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Dietary supplement

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams Ingredients & Drug Interactions

by NutraBio

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glucomannan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: glucomannan, a soluble fiber extracted from konjac root, at 2,000 milligrams per capsule. The capsule itself is made from vegetable material (an inactive ingredient).

Glucomannan is a dietary fiber that absorbs water and becomes viscous (thick and gel-like) in your digestive system. It's the bulking and water-holding properties that give it potential benefits for digestive and metabolic health.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight management and digestive fiber support.
  • We looked for evidence on: Constipation, Diabetes, Hyperlipidemia, Metabolic syndrome, Obesity, appetite control — and 1 related terms.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Diabetes, Hyperlipidemia.
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

The evidence we hold shows glucomannan is possibly effective for constipation, diabetes, and high cholesterol (hyperlipidemia). For high blood pressure, there isn't enough reliable evidence to rate whether it works.

These ratings reflect what clinical trials have shown so far—some promise, but not definitive proof for all uses.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucomannan is generally well tolerated when you take it with plenty of water or liquid. The most common side effects are mild gut disturbances: abdominal pain, bloating, constipation, diarrhea, gas, nausea, or vomiting—especially if you take more than 3 grams daily.

Rare but serious concern: glucomannan can cause choking or blockage in your esophagus or intestines if swallowed dry or without enough liquid. This is why it's critical to take it with a full glass of water.

For pregnancy, there isn't enough safety data, so talk with your doctor first. Similarly, safety while breastfeeding isn't well established—ask your pharmacist or doctor before using.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check whether you're on any oral medications with your pharmacist. Glucomannan is rated Moderate for potentially slowing drug absorption across many medication types, including diabetes drugs like glyburide.

Spacing out doses may help, but get personalized advice—don't assume it's safe without asking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with constipation, blood sugar, or cholesterol if the evidence holds up for you—but its main risk is reducing absorption of your other medications. If you're on any oral drugs, check them against our interaction tool before starting.

Take it with plenty of water to avoid choking or blockage, and talk with your pharmacist or doctor if you're pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908514969
Net contents 90 V-Cap(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 66713
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Vegetable Capsule(s)
Maximum serving Sizes:
3 Vegetable Capsule(s)
Servings per container
30
UPC/BARCODE
649908514969
IngredientAmount% DV
Glucomannan2000 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Made in our GMP & FDA inspected facility

True label Full label disclosure

OU

Made in USA

General Statements

Weight management Fiber

30 servings

Vegetable Capsule

Pharmaceutical Grade. HPLC Lab Tested for Potency.

Manufactured in our GMP & FDA inspected facility

Formulation

Free of Harmful Impurities.

No fillers No excipients No additives

Vegetarian

Allergen free Non-GMO Gluten free BSE/TSE free Non-IRR/ETO

FDA Statement of Identity

Dietary Supplement

Formula

OU

Allergen Free

Brand IP Statement(s)

NUTRABIO WITHOUT COMPROMISE SINCE 1996

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.

General

51496-005 B20340-001

Suggested/Recommended/Usage/Directions

3 capsules 30-45 min. before meals Suggested Use: As a dietary supplement, take 3 capsules with water 30-45 minutes before meals, or as directed by your physician.

Glucomannan (Konjac Root Extract) is an expanding fiber and should be taken with sufficient drinking water.

Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of the reach of children.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Glucomannan (Konjac Root Extract) is an expanding fiber and should be taken with sufficient drinking water.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Vegetable Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Glucomannan

Interacts with
2,022 drugs
2000 mg per serving Form: Konjac root extract

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Glucomannan monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio Drug Interactions

Want to check YOUR meds against 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Glucomannan 2,022

Individual Drug Interactions

The ingredients in 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams interact with drugs. Each result below shows which ingredient is responsible. Glucomannan

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucomannan1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Glucomannan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio: Common Questions

Does 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams by NutraBio interact with any medications?
Yes. Based on its ingredients, 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Pure Glucomannan Konjac Root Extract 2000 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my medications?
Not without checking first. Glucomannan can reduce how much of an oral medication your body absorbs, which might make your drugs less effective. Show your pharmacist your medication list and ask about spacing doses apart—usually a few hours before or after glucomannan helps.
What side effects should I expect?
Most people get mild gut symptoms like bloating, gas, or loose stools, especially if you take more than 3 grams daily. The serious risk—and it's rare—is choking or intestinal blockage if you swallow it dry. Always take it with a full glass of water.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough data to know for sure. Talk with your doctor before using it during pregnancy or while nursing—they can weigh the potential benefit against what we don't yet know.
Does glucomannan actually help with constipation or high cholesterol?
The evidence says it's possibly effective for both constipation and high cholesterol, plus possibly effective for blood sugar. That means some studies show benefit, but it's not proven in everyone—results can vary.
How should I take this to avoid choking?
Always swallow it with a full glass of water or another liquid. Don't take it dry, and make sure it goes down completely. If you have trouble swallowing, ask your pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams label
Go deeper

The Full Monographs Behind 100% Pure Glucomannan Konjac Root Extract 2000 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

100% Pure Glucomannan Konjac Root Extract 2000 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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