Interactions on record — worth a quick check against your medications. Based on 5 of 23 ingredients. Check your meds →
Dietary supplement

22 Reishis Ingredients & Drug Interactions

by Ron Teeguarden's Dragon Herbs

22 Reishis label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 22 Reishis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

22 Reishis is a dietary supplement by Ron Teeguarden's Dragon Herbs with 23 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 655 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Reishi Fruiting Body Extract, Wild, Siberian Chaga Fruiting Body Extract, Wild, Black Hoof Mushroom Fruiting Body Extract, Wild. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 22 Reishis by Ron Teeguarden's Dragon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with 22 Reishis by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 22 Reishis by Ron Teeguarden's Dragon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 23 active ingredients.
  • “Proprietary Wild Fruiting Body Extract Blend” is a proprietary blend — the label gives one combined amount (2.25 mL) without saying how much of each component you get.

This product contains 23 ingredients, most of them fruiting body extracts from various wild mushroom and fungal species. The checked active ingredients are Black Reishi, Green Reishi, Tibetan White Reishi, Bamboo Yellow Mushroom, Siberian Chaga, Black Hoof Mushroom, and Chinese Yew Mushroom.

The remaining ingredients — including Ice Man's Fungus, White Hoof Reishi, Spotty Brown Mushroom, Artist's Conk, multiple other Reishi varieties, and several others — are also listed as active extracts, though we hold limited or no interaction data for most of them. The inactive ingredients are water and grain alcohol, which serve as the liquid base.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Traditional mushroom blend for wellness and vitality.
  • We looked for evidence on: Stress, Insomnia, Psychological well-being, Chronic fatigue syndrome (CFS), Cancer-related fatigue, Aging — and 3 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer-related fatigue, Insomnia, Stress, Psychological well-being, and more.

For the ingredients we could check, the evidence is sparse. Black Reishi and Green Reishi are rated as possibly ineffective for lowering cholesterol (hyperlipidemia), and there's insufficient evidence to rate either for altitude sickness, Alzheimer disease, or athletic performance.

Chaga and Black Hoof Mushroom likewise have insufficient evidence for the conditions studied — cardiovascular disease, diabetes, COVID-19 (chaga), and COVID-19 (Black Hoof). We hold no effectiveness data for the remaining ingredients in this product.

The evidence, ingredient by ingredient Reishi Mushroom Bamboo Chaga Black Hoof Mushroom Yew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom extracts (Black, Green, and Tibetan White) are generally well tolerated short-term, but long-term safety isn't well studied. Common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset; rare effects include insomnia and headache.

Some people may have respiratory allergies to reishi spores, causing sore throat and runny nose. Chaga is generally used in foods and teas but has limited human safety data; excessive consumption has been linked to kidney failure due to high oxalate levels.

Black Hoof Mushroom safety in humans is limited. Chinese Yew is highly toxic and can cause sudden death through cardiac arrest — symptoms include severe abdominal pain, vomiting, weakness, trembling, arrhythmias, and collapse within 30 to 90 minutes.

During pregnancy, Reishi and Chaga lack enough safety data and should be avoided. Bamboo supplement safety in pregnancy is also uncertain; concentrated extracts are not recommended.

The same applies to breastfeeding: Reishi, Chaga, and Black Hoof Mushroom all lack sufficient safety information for nursing. Chinese Yew is unsafe in both pregnancy and breastfeeding.

Side effects, ingredient by ingredient Reishi Mushroom Bamboo Chaga Black Hoof Mushroom Yew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Bamboo, Reishi Mushroom, Chaga, Black Hoof Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 655 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before using this product, check with your pharmacist if you take blood pressure medications (antihypertensive drugs), blood thinners or antiplatelet drugs, diabetes medications, immunosuppressants, antithyroid drugs, or medications broken down by your liver via CYP1A2 or CYP2E1 pathways. Do not use this product if you take Chinese Yew — it is highly toxic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains a highly toxic ingredient (Chinese Yew) that can cause sudden death and should never be used. Even setting that aside, the Reishi, Chaga, and Bamboo extracts present documented interactions with blood pressure drugs, blood thinners, diabetes medications, and immunosuppressants.

If you take any prescription medication, talk with your pharmacist before considering this product — and be aware that yew toxicity is a reason to avoid it altogether.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 23 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 22 Reishis, straight from the product label.

Brand Ron Teeguarden's Dragon Herbs
Barcode (UPC) 679372000101
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 316759
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 22 Reishis by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.25 mL
Maximum serving Sizes:
9 mL
Servings per container
27
UPC/BARCODE
679372000101
IngredientAmount% DV
Ice Man's Fungus Fruiting Body Extract, Wild0 NP--
White Hoof Reishi Fruiting Body Extract, Wild0 NP--
Black Reishi Fruiting Body Extract, Wild0 NP--
Green Reishi Fruiting Body Extract, Wild0 NP--
Bamboo Yellow Mushroom Fruiting Body Extract, Wild0 NP--
Tibetan White Reishi Fruiting Body Extract, Wild0 NP--
Spotty Brown Mushroom Fruiting Body Extract, Wild0 NP--
Artist's Conk Fruiting Body Extract, Wild0 NP--
Red Bamboo Reishi Fruiting Body Extract, Wild0 NP--
Thin Cap Reishi Fruiting Body Extract, Wild0 NP--
Backward Stem Purple Reishi Fruiting Body Extract, Wild0 NP--
Red Reishi Fruiting Body Extract, Wild0 NP--
Golden Reishi Fruiting Body Extract, Wild0 NP--
Red Reishi Fruiting Body Extract, Wild, Stemless0 NP--
Purple Reishi Fruiting Body Extract, Wild0 NP--
Beehive Reishi Fruiting Body Extract, Wild0 NP--
Siberian Chaga Fruiting Body Extract, Wild0 NP--
Tiger Milk Reishi Fruiting Body Extract, Wild0 NP--
Black Hoof Mushroom Fruiting Body Extract, Wild0 NP--
Pine Needle Mushroom Fruiting Body Extract, Wild0 NP--
Coriolus Fruiting Body Extract, Wild0 NP--
Proprietary Wild Fruiting Body Extract Blend2.25 mL--
Chinese Yew Mushroom Fruiting Body Extract, Wild0 NP--
Antrodia Fruiting Body Extract, Wild0 NP--

Other ingredients: Water, Grain Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

A blend of 22 rare wild woody mushrooms used for centuries in Asia to provide all Three Treasures at an ultimate level only attainable from the Fungi Kingdom. Some are considered to be varieties of Reishi, others are considered to be powerful in their own ways.

Formulation

It is extracted by a special process that enhances its potency.

Super potency extract

General Statements

Dragon Drops

Seals/Symbols

Di Tao Certified Authentic Source

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: 3-12 squirts per day as desired or as directed by a health practitioner. Shake well before use.

Precautions

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

22 Reishis by Ron Teeguarden's Dragon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

22 Reishis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 22 Reishis by Ron Teeguarden's Dragon Herbs

These are the 23 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.25 mL Dosage formLiquid Servings per container27 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Wild Fruiting Body Extract Blend

2.25 mL per serving

Other (inactive) ingredients: Water, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

22 Reishis by Ron Teeguarden's Dragon Herbs Drug Interactions

Want to check YOUR meds against 22 Reishis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
655Drugs
655 Moderate

Ingredients driving the most interactions

Black Reishi Fruiting Body Extract, Wild 375
Siberian Chaga Fruiting Body Extract, Wild 327
Black Hoof Mushroom Fruiting Body Extract, Wild 308
Bamboo Yellow Mushroom Fruiting Body Extract, Wild 5

Individual Drug Interactions

The ingredients in 22 Reishis interact with 655 drugs. Click any drug to see the details.

4 of the 23 ingredients in 22 Reishis interact with drugs. Each result below shows which ingredient is responsible. Black Reishi Fruiting Body Extract, Wild Siberian Chaga Fruiting Body Extract, Wild Black Hoof Mushroom Fruiting Body Extract, Wild Bamboo Yellow Mushroom Fruiting Body Extract, Wild

Each ingredient & the kinds of drugs it affects

For each ingredient in 22 Reishis with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Reishi Fruiting Body Extract, Wild3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Black Reishi Fruiting Body Extract, Wild full monograph & interactions

Siberian Chaga Fruiting Body Extract, Wild3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Siberian Chaga Fruiting Body Extract, Wild full monograph & interactions

Black Hoof Mushroom Fruiting Body Extract, Wild3 drug types · 308 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP2E1 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black hoof mushroom might reduce the effects of immunosuppressant medications.
In animal research, polysaccharides from black hoof mushroom and black hoof mushroom extract stimulate immune responses.

Likelihood Possible Evidence D
Black Hoof Mushroom Fruiting Body Extract, Wild full monograph & interactions

Bamboo Yellow Mushroom Fruiting Body Extract, Wild1 drug type · 5 drugs

Antithyroid Drugs

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.
Animal research suggests that long-term consumption of bamboo shoot can decrease thyroid peroxidase activity, as well as levels of thyroxine (T4) and triiodothyronine (T3). This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Bamboo Yellow Mushroom Fruiting Body Extract, Wild full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 22 Reishis, from the product label.

