Medication interaction hub

What Supplements Interact with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate brand names: Tri Tannate, Histatan, R-Tannate, Tritan, R Tannamine, and others. Every interaction below applies to the brands too.

229 Interactions 10 Major 175 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

229 supplements and herbal ingredients have interactions with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate on file in the HelloPharmacist interaction database — 10 rated major, 175 moderate, and 44 minor. The most serious involve Grapefruit, Activated Charcoal, Ephedra, Henbane and Lithium.

Our assessment: with 10 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate.

Major 10 Moderate 175 Minor 44 No known interaction 1,223

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate: Top Interactions at a Glance

The Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate Combinations Today

The Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Rue + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Read the full interaction Moderate Likelihood Possible Grape + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full interaction Moderate Likelihood Probable Coffee Charcoal + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.

Read the full interaction Moderate Likelihood Possible Methylsynephrine + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

Methylsynephrine has cardiac stimulant effects.

Read the full interaction Moderate Likelihood Possible Moringa + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate

All 1,452 ingredients in our database, ranked by severity — 229 with a Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rue with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Grape with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Coffee Charcoal with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Methylsynephrine with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Moringa with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Indian Snakeroot with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects.

Full Indian Snakeroot + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Isopropylnorsynephrine with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascula...

Full Isopropylnorsynephrine + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Jimson Weed with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Full Jimson Weed + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Khat with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Khella with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Kratom with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndr...

Full Kratom + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take L-tryptophan with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Lemongrass with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Lentinan with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Licorice with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Light Therapy with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Lime with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Marjoram with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Melatonin with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer

Can you take Methoxylated Flavones with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate & Supplements: Common Questions

What supplements interact with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?
In our interaction database, 229 supplement and herbal ingredients have an interaction with Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate on file — 10 rated major, 175 moderate, and 44 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate supplement interactions are the most serious?
The 10 major-rated combinations — led by Grapefruit, Activated Charcoal, Ephedra, Henbane and Lithium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?
That depends entirely on which supplement. The honest answer for Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tri Tannate have the same supplement interactions as Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate?
Yes — Tri Tannate, Histatan, R-Tannate, Tritan, R Tannamine and other brands all contain Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate and my other medications?
This page covers Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate against supplements and herbal ingredients. Checking Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.