Herb & supplement monograph

Sour Cherry Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Sour Cherry

0 medications have a known interaction with Sour Cherry, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Sour Cherry. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Sour Cherry combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Sour Cherry: Uses, Safety & Side Effects

The bottom line

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, joint and gout symptoms, and sleep. Early research is promising but limited, so it is not a proven treatment. It is generally well tolerated as a food, but talk to your pharmacist or doctor before using concentrated products.

Scientific name
Prunus cerasus
Family
Rosaceae
Part used
Fruit (and fruit juice or concentrate)
Common forms
Juice, concentrate, capsules, powder, dried fruit, extract
People commonly use it for
  • Muscle soreness after exercise
  • Gout and joint discomfort
  • Sleep support
  • Arthritis pain
  • General antioxidant support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated as a food, but concentrated products are less studied.

PregnancyLikely Safe

When the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem...

Read the full pregnancy detail
BreastfeedingLikely Safe

When the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Sour cherry comes from the Prunus cerasus tree, a relative of the sweet cherry. It is also commonly called tart cherry, and popular varieties include Montmorency and Morello. The trees grow in many temperate parts of the world, including Europe, the Middle East, and North America.

The deep-red fruit is naturally tart and is used in foods like pies, jams, and juices. As a supplement, it is most often sold as a juice, concentrate, powder, or capsule. People take it mainly for exercise recovery, joint and gout symptoms, and sleep.

How it works

Sour cherries are rich in plant compounds called anthocyanins and other polyphenols, which give the fruit its red color. In laboratory and animal studies, these compounds act as antioxidants and may help reduce inflammation.

Researchers think reduced inflammation and oxidative stress may explain the possible benefits for muscle recovery and joint comfort. Sour cherries also contain a small amount of melatonin, a hormone involved in the sleep cycle, which is the proposed reason for any sleep effects.

It is important to know that much of this is based on lab and animal research or small human studies, so these mechanisms are still being explored.

Effectiveness

Does Sour Cherry work?

Evidence overview · 14 uses evaluated
1 Possibly effective 13 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Most available research suggests that oral tart cherry modestly improves muscular strength and endurance when compared with control. However, most studies are limited by a high risk of selection bias.

Also studied for 13 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aromatase inhibitor-induced arthralgia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry is beneficial in patients with aromatase inhibitor-induced arthralgia (AIIA).

Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry juice is beneficial in children with ADHD.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry improves cognitive function.

Insufficient Reliable Evidence To Rate Exercise-induced muscle soreness
Rating & evidence shown verbatim from Natural Medicines

Research on the use of oral tart cherry juice or supplements for the reduction of exercise-induced muscle soreness is conflicting.

Insufficient Reliable Evidence To Rate Exercise-induced respiratory infections
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry juice reduces the risk of exercise-induced respiratory infections.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry improves symptoms in patients with fibromyalgia.

Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry juice reduces symptoms of gout; research is conflicting.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry juice reduces blood pressure; research is conflicting.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

Some small clinical studies suggest that oral tart cherry juice may modestly improve sleep and reduce insomnia. This effect might be due to the melatonin content in tart cherry juice. However, the evidence is conflicting.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Oral tart cherry juice does not seem to improve cardiovascular or metabolic biomarkers in patients at risk for or with metabolic syndrome.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry juice is beneficial in patients with osteoarthritis.

Insufficient Reliable Evidence To Rate Range of motion
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry is beneficial for range of motion.

Insufficient Reliable Evidence To Rate Ulcerative colitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tart cherry is beneficial in patients with ulcerative colitis (UC).

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a food, sour cherry has a long history of safe use. Concentrated juices, powders, and capsules are less studied but appear generally well tolerated in short-term research.

People with diabetes should remember that cherry juice and concentrate can contain a lot of natural sugar. Those prone to kidney stones or who must watch potassium or oxalate intake may want to check with a healthcare provider.

For pregnancy and breastfeeding, eating the fruit is likely fine, but there is not enough safety information about concentrated supplement doses. To be cautious, avoid supplement-strength products unless your doctor or pharmacist approves.

Always tell your pharmacist or doctor about supplements you take, especially if you have an ongoing health condition.