Ron Teeguarden's Dragon Herbs

See all Ron Teeguarden's Dragon Herbs products
Name
Ron Teeguarden's Dragon Herbs
Street Address
P.O. Box 361459
City
Los Angeles
State
CA
ZipCode
90036
Phone Number
(888) 558-6642
Web Address
www.dragonherbs.com
Pharmacist Counseling Corner

22 Reishis by Ron Teeguarden's Dragon Herbs: Common Questions

Does 22 Reishis by Ron Teeguarden's Dragon Herbs interact with any medications?
Yes. Based on its ingredients, 22 Reishis has a known interaction with 655 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
22 Reishis contains 23 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Black Hoof Mushroom do?
We hold no established effectiveness rating for Black Hoof Mushroom in our data. It has been used in traditional medicine, but human research is limited.
Can I take this while pregnant?
No. The Reishi extracts, Chaga, and Bamboo in this product all lack enough safety data for pregnancy, so they should be avoided. More importantly, this product contains Chinese Yew, which is poisonous and must be avoided entirely during pregnancy.
Can I take this while breastfeeding?
No. Reishi, Chaga, and Black Hoof Mushroom all lack sufficient safety information for breastfeeding. Additionally, Chinese Yew is poisonous and must be avoided entirely while nursing.
Are there any common side effects from the Reishi in this product?
Yes. The most common side effects from Reishi extracts are dizziness, dry mouth, itching, nausea, rash, and stomach upset. Rare effects include insomnia and headache. Some people may also experience respiratory allergies to reishi spores, causing sore throat or runny nose.
Is there a problem with the yew ingredient?
Yes — Chinese Yew is highly toxic and can cause sudden death. It should never be used as a supplement or home remedy, and this ingredient alone is a reason to avoid this product.
What about the Chaga in here — is it safe?
Chaga is generally used in foods and teas, but human safety data are limited. Excessive consumption has been linked to kidney failure due to high oxalate content. You'd need to talk with your doctor about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 22 Reishis is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

22 Reishis label
Go deeper

The Full Monographs Behind 22 Reishis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Bamboo

Interacts with 5 drugs

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail, and bone support. Solid human evidence f...

Read the full Bamboo monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Black Hoof Mushroom

Interacts with 308 drugs

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory...

Read the full Black Hoof Mushroom monograph → Herb & supplement monograph

Yew

Yew is a highly poisonous plant, and nearly all parts can be deadly even in small amounts. It is famous mainly because pharmaceutical drugs like paclitaxel (Taxol) are made from yew compound...

Read the full Yew monograph →
Sources

Sources & How We Checked

22 Reishis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 53 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Bamboo 4 references
  1. Chandra AK, Ghosh D, Mukhopadhyay S, et al. Effect of bamboo shoot, Bambusa arundinacea (Retz.) Willd. on thyroid status under conditions of varying iodine intake in rats. Indian J Exp Biol 2004;42(8):781-786.
  2. Kitajima T. Contact allergy caused by bamboo shoots. Contact Dermatitis 1986;15(2):100-102. PubMed
  3. Sang-A-Gad P, Guharat S, Wananukul W. A mass cyanide poisoning from pickling bamboo shoots. Clin Toxicol (Phila). 2011 Nov;49(9):834-9. PubMed
  4. Satya S, Bal LM, Singhal P, Naik SN. Bamboo shoot processing: food quality and safety aspect (a review). Trends in Food Sci. Technol. 2010;21(4):181-9. DOI

See these in context on the Bamboo monograph →

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
  8. Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
  9. Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed

See these in context on the Chaga monograph →

Black Hoof Mushroom 6 references
  1. Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S., and Yoo, I. D. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) 1995;43(12):2105-2108. PubMed
  2. Matsuba, S., Matsuno, H., Sakuma, M., and Komatsu, Y. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid Based Complement Alternat Med 2008;5(1):85-90.
  3. Kim, G. Y., Roh, S. I., Park, S. K., Ahn, S. C., Oh, Y. H., Lee, J. D., and Park, Y. M. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003;26(10):1418-1423 PubMed
  4. Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed
  5. Oh, G. S., Lee, M. S., Pae, H. O., Kwon, J., Lee, S. S., Jeong, J. G., Shin, M. K., Kwon, T. O., and Chung, H. T. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 2
  6. Kim, G. Y., Lee, J. Y., Lee, J. O., Ryu, C. H., Choi, B. T., Jeong, Y. K., Lee, K. W., Jeong, S. C., and Choi, Y. H. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci B

See these in context on the Black Hoof Mushroom monograph →

Yew 17 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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  5. Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7. PubMed
  6. Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23. PubMed
  7. Maguchi, S. and Fukuda, S. Taxus cuspidata (Japanese yew) pollen nasal allergy. Auris Nasus Larynx 2001;28 Suppl:S43-S47. PubMed
  8. Willaert, W., Claessens, P., Vankelecom, B., and Vanderheyden, M. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing Clin.Electrophysiol. 2002;25(4 Pt 1):511-512.
  9. Yersin, B., Frey, J. G., Schaller, M. D., Nicod, P., and Perret, C. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann.Emerg.Med. 1987;16(12):1396-1397. PubMed
  10. de Vos FYFL, van Laarhoven HMW. Taxus baccata allergy in a breast cancer patient. Neth J Med. 2012;70(5):249-0.
  11. Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41. PubMed
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  13. Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987 PubMed
  14. Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
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  16. Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709. PubMed
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See these in context on the Yew monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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