Herb & supplement monograph

Wood Sorrel Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Wood Sorrel

0 medications have a known interaction with Wood Sorrel, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Wood Sorrel. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Wood Sorrel combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Wood Sorrel: Uses, Safety & Side Effects

The bottom line

Wood sorrel is a small, sour-tasting wild plant used in folk medicine and as a tangy edible green. There is very little modern research to support any health use, and its naturally high oxalic acid content means it should be used in small amounts. People with kidney problems, gout, or who are pregnant should be especially cautious.

Scientific name
Oxalis acetosella
Family
Oxalidaceae
Part used
Leaves and aerial parts
Common forms
Fresh leaves, tea, tincture, juice
People commonly use it for
  • Digestive upset
  • Mouth and throat soothing
  • Mild diuretic
  • Fever and thirst relief
  • Wound and skin care (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used as a food in small amounts, but its oxalic acid content makes large or frequent use risky.

PregnancyBest avoided

Not enough safety information; best avoided in medicinal amounts during pregnancy.

BreastfeedingPossibly Unsafe

When used orally; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Wood sorrel is a small, low-growing wild plant known for its heart-shaped, clover-like leaves and pleasant sour taste. The most commonly named species is Oxalis acetosella, though many related Oxalis plants share the same common name and similar properties.

It grows in woodlands, shady fields, and gardens across Europe, Asia, and North America. People have long nibbled the fresh leaves as a tart trail snack or added them to salads and soups for a lemony flavor.

In traditional folk medicine, wood sorrel was used as a cooling herb to ease thirst, calm an upset stomach, and soothe the mouth and throat. Today it is mostly enjoyed as a wild edible, with only limited medicinal use.

How it works

Wood sorrel's sour taste comes mainly from oxalic acid and oxalate salts. The plant also contains vitamin C, flavonoids, and other plant compounds that may have mild antioxidant activity.

Any proposed effects, such as a cooling or diuretic action, are based on traditional observation and laboratory ideas rather than well-designed studies. The same oxalic acid that gives the tart flavor is also the main reason for caution, because high amounts of oxalate can be harmful to the kidneys and can bind minerals like calcium.

Overall, the way wood sorrel might work in the body is not well understood, and most information is theoretical.

Effectiveness

Does Wood Sorrel work?

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Wood Sorrel, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Gingivitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wood sorrel for gingivitis, there is insufficient reliable information about the clinical effects of wood sorrel for this purpose.

Insufficient Reliable Evidence To Rate Scurvy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wood sorrel for scurvy, there is insufficient reliable information about the clinical effects of wood sorrel for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wood sorrel for wound healing, there is insufficient reliable information about the clinical effects of wood sorrel for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Eating small amounts of wood sorrel as a food is generally considered safe for most healthy people. The main concern is its high oxalic acid content, which can be a problem if eaten in large quantities or used regularly as a medicine.

People who should be especially careful or avoid it include those with:

  • Kidney stones or kidney disease, since oxalate can worsen stone formation.
  • Gout or other conditions affected by oxalic acid.
  • Rheumatoid arthritis or related joint problems, per traditional caution.

Pregnancy and breastfeeding: There is not enough information to know if wood sorrel is safe in medicinal amounts during these times. To be safe, avoid using it as a remedy if you are pregnant or breastfeeding. Always check with your pharmacist or doctor before using any new supplement.

Side effects

When eaten in small food amounts, wood sorrel rarely causes problems. Larger or frequent use can lead to side effects mostly linked to its oxalic acid content.

Possible side effects include:

  • Stomach upset, nausea, or irritation.
  • Reduced absorption of minerals such as calcium.
  • With heavy use, possible kidney irritation or increased risk of kidney stones.

Very large amounts of oxalic acid can be toxic. If you have any kidney concerns or notice symptoms like back pain, blood in the urine, or unusual cramping, stop using it and seek medical advice.

Wood Sorrel: Reported Adverse Effects

Documented safety reports on Wood Sorrel from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is currently a limited amount of information on the adverse effects of wood sorrel. A thorough evaluation of safety outcomes has not been conducted.

Most Common Adverse Effects:

Orally: Dermatitis, diarrhea, nausea, and polyuria.

Reports by condition
Dermatitis Dermatologic

Orally, consuming excessive amounts of wood sorrel can cause dermatitis. Wood sorrel contains oxalic acid, which is thought to be responsible for this adverse effect.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Diarrhea Gastrointestinal

Orally, consuming excessive amounts of wood sorrel can cause diarrhea, nausea, and other gastrointestinal symptoms. Wood sorrel contains oxalic acid, which is thought to be responsible for these adverse effects.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or standardized medicinal dose for wood sorrel. It has been used traditionally as fresh leaves, a tea, or a juice, but no reliable guidelines exist for how much is safe or effective.

Because of its oxalic acid content, it is wise to keep any use to small amounts and avoid taking it regularly. If you choose to use a commercial product, follow the directions on the label and ask a pharmacist or doctor first, especially if you have kidney problems or take other medicines.

Pregnancy & Breastfeeding

Wood Sorrel & Breastfeeding

Possibly Unsafe

When used orally; avoid using.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 references that drive our Wood Sorrel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Wood Sorrel: Common Questions

What is Wood Sorrel used for, and does it work?
People use Wood Sorrel for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Wood Sorrel interact with prescription medications?
We do not currently list any known drug interactions for Wood Sorrel. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Wood Sorrel interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Wood Sorrel with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Wood Sorrel interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Wood Sorrel used for?
It is mainly used as a tart wild edible green, and in folk medicine to ease thirst, soothe the stomach or mouth, and as a mild diuretic. None of these medicinal uses are proven by strong research.
Is Wood Sorrel safe to eat?
Small amounts as a food are generally fine for healthy people, but it contains oxalic acid, so it should not be eaten in large quantities or used regularly, especially by people with kidney problems or gout.
Can I use Wood Sorrel while pregnant or breastfeeding?
There is not enough safety information, so it is best to avoid using it as a medicine during pregnancy or breastfeeding. Check with your doctor or pharmacist first.
Why does Wood Sorrel taste sour?
Its sour, lemony flavor comes from oxalic acid and oxalate salts. This same compound is also the reason to limit how much you eat.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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