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Dietary supplement

5-Hydroxy-Tryptophan (100 mg) Ingredients & Drug Interactions

by Priority One Nutritional Supplements

5-Hydroxy-Tryptophan (100 mg) label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 5-Hydroxy-Tryptophan (100 mg) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

5-Hydroxy-Tryptophan (100 mg) is a dietary supplement by Priority One Nutritional Supplements with 1 active ingredient. Its ingredients are commonly taken for low mood, sleep problems, anxiety.Based on those ingredients, 317 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Griffonia simplicifolia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Griffonia simplicifolia seed extract, a plant source of 5-hydroxy-tryptophan (5-HTP), a compound your body uses to make serotonin — a chemical messenger in your brain linked to mood and sleep. The capsule itself is vegetarian, and the formula includes rice chelate as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Griffonia Simplicifolia product and its label doesn't state a use — see Griffonia Simplicifolia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we have for Griffonia simplicifolia doesn't support a firm claim about whether it works for anxiety, depression, insomnia, diarrhea, or headache — the data is too limited. Before you expect results, talk with your pharmacist about what the current science shows for your particular reason for considering it.

The evidence, ingredient by ingredient Griffonia Simplicifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Griffonia simplicifolia is generally well tolerated in adults, though quality evidence is limited and side effects do occur. The most common ones are abdominal pain, anxiety, diarrhea, drowsiness, fatigue, and headache.

Gastrointestinal upset — nausea, vomiting, stomach pain, heartburn, and diarrhea — is frequently linked to 5-HTP at any dose. Rarely, 5-HTP has been tied to mood changes like euphoria, hypomania, anxiety, and aggressiveness.

There isn't enough safety data to recommend this product during pregnancy or while breastfeeding. If you're pregnant or nursing, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Griffonia Simplicifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Griffonia Simplicifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 317 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on antidepressants, tramadol or other pain relievers like meperidine or pentazocine, MAOIs, dextromethorphan cough medicine, carbidopa for Parkinson's, or any CNS depressants like sedatives or sleeping pills. All carry a documented risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to you if you're interested in a plant-based 5-HTP source, but the evidence for its effectiveness is not yet established. The major caution is its interaction with antidepressants and other serotonin-related medications — if you're on any prescription, check it with us first.

Talk to your pharmacist about whether it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 5-Hydroxy-Tryptophan (100 mg), straight from the product label.

Brand Priority One Nutritional Supplements
Barcode (UPC) 815354020006
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235578
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
815354020006
IngredientAmount% DV
Griffonia simplicifolia100 mg--

Other ingredients: Rice Chelate, Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Recommendations: Take one (1) capsule daily or as directed by your physician.

Storage

Keep container tightly closed, store in a cool, dry place.

Formulation

Contains no preservatives. Bisphenol-A (BPA) & Phthalate Free

Vegetarian formulation

Non-GMO

Seals/Symbols

GMP Certified

General Statements

Priority One Nutritional Supplements Inc since 1988

For professional use only.

FDA Statement of Identity

A Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

5-Hydroxy-Tryptophan (100 mg) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Griffonia simplicifolia

Interacts with
317 drugs
100 mg per serving Form: L-5-Hydroxytryptophan

Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin. Some peop...

Griffonia simplicifolia monograph & interactions

Other (inactive) ingredients: Rice Chelate, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements Drug Interactions

Want to check YOUR meds against 5-Hydroxy-Tryptophan (100 mg)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
317Drugs
317 Moderate

Ingredients driving the most interactions

Griffonia simplicifolia 317

Individual Drug Interactions

The ingredients in 5-Hydroxy-Tryptophan (100 mg) interact with 317 drugs. Click any drug to see the details.

1 of the 1 ingredient in 5-Hydroxy-Tryptophan (100 mg) interact with drugs. Each result below shows which ingredient is responsible. Griffonia simplicifolia

Each ingredient & the kinds of drugs it affects

For each ingredient in 5-Hydroxy-Tryptophan (100 mg) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Griffonia simplicifolia8 drug types · 317 drugs

Antidepressant Drugs

Theoretically, taking Griffonia simplicifolia seed extract with antidepressant drugs might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with antidepressant drugs increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Carbidopa (Lodosyn)

Theoretically, taking Griffonia simplicifolia seed extract with carbidopa might increase the risk of serotonergic and other adverse effects.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with carbidopa increases the risk of serotonergic adverse effects, scleroderma-like skin reactions, hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.
Griffonia simplicifolia seed extract contains 5-HTP. In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Dextromethorphan (Robitussin Dm, Others)

Theoretically, taking Griffonia simplicifolia seed extract with dextromethorphan might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with dextromethorphan increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Meperidine (Demerol)

Theoretically, taking Griffonia simplicifolia seed extract with meperidine might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with meperidine increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking Griffonia simplicifolia seed extract with MAOIs might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with MAOIs increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Pentazocine (Talwin)

Theoretically, taking Griffonia simplicifolia seed extract with pentazocine drugs might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with pentazocine increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Tramadol (Ultram)

Theoretically, taking Griffonia simplicifolia seed extract with tramadol might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with tramadol increases the risk of serotonergic adverse effects.

