Medication interaction hub

What Supplements Interact with Dexchlorpheniramine?

Dexchlorpheniramine brand names: Polaramine, Polaramine Repetabs. Every interaction below applies to the brands too.

198 Interactions 6 Major 149 Moderate 43 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dexchlorpheniramine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dexchlorpheniramine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

An allergy antihistamine like dexchlorpheniramine (Polaramine) sounds mild, but its interaction list warrants genuine care, and six of the 198 entries carry a major rating. The biggest cluster, 121 ingredients, can raise or lower the drug's blood levels through the liver enzyme that breaks it down. Grapefruit pushes levels up while St. John's wort drives them down, and both rate major. Another 30 ingredients pile the same anticholinergic effects on top of the drug's own: more drowsiness, dry mouth, constipation, and confusion.

Smaller groups matter too. Twenty ingredients add serotonin activity, twenty can heighten sun sensitivity, and seventeen, activated charcoal among them, can blunt absorption of anything swallowed, so space those well apart from a dose. Most of the 149 moderate and 43 minor entries are manageable once you know which group a supplement belongs to, but the six majors are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 149 Minor 43 No known interaction 1,254

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Dexchlorpheniramine: Top Interactions at a Glance

The Dexchlorpheniramine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 198 interacting ingredients — plus 1,254 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Dexchlorpheniramine Combinations Today

The Dexchlorpheniramine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Seed + Dexchlorpheniraminei

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vaso...

Read the full interaction Major Likelihood Probable Henbane + Dexchlorpheniraminei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Moderate Likelihood Possible Black Pepper + Dexchlorpheniraminei

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Agar + Dexchlorpheniraminei

Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Read the full interaction Moderate Likelihood Possible Clove + Dexchlorpheniraminei

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Clubmoss + Dexchlorpheniraminei

Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Read the full interaction
The complete list

Every Supplement Checked Against Dexchlorpheniramine

All 1,452 ingredients in our database, ranked by severity — 198 with a Dexchlorpheniramine interaction on file and 1,254 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dexchlorpheniramine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + Dexchlorpheniramine answer

Can you take Henbane with Dexchlorpheniramine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Dexchlorpheniramine answer

Can you take Black Pepper with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Dexchlorpheniramine answer

Can you take Agar with Dexchlorpheniramine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Dexchlorpheniramine answer

Can you take Clove with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Dexchlorpheniramine answer

Can you take Lemongrass with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Dexchlorpheniramine answer

Can you take Lentinan with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Dexchlorpheniramine answer

Can you take Licorice with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Dexchlorpheniramine answer

Can you take Light Therapy with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Dexchlorpheniramine answer

Can you take Lime with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Dexchlorpheniramine answer

Can you take Marjoram with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Dexchlorpheniramine answer

Can you take Melatonin with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Dexchlorpheniramine answer

Can you take Methoxylated Flavones with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Dexchlorpheniramine answer

Can you take Methylene Blue with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Dexchlorpheniramine answer

Can you take Moringa with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Dexchlorpheniramine answer

Can you take Neem with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Dexchlorpheniramine answer

Can you take Nutmeg with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.

Full Nutmeg + Dexchlorpheniramine answer

Can you take Oregon Grape with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Dexchlorpheniramine answer

Can you take Padang Cassia with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Dexchlorpheniramine answer

Can you take Panax Ginseng with Dexchlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Dexchlorpheniramine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dexchlorpheniramine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dexchlorpheniramine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dexchlorpheniramine sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Dexchlorpheniramine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Dexchlorpheniramine through this category.

About Dexchlorpheniramine

Chlorpheniramine is an antihistamine used to relieve allergy and cold symptoms like sneezing, itchy eyes, and runny nose.

Generic name: Dexchlorpheniramine  ·  Brand names: Polaramine, Polaramine Repetabs.

See the full Chlorpheniramine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dexchlorpheniramine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dexchlorpheniramine.

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Pharmacist Counseling Corner

Dexchlorpheniramine & Supplements: Common Questions

What supplements interact with Dexchlorpheniramine?
Our database currently documents 198 ingredients with a known Dexchlorpheniramine interaction (6 major, 149 moderate, 43 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 198. The highest-ranked right now: Grapefruit, Activated Charcoal, Henbane.
Which Dexchlorpheniramine supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Activated Charcoal, Henbane, Lithium and Scopolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dexchlorpheniramine?
Plenty of supplements coexist fine with Dexchlorpheniramine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Polaramine have the same supplement interactions as Dexchlorpheniramine?
Yes — Polaramine, Polaramine Repetabs all contain Dexchlorpheniramine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dexchlorpheniramine and my other medications?
This page covers Dexchlorpheniramine against supplements and herbal ingredients. Checking Dexchlorpheniramine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Chlorpheniramine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.