Medication interaction hub

What Supplements Interact with Mephenytoin?

Mephenytoin brand name: Mesantoin. Every interaction below applies to the brands too.

215 Interactions 9 Major 178 Moderate 28 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Mephenytoin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Mephenytoin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone taking mephenytoin (Mesantoin) for seizures should read this page with genuine care rather than as background noise. The biggest cluster of interactions piles sedation on top of a drug that already slows the nervous system, and alcohol, whether beer or wine, sits at the serious end of that group. A second pattern pulls the other way. St. John's wort can lower levels of phenytoin, mephenytoin's close relative, weakening the protection the drug is there to provide. For a seizure medicine, a level pushed too high and a level dragged too low are both real problems.

A smaller set of ingredients can stress the liver, which this drug also works hard, and a few charcoal and fiber products can keep an oral dose from absorbing properly unless spaced well apart. Of the 215 ingredients listed, nine carry a major rating, most from the sedation group, with 178 moderate and 28 minor making up the rest.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 178 Minor 28 No known interaction 1,237

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Mephenytoin: Top Interactions at a Glance

The most significant Mephenytoin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 215 interacting ingredients — plus 1,237 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Mephenytoin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Mephenytoini

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Mephenytoini

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely St. John's Wort + Mephenytoini

St.

Read the full interaction Major Likelihood Likely Wine + Mephenytoini

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Mephenytoini

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Mephenytoini

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Mephenytoin

All 1,452 ingredients in our database, ranked by severity — 215 with a Mephenytoin interaction on file and 1,237 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Mephenytoin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hound's Tongue with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers can increase the toxicity of the pyrrolizidine alkaloid (PA) constituents of hound's tongue.

Full Hound's Tongue + Mephenytoin answer

Can you take Khella with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Mephenytoin answer

Can you take Kratom with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Full Kratom + Mephenytoin answer

Can you take Kudzu with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Mephenytoin answer

Can you take Lemon Balm with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + Mephenytoin answer

Can you take Licorice with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.

Full Licorice + Mephenytoin answer

Can you take Ligandrol with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Mephenytoin answer

Can you take Limonene with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction.

Full Limonene + Mephenytoin answer

Can you take Lithium with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.

Full Lithium + Mephenytoin answer

Can you take Mace with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedati...

Full Mace + Mephenytoin answer

Can you take Magnolia with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.

Full Magnolia + Mephenytoin answer

Can you take Manchurian Thorn with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Mephenytoin answer

Can you take Marsh Labrador Tea with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Mephenytoin answer

Can you take Melatonin with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Mephenytoin answer

Can you take Motherwort with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Mephenytoin answer

Can you take Neem with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.

Full Neem + Mephenytoin answer

Can you take Niacin with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Mephenytoin answer

Can you take Noni with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Mephenytoin answer

Can you take Nutmeg with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Mephenytoin answer

Can you take Oolong Tea with Mephenytoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oolong tea might reduce the effects of phenytoin and increase the risk for convulsions.

Full Oolong Tea + Mephenytoin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Mephenytoin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Mephenytoin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Mephenytoin sits in 11 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Mephenytoin through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Mephenytoin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Mephenytoin through this category.

Phenytoin (Dilantin) 23 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

23 of the supplement ingredients on this page reach Mephenytoin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Mephenytoin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Mephenytoin through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Mephenytoin through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Mephenytoin through this category.

Mephenytoin (Mesantoin) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Mephenytoin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Mephenytoin through this category.

Phenytoin (Dilantin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Mephenytoin through this category.

Related: does Mephenytoin deplete any nutrients?

Mephenytoin has 13 reported nutrient associations in the research literature — see the Mephenytoin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Mephenytoin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Mephenytoin.

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Pharmacist Counseling Corner

Mephenytoin & Supplements: Common Questions

What supplements interact with Mephenytoin?
In our interaction database, 215 supplement and herbal ingredients have an interaction with Mephenytoin on file — 9 rated major, 178 moderate, and 28 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Siberian Cocklebur, St. John's Wort.
Which Mephenytoin supplement interactions are the most serious?
Focus on the major group: Beer, Siberian Cocklebur, St. John's Wort, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Mephenytoin?
That depends entirely on which supplement. The honest answer for Mephenytoin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Mesantoin have the same supplement interactions as Mephenytoin?
Yes — Mesantoin all contain Mephenytoin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Mephenytoin deplete any vitamins or nutrients?
It might — Mephenytoin has 13 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Mephenytoin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Mephenytoin and my other medications?
This page covers Mephenytoin against supplements and herbal ingredients. Checking Mephenytoin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.