Side effects

Sour cherry is usually well tolerated. The most common complaints are mild digestive symptoms, such as stomach upset, gas, or loose stools, especially with large amounts of juice or concentrate.

Because juice and concentrate are high in natural sugar and calories, drinking a lot regularly can add up. Allergic reactions are uncommon but possible in people sensitive to fruits in the rose (Rosaceae) family.

Sour Cherry: Reported Adverse Effects

Documented safety reports on Sour Cherry from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Tart cherry is generally well tolerated when consumed as whole fruit, juice concentrate, or seed extracts.

Most Common Adverse Effects:

Orally: Abdominal pain, asthenia, gastrointestinal upset, loose stools.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

One case of a skin reaction possibly due to cherry allergy after drinking a specific blend of tart cherry and apple juice (Sour cherry juice, Cherrypharm Inc.) has been reported.

  1. Schumacher HR, Pullman-Mooar S, Gupta SR, et al. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage 2013;21(8):1035-41.
Pain Gastrointestinal

In a clinical study, 29% of children who consumed 75 mL of tart cherry juice concentrate twice daily for 2 weeks reported abdominal pain. Two cases of loose stools after consumption of 90 whole tart cherries, and one case of gastrointestinal disturbance after drinking 10.5 ounces of tart cherry concentrate (Cherrish, Cherrish Corp.) twice daily for 14 days have been reported. One case of gastrointestinal symptoms after drinking a specific blend of tart cherry and apple juice (Sour cherry juice, Cherrypharm Inc.) has been reported.

  1. Soltanifar A, Moharreri F, Bakhtiari E, Hosseinpour A. The Effect of Adding Sour Cherry Concentrate to The Usual Treatment of Attention Deficit Hyperactivity Disorder In 6 To 12 Years Old Children. J Atten Disord 2023;27(2):214-219.
  2. Seymour EM, Warber SM, Kirakosyan A, et al. Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans. J Funct Food 2014;11:509-16.
  3. Elliot DL, Kuehl KS, Jones KD, Dulacki K. Using an eccentric exercise-testing protocol to assess the beneficial effects of tart cherry juice in fibromyalgia patients. Integ Med 2010;9(6):25-9.
  4. Schumacher HR, Pullman-Mooar S, Gupta SR, et al. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage 2013;21(8):1035-41.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for sour cherry supplements. Studies have used different forms and amounts, including juice, concentrate, and capsules, so there is no single agreed-upon dose.

The best approach is to follow the directions on the product label and not exceed them. Because products vary widely in strength, it is smart to check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Sour Cherry & Pregnancy

Likely Safe

When the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem when used in medicinal amounts; avoid using.

Sour Cherry & Breastfeeding

Likely Safe

When the fruit is consumed in typical food amounts. There is insufficient reliable information available about the safety of tart cherry fruit or stem when used in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Sour Cherry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Schumacher HR, Pullman-Mooar S, Gupta SR, et al. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage 2013;21(8):1035-41. PubMed
  2. Seymour EM, Warber SM, Kirakosyan A, et al. Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans. J Funct Food 2014;11:509-16. DOI
  3. Elliot DL, Kuehl KS, Jones KD, Dulacki K. Using an eccentric exercise-testing protocol to assess the beneficial effects of tart cherry juice in fibromyalgia patients. Integ Med 2010;9(6):25-9.
  4. Soltanifar A, Moharreri F, Bakhtiari E, Hosseinpour A. The Effect of Adding Sour Cherry Concentrate to The Usual Treatment of Attention Deficit Hyperactivity Disorder In 6 To 12 Years Old Children. J Atten Disord 2023;27(2):214-219. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Sour Cherry

1,612 products in our database contain Sour Cherry. Open any to see its full ingredient list and every drug interaction we check.

