiari E, Hosseinpour A. The Effect of Adding Sour Cherry Concentrate to The Usual Treatment of Attention Deficit Hyperactivity Disorder In 6 To 12 Years Old Children. J Atten Disord 2023;27(2):214-219.
- Seymour EM, Warber SM, Kirakosyan A, et al. Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans. J Funct Food 2014;11:509-16.
- Elliot DL, Kuehl KS, Jones KD, Dulacki K. Using an eccentric exercise-testing protocol to assess the beneficial effects of tart cherry juice in fibromyalgia patients. Integ Med 2010;9(6):25-9.
- Schumacher HR, Pullman-Mooar S, Gupta SR, et al. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage 2013;21(8):1035-41.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official or standardized dose for sour cherry supplements. Studies have used different forms and amounts, including juice, concentrate, and capsules, so there is no single agreed-upon dose.
The best approach is to follow the directions on the product label and not exceed them. Because products vary widely in strength, it is smart to check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition.
Sour Cherry & Pregnancy
Sour Cherry & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Sour Cherry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Schumacher HR, Pullman-Mooar S, Gupta SR, et al. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage 2013;21(8):1035-41. PubMed
- Seymour EM, Warber SM, Kirakosyan A, et al. Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans. J Funct Food 2014;11:509-16. DOI
- Elliot DL, Kuehl KS, Jones KD, Dulacki K. Using an eccentric exercise-testing protocol to assess the beneficial effects of tart cherry juice in fibromyalgia patients. Integ Med 2010;9(6):25-9.
- Soltanifar A, Moharreri F, Bakhtiari E, Hosseinpour A. The Effect of Adding Sour Cherry Concentrate to The Usual Treatment of Attention Deficit Hyperactivity Disorder In 6 To 12 Years Old Children. J Atten Disord 2023;27(2):214-219. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Sour Cherry
406 brands in our database make a supplement containing Sour Cherry.
Supplement products with Sour Cherry
1,612 products in our database contain Sour Cherry. Open any to see its full ingredient list and every drug interaction we check.
Sour Cherry: Common Questions
What is Sour Cherry used for, and does it work?
Does Sour Cherry interact with prescription medications?
How are Sour Cherry interactions rated?
Is it safe to take Sour Cherry with my medications?
Where does this Sour Cherry interaction information come from?
Is Sour Cherry the same as tart cherry?
Does Sour Cherry juice really help with sleep?
Can Sour Cherry help with gout?
Is Sour Cherry safe to take every day?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Sour Cherry
A rotating sample of real supplements in our database that list Sour Cherry — open any to see its full ingredients and every drug interaction we check.
- Super Human Hulk Juice Sour Gummy Bear by Alpha Lion
- Raw One for Men by Garden of Life Vitamin Code
- Performance Elderberry & Zinc Lozenges by Nutra Sport
- AMPED Repair Tropical Punch Flavor by Isagenix
- Tart Cherry with CherryPURE by Life Extension
- Multivitamin Gummy Raspberry Lemonade Flavor by Cooper Complete
- Calcium Magnesium & Vitamin D3 Vanilla Frosting Flavor by Bluebonnet Rainforest Animalz
- Wholesome Greens Super Food French Vanilla Flavor by Wholesome Greens
- Core Daily 1 for Women 50+ by Country Life
- Kids Multivitamin Gummies by Mary Ruth's
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