Medication interaction hub

What Supplements Interact with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Atropine, Hyoscyamine, Phenobarbital, Scopolamine brand names: Barbidonna No. 2, Belladonna Phenobarbital. Every interaction below applies to the brands too.

167 Interactions 11 Major 134 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atropine, Hyoscyamine, Phenobarbital, Scopolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atropine, Hyoscyamine, Phenobarbital, Scopolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Belladonna alkaloids with phenobarbital (Barbidonna, Belladonna Phenobarbital) pair a barbiturate sedative with drying antispasmodics for gut cramping, and that mix earns real caution around supplements. Eleven of the 167 ingredients on file carry a major rating, and most of the danger runs through added sedation: alcohol, kava, and dozens of other calming substances stack on the phenobarbital and, at the extreme, can depress breathing. St. John's wort works the opposite way, speeding phenobarbital's breakdown so the drug quietly loses effect.

Thirty more entries amplify the drying side, worsening dry mouth, blurred vision, constipation, and confusion, with the herb henbane the most serious of these. A smaller cluster of fibers and charcoals can keep the tablet from absorbing, so take them well apart from your dose. The 134 moderate and 22 minor listings mostly repeat these mechanisms at lower stakes, but anything that deepens drowsiness is the pairing to check with your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 134 Minor 22 No known interaction 1,285

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Atropine, Hyoscyamine, Phenobarbital, Scopolamine: Top Interactions at a Glance

The most significant Atropine, Hyoscyamine, Phenobarbital, Scopolamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 167 interacting ingredients — plus 1,285 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Atropine, Hyoscyamine, Phenobarbital, Scopolamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely St. John's Wort + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

St.

Read the full interaction Major Likelihood Likely Wine + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Atropine, Hyoscyamine, Phenobarbital, Scopolaminei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction
The complete list

Every Supplement Checked Against Atropine, Hyoscyamine, Phenobarbital, Scopolamine

All 1,452 ingredients in our database, ranked by severity — 167 with a Atropine, Hyoscyamine, Phenobarbital, Scopolamine interaction on file and 1,285 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Saffron with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Sage with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Sassafras with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Sceletium with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Selenium with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium might prolong the sedating effects of barbiturates.

Full Selenium + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Shepherd's Purse with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Skullcap with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Slippery Elm with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Spearmint with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Sweet Annie with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.

Full Sweet Annie + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Syrian Rue with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might decrease the effects of anticholinergic drugs.

Full Syrian Rue + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Tansy Ragwort with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in tansy ragwort...

Full Tansy Ragwort + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Tarragon with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Teazle with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Full Teazle + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Theacrine with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Thyme with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Full Thyme + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Tianeptine with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Toothed Clubmoss with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopol...

Full Toothed Clubmoss + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer

Can you take Tragacanth with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Atropine, Hyoscyamine, Phenobarbital, Scopolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atropine, Hyoscyamine, Phenobarbital, Scopolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atropine, Hyoscyamine, Phenobarbital, Scopolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atropine, Hyoscyamine, Phenobarbital, Scopolamine sits in 12 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Scopolamine (Transderm Scop) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Atropine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Atropine, Hyoscyamine, Phenobarbital, Scopolamine through this category.

Related: does Atropine, Hyoscyamine, Phenobarbital, Scopolamine deplete any nutrients?

Atropine, Hyoscyamine, Phenobarbital, Scopolamine has 13 reported nutrient associations in the research literature — see the Atropine, Hyoscyamine, Phenobarbital, Scopolamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atropine, Hyoscyamine, Phenobarbital, Scopolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atropine, Hyoscyamine, Phenobarbital, Scopolamine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Atropine, Hyoscyamine, Phenobarbital, Scopolamine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Atropine, Hyoscyamine, Phenobarbital, Scopolamine.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Atropine, Hyoscyamine, Phenobarbital, Scopolamine & Supplements: Common Questions

What supplements interact with Atropine, Hyoscyamine, Phenobarbital, Scopolamine?
Our database currently documents 167 ingredients with a known Atropine, Hyoscyamine, Phenobarbital, Scopolamine interaction (11 major, 134 moderate, 22 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 167. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Atropine, Hyoscyamine, Phenobarbital, Scopolamine supplement interactions are the most serious?
Focus on the major group: Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Atropine, Hyoscyamine, Phenobarbital, Scopolamine?
Plenty of supplements coexist fine with Atropine, Hyoscyamine, Phenobarbital, Scopolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Barbidonna No. 2 have the same supplement interactions as Atropine, Hyoscyamine, Phenobarbital, Scopolamine?
Yes — Barbidonna No. 2, Belladonna Phenobarbital all contain Atropine, Hyoscyamine, Phenobarbital, Scopolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Atropine, Hyoscyamine, Phenobarbital, Scopolamine deplete any vitamins or nutrients?
It might — Atropine, Hyoscyamine, Phenobarbital, Scopolamine has 13 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Atropine, Hyoscyamine, Phenobarbital, Scopolamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Atropine, Hyoscyamine, Phenobarbital, Scopolamine and my other medications?
This page covers Atropine, Hyoscyamine, Phenobarbital, Scopolamine against supplements and herbal ingredients. Checking Atropine, Hyoscyamine, Phenobarbital, Scopolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.