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What Supplements Interact with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital brand names: Bellaphen-S, Spastrin, Phenarbal S, Duragal S, Bellamine-S, and others. Every interaction below applies to the brands too.

250 Interactions 11 Major 200 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

250 supplements and herbal ingredients have interactions with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital on file in the HelloPharmacist interaction database — 11 rated major, 200 moderate, and 39 minor. The most serious involve Beer, Grapefruit, St. John's Wort, Wine and 1,4-butanediol.

Our assessment: with 11 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital.

Major 11 Moderate 200 Minor 39 No known interaction 1,202

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital: Top Interactions at a Glance

The most significant Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely St. John's Wort + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

St.

Read the full interaction Major Likelihood Likely Wine + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbitali

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 250 with a Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Boneset with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Diosmin with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Calendula with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Deanol with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Eastern Red Cedar with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essenti...

Full Eastern Red Cedar + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Eleuthero with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Gamma-aminobutyric Acid (gaba) with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Gymnema with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Humann Superbeets Heart Chews with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Jequirity with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Mommy's Bliss Gripe Water with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Polypodium Leucotomos with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Pomegranate with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Red Clover with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Tangerine with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Theanine with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Full Theanine + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Beer with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Grapefruit with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take St. John's Wort with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer

Can you take Wine with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital through this category.

Related: does Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital deplete any nutrients?

Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital has 42 reported nutrient associations in the research literature — see the Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital & Supplements: Common Questions

What supplements interact with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?
In our interaction database, 250 supplement and herbal ingredients have an interaction with Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital on file — 11 rated major, 200 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, St. John's Wort.
Which Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital supplement interactions are the most serious?
The 11 major-rated combinations — led by Beer, Grapefruit, St. John's Wort, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?
That depends entirely on which supplement. The honest answer for Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Bellaphen-S have the same supplement interactions as Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital?
Yes — Bellaphen-S, Spastrin, Phenarbal S, Duragal S, Bellamine-S and other brands all contain Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital deplete any vitamins or nutrients?
It might — Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital has 42 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital and my other medications?
This page covers Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital against supplements and herbal ingredients. Checking Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.