A.M.P.'D UP Ingredients & Drug Interactions
What is this page for?
First and foremost: checking A.M.P.'D UP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
A.M.P.'D UP is a dietary supplement by i-Prevail Supplements with 4 active ingredients. Its ingredients are commonly taken for muscle building and strength, bodybuilding 'prohormone' supplement, boosting androgen/dht levels.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against A.M.P.'D UP by i-Prevail Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with A.M.P.'D UP by i-Prevail Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of A.M.P.'D UP by i-Prevail Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
A.M.P.'D UP contains 4 active ingredients: Epiandrosterone, Tongkat Ali (Eurycoma longifolia root extract), Naringen, and Laxopure (a laxogenin-derived compound). These are combined with inactive ingredients — the capsule shell, dicalcium phosphate, and magnesium stearate — which serve as binding and flow agents.
Epiandrosterone and Tongkat Ali are both hormone-related compounds meant to support testosterone levels and athletic or sexual function, while Laxopure is a plant-derived steroid compound. Naringen is a citrus flavonoid.
The product positions itself as a performance and vitality support formula.
Does it work?
Moderate evidence
The evidence for A.M.P.'D UP's ingredients is limited. Tongkat Ali is rated possibly effective for sexual desire, but the other ingredients lack sufficient evidence to establish their benefit.
Epiandrosterone, for instance, shows insufficient reliable evidence for athletic performance, muscle strength, erectile dysfunction, sexual arousal, or obesity. Laxopure has no effectiveness data on file.
Because most of this product's claims lack solid evidence, talk with your doctor or pharmacist about whether it's right for your goals.
How safe is it?
Well-documented data
Epiandrosterone is a hormone-related supplement with limited safety data and real potential for androgenic side effects — meaning effects linked to male hormones, such as acne, mood changes, or hair growth. Tongkat Ali is generally tolerated short-term in studies, but long-term safety and product quality are uncertain.
Both ingredients carry risks if testosterone is pushed beyond normal ranges, including acne, insulin resistance, and liver stress. Laxopure has very limited human safety data and widely variable product quality.
Neither this product nor any of its ingredients should be used during pregnancy or while breastfeeding — there is insufficient or no safety data for each.
Meds to double-check
Moderate interaction found
Before you take A.M.P.'D UP, check with your doctor or pharmacist if you use propranolol or other beta-blockers — this product may reduce their effectiveness. Also confirm any testosterone replacement therapy, medications metabolized through your liver (CYP1A2, CYP2C19, or CYP2A6 substrates), or hormone-sensitive medications.
Altogether, these interactions span 248 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
A.M.P.'D UP is a hormone-support formula with considerable interaction potential and limited evidence of effectiveness. If you take propranolol, any blood-pressure or heart medications, testosterone therapy, or drugs your liver processes, you need to check this product against your medications before starting.
Anyone pregnant, breastfeeding, or with hormone-sensitive health conditions should talk with their doctor or pharmacist before considering it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about A.M.P.'D UP, straight from the product label.
| Brand | i-Prevail Supplements |
|---|---|
| Net contents | 0 Not Present |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 228497 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for A.M.P.'D UP by i-Prevail Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Naringen | 200 mg | -- |
| Epiandrosterone | 200 mg | -- |
| Tongkat Ali | 200 mg | -- |
| Laxopure | 75 mg | -- |
Other ingredients: Capsule Shell, Dicalcium Phosphate, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Andro Metabolite Protagonist
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
A.M.P.'D UP by i-Prevail Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in A.M.P.'D UP by i-Prevail Supplements
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Naringen
Epiandrosterone
No knowninteractions
Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic perfor...
Epiandrosterone monograph & interactionsTongkat Ali
Interacts with248 drugs
Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...
Tongkat Ali monograph & interactionsLaxopure
No knowninteractions
Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human resear...
Laxopure monograph & interactionsOther (inactive) ingredients: Capsule Shell, Dicalcium Phosphate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
A.M.P.'D UP by i-Prevail Supplements Drug Interactions
HelloPharmacist Interaction Report
A.M.P.'D UP by i-Prevail Supplements contains ingredients with documented interactions affecting a substantial number of medications.
The most serious concern is Tongkat Ali (Eurycoma longifolia), which moderately interacts with propranolol, a beta-blocker used for heart rate and blood pressure control — the herb can reduce propranolol's levels and effectiveness by as much as 29% in clinical studies.
Read the full breakdown — every affected drug type, severity by severity
Tongkat Ali also has minor interactions with several categories of drugs that your liver processes. These include CYP1A2, CYP2C19, and CYP2A6 substrates — the herb may theoretically raise their levels, though this effect hasn't been reported in humans yet.
Additionally, if you take testosterone replacement therapy or related medications, Tongkat Ali may further boost testosterone levels.
Epiandrosterone, a hormone-related ingredient in this product, was checked and has no documented interactions in our data. Naringen could not be checked — we hold no interaction data for it.
Because this product contains multiple active ingredients and affects such a wide range of drug types, run your exact medications through the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against A.M.P.'D UP?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in A.M.P.'D UP interact with 248 drugs. Click any drug to see the details.
1 of the 4 ingredients in A.M.P.'D UP interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali
Hydrochlorothiazide, PropranololInderide
How Hydrochlorothiazide, Propranolol interacts with A.M.P.'D UP — through 1 ingredient. Tap an ingredient for the detail:
Tongkat AliPropranolol (inderal), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
Read the full Tongkat Ali + Hydrochlorothiazide, Propranolol interactionPropranololAngilol, Bedranol SR, Beta Prograne, Half Beta Prograne, Half-Inderal LA, Inderal +6 more
How Propranolol interacts with A.M.P.'D UP — through 1 ingredient. Tap an ingredient for the detail:
Tongkat AliPropranolol (inderal), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
Read the full Tongkat Ali + Propranolol interactionPropranolol HydrochlorideHemangeol
How Propranolol Hydrochloride interacts with A.M.P.'D UP — through 1 ingredient. Tap an ingredient for the detail:
Tongkat AliPropranolol (inderal), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
Read the full Tongkat Ali + Propranolol Hydrochloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in A.M.P.'D UP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Tongkat Ali
Propranolol (Inderal)
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.
Cytochrome P450 2A6 (Cyp2A6) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.
Testosterone
Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.
Brand information
Manufacturer and brand details for A.M.P.'D UP, from the product label.
A.M.P.'D UP by i-Prevail Supplements: Common Questions
Does A.M.P.'D UP by i-Prevail Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
Does this product actually work for muscle or athletic performance?
What are the side effects I should watch for?
What is Tongkat Ali, and why is it in this product?
What's the difference between the active and inactive ingredients?
I take propranolol. Can I use this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind A.M.P.'D UP’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Epiandrosterone
Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic performance. There is very little high-quality...
Read the full Epiandrosterone monograph → Herb & supplement monographEurycoma Longifolia
Interacts with 248 drugsEurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....
Read the full Eurycoma Longifolia monograph → Herb & supplement monographLaxogenin
Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human research to show it actually works. Because pr...
Read the full Laxogenin monograph →Sources & How We Checked
A.M.P.'D UP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Epiandrosterone 1 reference
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Eurycoma Longifolia 4 references
- Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
- Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
- Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
- Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC