2-HOBA 100 mg Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking 2-HOBA 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
2-HOBA 100 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for heart and circulation health, blood sugar support, source of fiber and protein.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of 2-HOBA 100 mg by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: hobamine, which comes from buckwheat. Buckwheat has been studied for potential cardiovascular and metabolic support, though the evidence remains limited.
The capsule also holds two inactive ingredients — acacia gum and white rice flour — which help form and fill the capsule.
Does it work?
Couldn't assess
The evidence for hobamine from buckwheat is not yet established in the data we hold. Studies on cardiovascular disease, chronic venous insufficiency (poor circulation in the veins), diabetes, and diabetic eye disease all show insufficient reliable evidence to rate its effectiveness for any of these uses.
If you're considering this supplement for a specific health goal, it's worth talking through what the current evidence does and doesn't show.
How safe is it?
Well-documented data
Buckwheat is generally well tolerated when taken by mouth, though allergic reactions can happen in some people. Symptoms may include skin sensitization, allergic rhinitis (runny nose), asthma, conjunctivitis (pink eye), nausea, vomiting, or in rare cases anaphylaxis.
Occupational or household exposure to buckwheat dust or husks can also cause sensitization. Safety data on concentrated buckwheat supplements during pregnancy and breastfeeding is limited.
The facts note that while buckwheat as a food is likely fine, supplement doses haven't been well studied in these situations. Talk with your doctor or pharmacist before taking this if you're pregnant or nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That doesn't mean none exist — just that we have no monograph data showing them.
Run your medications through the tool on this page to be thorough.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
2-HOBA 100 mg is a single-ingredient buckwheat extract with no documented drug interactions. The evidence for its health benefits isn't yet established.
If you have a buckwheat allergy or suspect you might, avoid it. Otherwise, a conversation with your pharmacist can help you decide if it's a fit for what you're hoping to do.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 2-HOBA 100 mg, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003828259 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 332246 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 2-HOBA 100 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hobamine | 100 mg | -- |
Other ingredients: Acacia Gum, White Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Hobamine - TSI Health Sciences, Inc (TSI).
2-Hydroxybenzylamine 2-HOBA 100 mg per day
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended use: Adults. Take 2 capsules per day. Each capsule contains 50 mg of Hobamine.
Precautions
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.
Keep out of childrens' reach.
As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
Storage
Store away from direct light, heat and humidity.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
2-HOBA 100 mg by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 2-HOBA 100 mg by SuperSmart
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Hobamine
No knowninteractions
Buckwheat is a nutritious, naturally gluten-free seed that is high in fiber, protein, and antioxidants like rutin. As a food it can be part of a heart...
Hobamine monograph & interactionsOther (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.
2-HOBA 100 mg by SuperSmart Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in 2-HOBA 100 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for 2-HOBA 100 mg, from the product label.
SuperSmart
See all SuperSmart products- Name
- SN Worldwide Unipessoal, Lda
- Street Address
- Avenida Do Infante 66, Edificio Quinta Avenida 1 C
- City
- Funchal
- ZipCode
- 9000-015
2-HOBA 100 mg by SuperSmart: Common Questions
Does 2-HOBA 100 mg by SuperSmart interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to buckwheat?
Is it safe to take 2-HOBA during pregnancy or breastfeeding?
What is hobamine and what does it do?
Does this supplement have fillers?
Will this interact with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if 2-HOBA 100 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 2-HOBA 100 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
2-HOBA 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Buckwheat 12 references
- Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1. PubMed
- Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6. PubMed
- Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
- Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6. PubMed
- Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
- Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8. PubMed
- Ihme, N., Kiesewetter, H., Jung, F., Hoffmann, K. H., Birk, A., Muller, A., and Grutzner, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled c
- Archimowicz-Cyrylowska B and et al. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytother Res 1996;10(659):62. DOI
- Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2. PubMed
- De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9. PubMed
- Qiu J, Liu Y, Yue Y, Qin Y, Li Z. Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. Nutr Res. 2016 Dec;36(12):1392-1401. PubMed
- Li L, Lietz G, Seal C. Buckwheat and CVD risk markers: a systematic review and meta-analysis. Nutrients. 2018;10(5). pii: E619. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC