Medication interaction hub

What Supplements Interact with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Oxytetracycline, Phenazopyridine, Sulfamethizole brand name: Urobiotic. Every interaction below applies to the brands too.

161 Interactions 7 Major 134 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Oxytetracycline, Phenazopyridine, Sulfamethizole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Oxytetracycline, Phenazopyridine, Sulfamethizole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

161 supplements and herbal ingredients have interactions with Oxytetracycline, Phenazopyridine, Sulfamethizole on file in the HelloPharmacist interaction database — 7 rated major, 134 moderate, and 20 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Oleander and St. John's Wort.

Our assessment: with 7 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Oxytetracycline, Phenazopyridine, Sulfamethizole.

Major 7 Moderate 134 Minor 20 No known interaction 1,291

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Oxytetracycline, Phenazopyridine, Sulfamethizole: Top Interactions at a Glance

The most significant Oxytetracycline, Phenazopyridine, Sulfamethizole supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 161 interacting ingredients — plus 1,291 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Oxytetracycline, Phenazopyridine, Sulfamethizole + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Oxytetracycline, Phenazopyridine, Sulfamethizolei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Oxytetracycline, Phenazopyridine, Sulfamethizolei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Oxytetracycline, Phenazopyridine, Sulfamethizolei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Oleander + Oxytetracycline, Phenazopyridine, Sulfamethizolei

Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.

Read the full interaction Major Likelihood Probable St. John's Wort + Oxytetracycline, Phenazopyridine, Sulfamethizolei

St.

Read the full interaction Major Likelihood Probable Wine + Oxytetracycline, Phenazopyridine, Sulfamethizolei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Oxytetracycline, Phenazopyridine, Sulfamethizole

All 1,452 ingredients in our database, ranked by severity — 161 with a Oxytetracycline, Phenazopyridine, Sulfamethizole interaction on file and 1,291 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Oxytetracycline, Phenazopyridine, Sulfamethizole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bromelain with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bromelain might increase levels of tetracycline antibiotics.

Full Bromelain + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Danshen with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels of drugs cleared by p-glycoprotein.

Full Danshen + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Pectin with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.

Full Pectin + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Testolone with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Tragacanth with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Turmeric with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Uzara with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Full Uzara + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Vitamin A with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Wahoo with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Full Wahoo + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take White Pepper with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of p-glycoprotein substrates.

Full White Pepper + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Thyroid Extract with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Agar with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Algin with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Baikal Skullcap with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.

Full Baikal Skullcap + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Black Psyllium with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Blond Psyllium with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Carob with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Celery with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Devil's Claw with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Oxytetracycline, Phenazopyridine, Sulfamethizole answer

Can you take Grapefruit with Oxytetracycline, Phenazopyridine, Sulfamethizole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Oxytetracycline, Phenazopyridine, Sulfamethizole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Oxytetracycline, Phenazopyridine, Sulfamethizole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Oxytetracycline, Phenazopyridine, Sulfamethizole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Oxytetracycline, Phenazopyridine, Sulfamethizole sits in 7 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Tetracycline Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Oxytetracycline, Phenazopyridine, Sulfamethizole through this category.

Related: does Oxytetracycline, Phenazopyridine, Sulfamethizole deplete any nutrients?

Oxytetracycline, Phenazopyridine, Sulfamethizole has 11 reported nutrient associations in the research literature — see the Oxytetracycline, Phenazopyridine, Sulfamethizole nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Oxytetracycline, Phenazopyridine, Sulfamethizole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Oxytetracycline, Phenazopyridine, Sulfamethizole.

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Pharmacist Counseling Corner

Oxytetracycline, Phenazopyridine, Sulfamethizole & Supplements: Common Questions

What supplements interact with Oxytetracycline, Phenazopyridine, Sulfamethizole?
Our database currently documents 161 ingredients with a known Oxytetracycline, Phenazopyridine, Sulfamethizole interaction (7 major, 134 moderate, 20 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 161. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Oxytetracycline, Phenazopyridine, Sulfamethizole supplement interactions are the most serious?
The 7 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Oleander and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Oxytetracycline, Phenazopyridine, Sulfamethizole?
Plenty of supplements coexist fine with Oxytetracycline, Phenazopyridine, Sulfamethizole; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Urobiotic have the same supplement interactions as Oxytetracycline, Phenazopyridine, Sulfamethizole?
Yes — Urobiotic all contain Oxytetracycline, Phenazopyridine, Sulfamethizole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Oxytetracycline, Phenazopyridine, Sulfamethizole deplete any vitamins or nutrients?
It might — Oxytetracycline, Phenazopyridine, Sulfamethizole has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Oxytetracycline, Phenazopyridine, Sulfamethizole nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Oxytetracycline, Phenazopyridine, Sulfamethizole and my other medications?
This page covers Oxytetracycline, Phenazopyridine, Sulfamethizole against supplements and herbal ingredients. Checking Oxytetracycline, Phenazopyridine, Sulfamethizole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.