CapraFlex by Mt. Capra Other (e.g. Tea Bag) 270 Caplet(s) View ingredients & interactions CapraFlex by Doctor's Choice Naturally Other (e.g. Tea Bag) 270 Caplet(s) View ingredients & interactions Carbon Recover Blueberry Pomegranate by Biolayne Powder 1 lbs · 447 Gram(s) View ingredients & interactions Carbon Recover Sour Apple by Biolayne Powder 1 lbs · 469.5 Gram(s) View ingredients & interactions Carbonated BCAA +Energy Blood Orange Lemonade by Celsius Liquid 12 Fluid Ounce(s) · 355 Milliliter(s) View ingredients & interactions Carbonated BCAA +Energy Tropical Twist by Celsius Liquid 12 Fluid Ounce(s) · 355 Milliliter(s) View ingredients & interactions Cardio Cherry Flavor by Life's Fortune Powder 16.8 Ounce(s) View ingredients & interactions Cardio Complete Mixed Berry Flavor by Doctor Recommended Supplements Powder 1.05 Pound(s) · 477 Gram(s) View ingredients & interactions Cardio Heart Health by Doctor Recommended Supplements Powder 16.82 Oz(s) · 477 Gram(s) View ingredients & interactions Cardio Heart Health by Doctor Recommended Supplements Powder 16.82 Ounce(s) · 477 Gram(s) View ingredients & interactions Cardio Mixed Berry Flavor by Life's Fortune Powder 16.8 Ounce(s) View ingredients & interactions Cardio-4 Super Antioxidants by Dr. Sinatra Capsule 60 Capsule(s) View ingredients & interactions CardioSentials Cherry Berry Flavor by Reliv Powder 11.64 Oz(s) View ingredients & interactions Catalyst by Nugenix Capsule 90 Capsule(s) View ingredients & interactions Celery Seed by JSAWELL Tablet Or Pill 60 Tablet(s) View ingredients & interactions Cell Tech Hyper-Build Blue Raspberry Blast by MuscleTech Performance Series Powder 1.06 lbs · 482 Gram(s) View ingredients & interactions CELL TECH HYPER-BUILD Extreme Fruit Punch by MuscleTech Performance Series Powder 1.07 lbs · 485 Gram(s) View ingredients & interactions CELL TECH HYPER-BUILD Icy Rocket Freeze by MuscleTech Performance Series Powder 1.08 lbs · 488 Gram(s) View ingredients & interactions CellularActive Methylcobalamin 1000 mcg Raspberry Flavor by Bluebonnet EarthSweet Chewables Tablet Or Pill 60 Chewable Tablet(s) View ingredients & interactions CellularActive Methylcobalamin 1000 mcg Raspberry Flavor by Bluebonnet EarthSweet Chewables Tablet Or Pill 60 Chewable Tablet(s) View ingredients & interactions CellularActive Methylcobalamin 5000 mcg Raspberry Flavor by Bluebonnet EarthSweet Chewables Tablet Or Pill 60 Chewable Tablet(s) View ingredients & interactions CellularActive Methylfolate 1000 mcg by Bluebonnet EarthSweet Chewables Tablet Or Pill 90 Chewable Tablet(s) View ingredients & interactions CellularActive Methylfolate 1000 mcg Raspberry Flavor by Bluebonnet EarthSweet Chewables Tablet Or Pill 90 Chewable Tablet(s) View ingredients & interactions CellularActive Methylfolate 1000 mcg Raspberry Flavor by Bluebonnet EarthSweet Chewables Tablet Or Pill 90 Chewable Tablet(s) View ingredients & interactions
Pharmacist Counseling Corner

Sour Cherry: Common Questions

What is Sour Cherry used for, and does it work?
People use Sour Cherry for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Sour Cherry for Athletic performance. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Sour Cherry interact with prescription medications?
We do not currently list any known drug interactions for Sour Cherry. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Sour Cherry interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Sour Cherry with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Sour Cherry interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Sour Cherry the same as tart cherry?
Yes. Sour Cherry, tart cherry, and varieties like Montmorello and Montmorency all refer to Prunus cerasus, which is more tart than the common sweet cherry.
Does Sour Cherry juice really help with sleep?
Sour cherries contain a small amount of natural melatonin, and a few small studies suggest it may modestly help sleep. The evidence is limited, so it is not a guaranteed sleep aid.
Can Sour Cherry help with gout?
Some early research suggests tart cherry may ease gout symptoms or lower uric acid, but this is not proven. It should not replace any gout medicine your doctor has prescribed.
Is Sour Cherry safe to take every day?
Eating the fruit or drinking moderate amounts of juice is generally fine for most people, but the juice is high in natural sugar. Check with your pharmacist before taking concentrated supplements daily.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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