Medication interaction hub

What Supplements Interact with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate brand name: Actiq. Every interaction below applies to the brands too.

223 Interactions 10 Major 174 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Actiq (oral transmucosal fentanyl citrate) is a very potent opioid used for breakthrough cancer pain, and the 223 supplements and herbs on this list call for real vigilance, with the 10 rated major the ones to understand first. Anything sedating is the biggest threat, since alcohol and similar depressant ingredients can deepen fentanyl's suppression of breathing, the mechanism behind fatal opioid overdoses. Another large cluster changes how the CYP3A4 enzyme clears fentanyl; grapefruit pushes levels up, St. John's wort pulls them down, and either direction is trouble with a drug this strong.

Most of the remaining 174 moderate and 39 minor entries nudge drug clearance more gradually. Twenty ingredients add serotonin activity, raising the chance of serotonin syndrome with an opioid, and a few charcoal and fiber products can block absorption of medicines taken by mouth and belong well apart from each dose. On a painkiller this potent, even one beer changes the math.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 174 Minor 39 No known interaction 1,229

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate: Top Interactions at a Glance

The Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 223 interacting ingredients — plus 1,229 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate Combinations Today

The Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cranberry + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Goldenseal + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Feverfew + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Gotu Kola + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Oregon Grape + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Read the full interaction Minor Likelihood Unlikely Gamma-aminobutyric Acid (gaba) + Fentanyl Citrate, Oral Transmucosal Fentanyl Citratei

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate

All 1,452 ingredients in our database, ranked by severity — 223 with a Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interaction on file and 1,229 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cranberry with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Goldenseal with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Feverfew with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.

Full Feverfew + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Gotu Kola with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Oregon Grape with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Spearmint with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Sulforaphane with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Sweet Annie with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Tarragon with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Terminalia with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Theacrine with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Thuja with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Thunder God Vine with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Tianeptine with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Tinospora Cordifolia with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Tragacanth with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Turmeric with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Uva Ursi with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Valerian with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer

Can you take Vitamin E with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Fentanyl 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate through this category.

About Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate

Fentanyl is a narcotic pain reliever used to treat sudden breakthrough pain in cancer patients already taking regular opioid medications.

Generic name: Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate  ·  Brand name: Actiq.

See the full Fentanyl drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate.

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Products that contain Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate & Supplements: Common Questions

What supplements interact with Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?
More than you might expect — 223 in total, though they are far from equal: 10 are rated major, 174 moderate, and 39 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?
Usually yes — most people on Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Actiq have the same supplement interactions as Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate?
Yes — Actiq all contain Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate and my other medications?
This page covers Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate against supplements and herbal ingredients. Checking Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fentanyl drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.