Likelihood Possible Evidence D
Griffonia simplicifolia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 5-Hydroxy-Tryptophan (100 mg), from the product label.

Priority One Nutritional Supplements

See all Priority One Nutritional Supplements products
Name
Priority One Nutritional Supplements, Inc.
Pharmacist Counseling Corner

5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements: Common Questions

Does 5-Hydroxy-Tryptophan (100 mg) by Priority One Nutritional Supplements interact with any medications?
Yes. Based on its ingredients, 5-Hydroxy-Tryptophan (100 mg) has a known interaction with 317 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
5-Hydroxy-Tryptophan (100 mg) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is 5-HTP, and what does this supplement do?
5-HTP (5-hydroxy-tryptophan) is a compound your body makes naturally and uses to produce serotonin, a brain chemical involved in mood and sleep. This product provides 5-HTP from Griffonia simplicifolia seed extract, but the evidence we hold doesn't yet confirm it works for anxiety, depression, insomnia, diarrhea, or headache.
What are the most common side effects?
The most frequent ones are abdominal pain, anxiety, diarrhea, drowsiness, fatigue, and headache. Gastrointestinal issues like nausea, vomiting, stomach pain, and heartburn are commonly tied to 5-HTP specifically. Rarely, mood changes such as hypomania or aggressiveness have been reported.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to recommend it during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in these situations.
Does this product contain any fillers?
The formula includes rice chelate and a vegetarian capsule as inactive ingredients alongside the active Griffonia simplicifolia extract.
I'm on an antidepressant. Is this supplement safe for me?
No — antidepressants are documented to interact with this product and raise the risk of serotonin syndrome and other serotonergic effects. Check with your pharmacist before starting, and do not combine them without professional guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

5-Hydroxy-Tryptophan (100 mg) label
Go deeper

The Full Monographs Behind 5-Hydroxy-Tryptophan (100 mg)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Griffonia Simplicifolia

Interacts with 317 drugs

Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin. Some people use it for mood, sleep, and appetite,...

Read the full Griffonia Simplicifolia monograph →
Sources

Sources & How We Checked

5-Hydroxy-Tryptophan (100 mg)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Griffonia Simplicifolia 22 references
  1. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
  2. U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
  3. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
  4. Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
  5. Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
  6. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  7. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  8. Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
  9. Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. PubMed
  10. den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
  11. Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr 2013;6:29-34. PubMed
  12. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76:109-17. PubMed
  13. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 1977;224:175-86. DOI
  14. Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25:327-9. PubMed
  15. De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985;29:239-48.
  16. Wyatt, R. J., Vaughan, T., Galanter, M., Kaplan, J., and Green, R. Behavioral changes of chronic schizophrenic patients given L-5- hydroxytryptophan. Science 9-22-1972;177(54):1124-1126. PubMed
  17. van Hiele LJ. l-5-Hydroxytryptophan in depression: the first substitution therapy in psychiatry? The treatment of 99 out-patients with 'therapy-resistant' depressions. Neuropsychobiology 1980;6:230-40. PubMed
  18. Pranzatelli, M. R., Tate, E., Huang, Y., Haas, R. H., Bodensteiner, J., Ashwal, S., and Franz, D. Neuropharmacology of progressive myoclonus epilepsy: response to 5- hydroxy-L-tryptophan. Epilepsia 1995;36(8):783-791. PubMed
  19. Trouillas P, Serratrice G, Laplane D, et al. Levorotatory form of 5-hydroxytryptophan in Friedreich's ataxia. Results of a double-blind drug-placebo cooperative study. Arch Neurol 1995;52:456-60. PubMed
  20. Pardo JV. Mania following addition of hydroxytryptophan to monoamine oxidase inhibitor. Gen Hosp Psychiatry 2012;34(1):102.e13-4. PubMed
  21. Lemaire PA, Adosraku RK. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia. Phytochem Anal 2002;13(6):333-7.
  22. Esposito M, Precenzano F, Sorrentino M, Avolio D, Carotenuto M. A medical food formulation of Griffonia simplicifolia/magnesium for childhood periodic syndrome therapy: an open-label study on motion sickness. J Med Food 2015;18(8):916-20.

See these in context on the Griffonia Simplicifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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