Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Activated Charcoal Ingredients & Drug Interactions

by GNC Herbal Plus

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Activated Charcoal is a dietary supplement by GNC Herbal Plus with 1 active ingredient. Its ingredients are commonly taken for poisoning and drug overdose (in emergency care), gas and bloating, upset stomach.Based on those ingredients, 2,027 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Activated Charcoal. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Activated Charcoal by GNC Herbal Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

GNC Herbal Plus Activated Charcoal is a single-ingredient product — one capsule contains activated charcoal, the active ingredient. The capsule itself is made from vegetable cellulose, with rice flour and calcium silicate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes natural relief of gas and absorbs toxins.
  • We looked for evidence on: Flatulence, Poisoning, Dyspepsia, bloating, upset stomach, detoxification.
  • The strongest evidence on file: Activated Charcoal is rated "Possibly Effective" for Poisoning (Natural Medicines).
  • Also on file: Activated Charcoal is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence.

Activated charcoal is possibly effective for poisoning. For other uses — including hyperphosphatemia (high phosphate levels in blood), wound healing, dyspepsia (indigestion), hangover, and high cholesterol — the evidence isn't established in the data we hold.

You may see these claims in marketing, but reliable evidence to rate them doesn't exist.

The evidence, ingredient by ingredient Activated Charcoal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Activated charcoal is generally well tolerated for short-term use, but it commonly causes constipation — the most frequent complaint, though usually temporary. You may also experience black stools, abdominal pain, bloating, or gas.

Rarely, it can cause gastrointestinal obstruction. Safety data for routine use in pregnancy is limited; the data rates it as possibly safe, but you should use it only under medical guidance if you're pregnant or nursing.

Little safety data exists overall, so check with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Activated Charcoal

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Activated Charcoal.
  • The most serious interaction on file is rated Major.
  • For scale: 2,028 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GNC Herbal Plus Activated Charcoal, double-check any oral medications you take — activated charcoal can reduce their absorption and effectiveness (Major severity). Also check any oral contraceptives you're on, as activated charcoal may lower their effectiveness (Moderate severity).

Avoid taking activated charcoal at the same time as alcohol, which reduces how well it works (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Activated charcoal may be considered for poisoning, but it's best used under medical supervision only. If you take any medications regularly, you must check them against this product first — its interactions are extensive and serious.

Talk with your pharmacist before starting, especially if you're on birth control, heart drugs, or any other prescription.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Activated Charcoal, straight from the product label.

Brand GNC Herbal Plus
Barcode (UPC) 048107113124
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18389
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Activated Charcoal by GNC Herbal Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
048107113124
IngredientAmount% DV
Activated Charcoal560 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

GNC HERBAL PLUS(R)

General Statements

NEW

ACTUAL SIZE

CODE 244300 ANG

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Promotes Natural Relief of Gas and Absorbs Toxins

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Formula

560 mg

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two capsules at mealtime.

Formulation

No Sugar, No Artificial Colors, No Artificial Flavors, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free.

Storage

Store in a cool, dry place.

See for yourself

Activated Charcoal by GNC Herbal Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Activated Charcoal by GNC Herbal Plus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Activated Charcoal

Interacts with
2,027 drugs
560 mg per serving

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings...

Activated Charcoal monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Activated Charcoal by GNC Herbal Plus Drug Interactions

Want to check YOUR meds against Activated Charcoal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,027Drugs
2,022 Major 5 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Activated Charcoal with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Activated Charcoal3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Activated Charcoal, from the product label.

