Medication interaction hub

What Supplements Interact with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Buprenorphine Hydrochloride, Naloxone Hydrochloride brand name: Bunavail. Every interaction below applies to the brands too.

199 Interactions 9 Major 151 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Buprenorphine Hydrochloride, Naloxone Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Buprenorphine Hydrochloride, Naloxone Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone taking buprenorphine with naloxone (Bunavail) for opioid dependence should give this list genuine weight. Nine of its 199 documented supplement interactions carry a major rating, and the most dangerous pattern is added sedation. Buprenorphine is itself an opioid, so anything else that quiets the nervous system, alcohol above all, can deepen drowsiness or slow breathing to a serious degree. Seventy-eight of the ingredients here work that way.

The other large group acts on the liver enzyme that clears buprenorphine. Grapefruit can raise its blood level while St. John's wort can lower it, and 121 ingredients touch that same pathway in one direction or the other. A smaller set of 17, including charcoal and bulking fibers, can blunt how much of an oral dose gets absorbed, so space those well apart. Most entries, 151 of them, rate moderate, but with breathing suppression at stake, get clear on the nine majors first.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 151 Minor 39 No known interaction 1,253

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Buprenorphine Hydrochloride, Naloxone Hydrochloride: Top Interactions at a Glance

The Buprenorphine Hydrochloride, Naloxone Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 199 interacting ingredients — plus 1,253 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Buprenorphine Hydrochloride, Naloxone Hydrochloride Combinations Today

The Buprenorphine Hydrochloride, Naloxone Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cat's Claw + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Beet + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Tangerine + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Possible Panax Ginseng + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Beer + Buprenorphine Hydrochloride, Naloxone Hydrochloridei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Buprenorphine Hydrochloride, Naloxone Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 199 with a Buprenorphine Hydrochloride, Naloxone Hydrochloride interaction on file and 1,253 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Buprenorphine Hydrochloride, Naloxone Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cat's Claw with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Beet with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Grapefruit with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Tangerine with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Panax Ginseng with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Albizia Julibrissin with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take American Elder with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Ashwagandha with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Astaxanthin with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Ayahuasca with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Bacopa with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Bay Leaf with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Berberine with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Beta-methylphenethylamine (bmpea) with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Biofeedback with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Bishop's Weed with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Bitter Almond with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Bitter Orange with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Black Pepper with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer

Can you take Black Seed with Buprenorphine Hydrochloride, Naloxone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Buprenorphine Hydrochloride, Naloxone Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Buprenorphine Hydrochloride, Naloxone Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Buprenorphine Hydrochloride, Naloxone Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Buprenorphine Hydrochloride, Naloxone Hydrochloride sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Naloxone (Narcan) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Buprenorphine Hydrochloride, Naloxone Hydrochloride through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Buprenorphine Hydrochloride, Naloxone Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Buprenorphine Hydrochloride, Naloxone Hydrochloride.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Buprenorphine Hydrochloride, Naloxone Hydrochloride-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Buprenorphine Hydrochloride, Naloxone Hydrochloride.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Buprenorphine Hydrochloride, Naloxone Hydrochloride & Supplements: Common Questions

What supplements interact with Buprenorphine Hydrochloride, Naloxone Hydrochloride?
Our database currently documents 199 ingredients with a known Buprenorphine Hydrochloride, Naloxone Hydrochloride interaction (9 major, 151 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 199. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Buprenorphine Hydrochloride, Naloxone Hydrochloride supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Buprenorphine Hydrochloride, Naloxone Hydrochloride?
Plenty of supplements coexist fine with Buprenorphine Hydrochloride, Naloxone Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Bunavail have the same supplement interactions as Buprenorphine Hydrochloride, Naloxone Hydrochloride?
Yes — Bunavail all contain Buprenorphine Hydrochloride, Naloxone Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Buprenorphine Hydrochloride, Naloxone Hydrochloride and my other medications?
This page covers Buprenorphine Hydrochloride, Naloxone Hydrochloride against supplements and herbal ingredients. Checking Buprenorphine Hydrochloride, Naloxone Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.