Suma Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Suma interacts with medications. The heart of this page is the interaction list — every drug Suma is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Suma is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Suma against your medication
Add one medicationDrugs that interact with Suma
0 medications have a known interaction with Suma, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Suma. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Suma combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Suma: Uses, Safety & Side Effects
Suma is a South American root often marketed as a 'Brazilian ginseng' and used as an adaptogen for energy, stamina, and stress. Human evidence is very limited, and most claims come from traditional use and lab or animal studies. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a hormone-sensitive condition.
- Scientific name
- Pfaffia paniculata
- Family
- Amaranthaceae
- Part used
- Root
- Common forms
- Capsules, powder, tablets, tincture, tea
- General energy and vitality
- Adaptogen for stress
- Sexual health and libido
- Athletic performance
- Immune support
- Hormonal balance
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used in foods and supplements, but human safety data are limited.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Suma is a large, vine-like ground plant native to the rainforests of Central and South America, especially Brazil. The part used in supplements is the root.
It is sometimes called "Brazilian ginseng," but it is not a true ginseng and is not related to Asian or American ginseng. In traditional medicine, the root has long been used as a tonic to boost energy, support sexual health, and help the body handle stress.
Today Suma is sold as capsules, powders, tablets, tinctures, and teas, often labeled as an adaptogen — a term for herbs claimed to help the body resist physical and mental stress.
Uses & effectiveness
People use Suma for many reasons, including energy, stamina, sexual function, hormone balance, immune support, and recovery from illness or exercise. Most of these uses come from traditional practice, not from strong clinical research.
The scientific evidence in humans is very limited. Much of what is known comes from laboratory and animal studies, which cannot reliably predict how the herb works in people. There are no large, high-quality human trials that clearly show Suma is effective for any specific health condition.
Because the evidence is weak, Suma should be viewed as an unproven supplement. If you are considering it for a specific health problem, talk with a healthcare professional rather than relying on it instead of proven treatments.
How it works
Suma root contains a variety of natural compounds, including plant sterols (such as beta-ecdysterone and sitosterol), saponins sometimes called pfaffosides, amino acids, and minerals.
Researchers have suggested these compounds might have antioxidant, hormone-like, or immune-related effects. Ecdysterone, for example, has been studied for possible effects on muscle and performance.
It is important to know that these proposed mechanisms are mostly based on test-tube and animal research. It is not clear whether they produce meaningful effects in the human body at the amounts found in supplements.
Safety & precautions
Suma has a long history of use as a food and tonic, and it is generally considered reasonably well tolerated for short-term use. However, good-quality human safety studies are lacking, so its long-term safety is not well understood.
Because Suma may have hormone-like activity, people with hormone-sensitive conditions (such as certain breast, uterine, ovarian, or prostate conditions) should be cautious and check with a doctor first.
Inhaling Suma root powder has been linked to asthma-like breathing problems in some people, so handling the dust should be avoided by those with respiratory issues.
Pregnancy and breastfeeding: There is not enough reliable safety information, and the herb may have hormonal effects. To be safe, avoid Suma if you are pregnant, trying to become pregnant, or breastfeeding.
As with any supplement, quality varies between brands. Choose products from reputable manufacturers, and tell your pharmacist or doctor about anything you take.
Side effects
Reported side effects are not well documented because of limited research. Some people may experience mild stomach upset or digestive discomfort.
Breathing in the root powder may trigger asthma symptoms or allergic-type respiratory reactions in sensitive individuals. Allergic reactions are possible with any plant product.
If you develop a rash, trouble breathing, swelling, or other concerning symptoms, stop using Suma and seek medical care.
Suma: Reported Adverse Effects
Documented safety reports on Suma from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, suma seems to be well tolerated. No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted. When inhaled, powdered suma root can cause occupational asthma.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
- Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736.
Asthma Immunologic
When inhaled, suma root powder has caused allergic asthma symptoms in a single patient.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established standardized dose for Suma. Studies are too limited to recommend a specific amount, and product strengths vary widely.
If you choose to use it, follow the dosing directions on the product label and do not exceed them. A pharmacist can help you review a product and decide whether it is appropriate for you.
Start low, watch for any reactions, and stop if you notice side effects.
Suma & Pregnancy
Suma & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Suma monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
- Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Suma
129 brands in our database make a supplement containing Suma.
Supplement products with Suma
449 products in our database contain Suma. Open any to see its full ingredient list and every drug interaction we check.
Suma: Common Questions
Does Suma interact with prescription medications?
How are Suma interactions rated?
Is it safe to take Suma with my medications?
Where does this Suma interaction information come from?
What is Suma used for?
Is Suma the same as ginseng?
Is Suma safe to take?
Can I take Suma while pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Suma
A rotating sample of real supplements in our database that list Suma — open any to see its full ingredients and every drug interaction we check.
- Suma Alcohol Free by Herbal Terra
- Neuro Cogent by Amazon Therapeutics
- Gluten Free Greens by Catie's
- Androtrex by Global Healing Center
- Cal-Mag Zinc + D3 by Paradise Earth's Blend
- Suma by Amazon Therapeutics
- Super Immune Seasonal Wellness Multivitamin by Super Nutrition
- Female Reproductive Tonic Capsules by Dr. Morse's Cellular Botanicals
- Battle Fuel XT by MusclePharm
- One Daily Superfood Multi-Vitamin with Iron by Paradise Earth's Blend
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