GNC Herbal Plus

See all GNC Herbal Plus products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Activated Charcoal by GNC Herbal Plus: Common Questions

Does Activated Charcoal by GNC Herbal Plus interact with any medications?
Yes. Based on its ingredients, Activated Charcoal has a known interaction with 2,027 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Activated Charcoal contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will activated charcoal stop my birth control from working?
Activated charcoal may reduce how well oral contraceptives work, especially at higher doses, which could increase the risk of contraceptive failure. This is a real interaction, so talk with your pharmacist or doctor about timing or whether this product is right for you if you're on birth control.
What's the most common side effect I should expect?
Constipation is the most frequent complaint, though it's usually temporary. Black stools, abdominal pain, bloating, and gas are also common. Rarely, it can cause gastrointestinal obstruction, so if you feel severe pain or blocked intestines, seek medical attention.
Can I take this if I'm pregnant?
The safety data rates it as possibly safe in pregnancy, but it's not well studied for routine use. You should only use it under medical guidance if you're pregnant. Talk with your doctor or pharmacist about your specific situation before starting.
Why does activated charcoal interact with so many medications?
Activated charcoal works by binding to things in your digestive tract — that's how it does its job. But it doesn't know the difference between a poison and your medication, so it can bind to your drugs too and prevent your body from absorbing them, making those medications less effective.
Can I take this with alcohol?
Alcohol can reduce how well activated charcoal binds to things, so taking them together lessens the charcoal's effectiveness. It's best to avoid alcohol if you're using activated charcoal.
What is activated charcoal actually used for?
Activated charcoal is possibly effective for poisoning. For other uses like indigestion, hangover, high cholesterol, or wound healing, the reliable evidence isn't there in our data to back those claims up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Activated Charcoal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Activated Charcoal label
Sources

Sources & How We Checked

Activated Charcoal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Activated Charcoal 14 references
  1. Kaaja RJ, Kontula KK, Raiha A, Laatikainen T. Treatment of cholestasis of pregnancy with peroral activated charcoal. A preliminary study. Scand J Gastroenterol 1994;29:178-81.
  2. Anon. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin T
  3. Park GD, Spector R, Kitt TM. Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial. J Clin Pharmacol 1988;28:416-9. PubMed
  4. Hoegberg LC, Angelo HR, Christophersen AB, Christensen HR. Effect of ethanol and pH on the adsorption of acetaminophen (paracetamol) to high surface activated charcoal, in vitro studies. J Toxicol Clin Toxicol 2002;40:59-67. PubMed
  5. Brahmi N, Kouraichi N, Thabet H, Amamou M. Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. Am J Emerg Med 2006;24(4):440-3. PubMed
  6. Gude AB, Hoegberg LC, Angelo HR, Christensen HR. Dose-dependent adsorptive capacity of activated charcoal for gastrointestinal decontamination of a simulated paracetamol overdose in human volunteers. Basic Clin Pharmacol Toxicol 2010;106(5)406-10. PubMed
  7. Wananukul W, Klaikleun S, Sriapha C, Tongpoo A. Effect of activated charcoal in reducing paracetamol absorption at supra-therapeutic dose. J Med Assoc Thai 2010;93(10):1145-9.
  8. Wang Z, Cui M, Tang L, et al. Oral activated charcoal suppresses hyperphosphataemia in haemodialysis patients. Nephrology (Carlton) 2012;17(7):616-20. PubMed
  9. Wang X, Mondal S, Wang J, et al. Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects. Am J Cardiovasc Drugs 2014;14(2):147-54. PubMed
  10. Chyka PA, Seger D, Krenzelok EP, et al. Position paper: single-dose activated charcoal. Clin Toxicol (Phila) 2005;43(2):61-87. PubMed
  11. Chiew AL, Gluud C, Brok J, Buckley NA. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev 2018;2:CD003328. PubMed
  12. Elomaa K, Ranta S, Tuominen J, Lähteenmäki P. Charcoal treatment and risk of escape ovulation in oral contraceptive users. Hum Reprod. 2001;16(1):76-81. PubMed
  13. Gao Y, Wang G, Li Y, Lv C, Wang Z. Effects of oral activated charcoal on hyperphosphatemia and vascular calcification in Chinese patients with stage 3-4 chronic kidney disease. J Nephrol. 2019;32(2):265-72. PubMed
  14. Skov K, Graudal NA, Jürgens G. The effect of activated charcoal on drug exposure following intravenous administration: A meta-analysis. Basic Clin Pharmacol Toxicol 2021;128(4):568-578. PubMed

See these in context on the Activated Charcoal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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