No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

100% Pure L-Histidine 500 Milligrams Ingredients & Drug Interactions

by NutraBio

100% Pure L-Histidine 500 Milligrams label
See full label image
Capsule Category: Amino Acid/protein
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure L-Histidine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

100% Pure L-Histidine 500 Milligrams is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of 100% Pure L-Histidine 500 Milligrams by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-histidine, an amino acid your body uses to build proteins and support immune function. Each capsule delivers 500 milligrams.

The capsule itself is a vegetable capsule, which serves as the inactive container.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Histidine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Histidine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cholera — rated "Possibly Effective" (Natural Medicines).

L-histidine is possibly effective for cholera. For other uses — atopic dermatitis (eczema), kidney failure, and rheumatoid arthritis — the evidence isn't strong enough in our data to rate it one way or another.

That doesn't mean it won't help, just that we don't have reliable information yet.

The evidence, ingredient by ingredient Histidine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-histidine from food is generally well tolerated. The safety notes flag that higher supplement doses haven't been well studied, so the long-term safety profile at 500 milligrams daily isn't firmly established.

Pregnancy and lactation safety data shows it's likely safe during both. If you're pregnant or nursing and want to take this, it's worth a conversation with your doctor or pharmacist first to make sure it fits your situation.

Side effects, ingredient by ingredient Histidine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredient we could check in this product.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.

L-histidine might interest someone looking into amino acid supplementation or exploring support for cholera, though evidence for other uses isn't established yet. If you're pregnant, nursing, or taking any medications, check in with your pharmacist before starting — not because interactions are a concern, but because the long-term safety of this supplement dose needs individual evaluation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure L-Histidine 500 Milligrams, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908242299
Net contents 240 V-Cap(s)
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 51066
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure L-Histidine 500 Milligrams by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
2 Vegetable Capsule(s)
Servings per container
240
UPC/BARCODE
649908242299
IngredientAmount% DV
L-Histidine500 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

1-2 capsules 2x daily between meals Suggested Use: As a dietary supplement, take 1-2 servings up to twice daily between meals, or as directed by your physician.

Formula

KOSHER

ALLERGEN FREE

Kosher, Hypoallergenic, Non-GMO, Gluten Free and BSE/TSE Free.

Kosher, Hypoallergenic, Non-GMO, Gluten Free and BSE/TSE Free.

Formulation

ALLERGEN FREE ~ NON-GMO ~ GLUTEN FREE ~ BSE/TSE FREE

No fillers No excipients No additives

Free of Harmful Impurities.

Kosher, Hypoallergenic, Non-GMO, Gluten Free and BSE/TSE Free. No added sugars, salt, preservatives, salicylates, or artificial color, flavor or fragrance.

Precautions

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

People suffering from schizophrenia or bipolar (manic) depression should not take an L-Histidine supplement without the approval of their medical professional.

General Statements

Made in USA

Manufactured in a GMP & FDA inspected facility

Made in a GMP & FDA inspected facility

Pharmaceutical Free Form Amino Acid

Pharmaceutical Grade HPLC Lab Tested for Potency

240 servings 500 milligrams

Vegetable Capsule

Since 1996

Brand IP Statement(s)

Amino Therapy

Seals/Symbols

TRUE LABEL FULL LABEL DISCLOSURE

OU

FDA Statement of Identity

Dietary Supplement

Storage

STORE IN A COOL DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

24229-001 B20149-002

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure L-Histidine 500 Milligrams by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure L-Histidine 500 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure L-Histidine 500 Milligrams by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

L-Histidine

No known
interactions
500 mg per serving

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...

L-Histidine monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure L-Histidine 500 Milligrams by NutraBio Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in 100% Pure L-Histidine 500 Milligrams. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for 100% Pure L-Histidine 500 Milligrams, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Pure L-Histidine 500 Milligrams by NutraBio: Common Questions

Does 100% Pure L-Histidine 500 Milligrams by NutraBio interact with any medications?
We do not currently list a known interaction for the mapped ingredients in 100% Pure L-Histidine 500 Milligrams. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
100% Pure L-Histidine 500 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-histidine safe during pregnancy and breastfeeding?
The safety data we hold shows L-histidine is likely safe during both pregnancy and lactation. That said, it's always smart to run it by your doctor or pharmacist before starting any supplement while pregnant or nursing, especially since higher supplement doses haven't been studied as thoroughly as dietary amounts.
What is L-histidine supposed to do?
L-histidine is an amino acid your body uses to make proteins and support immune function. In our data, it's possibly effective for cholera. For other uses like eczema, kidney issues, or rheumatoid arthritis, there isn't enough reliable evidence yet to say whether it works.
Has this supplement been studied for eczema or arthritis?
L-histidine has been looked at for both atopic dermatitis (eczema) and rheumatoid arthritis, but the evidence we have isn't strong or clear enough to rate whether it actually helps. More research is needed.
Are there any side effects listed for L-histidine?
No adverse effects are documented in our data for L-histidine. That doesn't mean they can't happen — it means we don't have specific reports on file — but it's a good sign that trial data hasn't flagged major problems.
Is this supplement safe if I'm taking other medications?
No interactions are documented between L-histidine and medications in our data. That said, absence of documented interactions isn't a guarantee none exist, so if you're on any prescriptions, it's worth running them through our medication checker or asking your pharmacist.
Why does the label say to avoid this unless advised by a doctor?
The safety notes caution that while L-histidine from food is part of normal diet, the long-term safety of higher supplement doses — like the 500 milligrams in this capsule — hasn't been thoroughly studied. So it's recommended to talk to your doctor before starting, especially if you're using it long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure L-Histidine 500 Milligrams is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure L-Histidine 500 Milligrams label
Go deeper

The Full Monographs Behind 100% Pure L-Histidine 500 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph →
Sources

Sources & How We Checked

100% Pure L-Histidine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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