Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Activated K2 Ingredients & Drug Interactions

by Vitamer Laboratories

Activated K2 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Activated K2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Activated K2 is a dietary supplement by Vitamer Laboratories with 3 active ingredients. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 18 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Choline Bitartrate, Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Activated K2 by Vitamer Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Activated K2 by Vitamer Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Activated K2 by Vitamer Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “GLA Activation Complex” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

This capsule contains three active ingredients. Choline bitartrate is a form of choline, a nutrient your body uses for brain function and cell signaling.

Vitamin K2 is one form of vitamin K, which your liver needs to make clotting proteins. The product also lists a GLA Activation Complex; we cannot break down that blend further from the information provided.

Four inactive ingredients — cellulose, vegetable cellulose capsule, magnesium stearate, and silica — are fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Calcium metabolism, cardiovascular and bone health.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Vascular calcification, Arterial stiffness, Bone mineralization, Fracture prevention.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).

The evidence here is mixed. Vitamin K2 is effective for correcting vitamin K deficiency and restoring clotting ability when it's lacking.

For bone health (osteoporosis), vitamin K is possibly effective — some support, but not conclusive. Choline's track record is less clear in our data.

It's listed as possibly ineffective for athletic performance, and we don't have enough reliable evidence to say whether it helps with age-related thinking problems, Alzheimer's disease, bronchitis, allergies, or liver problems from IV feeding. For the GLA Activation Complex, we hold no effectiveness information.

The evidence, ingredient by ingredient Vitamin K Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both choline and vitamin K2 are rated Likely Safe in pregnancy and lactation, though choline needs are higher while breastfeeding — talk to your doctor about the right dose. Vitamin K by mouth is generally well tolerated; the most common side effects are mild stomach upset, nausea, and diarrhea.

Choline is also generally well tolerated at normal doses, but high amounts (over 3.5 grams daily) can cause problems. At very high doses of 9 grams or more, choline can trigger nausea, vomiting, diarrhea, and a fishy body odor from how your gut breaks it down.

Most people won't reach those levels with a standard supplement, but it's worth knowing the upper limit exists.

Side effects, ingredient by ingredient Vitamin K Choline

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Choline, Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 18 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners like warfarin are the big one — vitamin K2 can reverse their effects (Major severity). Also flag atropine before starting, since choline might reduce how well it works in your brain (Minor severity).

Use the medication checker on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Activated K2 is straightforward if you're not on a blood thinner. If you take warfarin, you need to talk to your doctor or pharmacist first — vitamin K2 directly interferes with it.

Anyone on atropine should also check in. For everyone else, choline and vitamin K2 are generally well tolerated at supplement doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Activated K2, straight from the product label.

Brand Vitamer Laboratories
Barcode (UPC) 719985104312
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 67223
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Activated K2 by Vitamer Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
719985104312
IngredientAmount% DV
Choline Bitartrate0 NP--
Glutamic Acid0 NP--
Vitamin K275 mcg94%
GLA Activation Complex250 mg--

Other ingredients: Cellulose, Vegetable Cellulose Capsule, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Double Verified Gluten Free

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule with a meal or as directed by your health care professional.

Precautions

Keep out of reach of children.

General

VVL-104-60A

Formulation

Contains no artificial colors, flavors, or preservatives; no soy, wheat, gluten, milk, eggs, peanuts, tree nuts, crustacean shellfish or fish.

Suitable for vegans.

General Statements

Vitamin K2 is essential for its role in the activation of gamma-glutamyl-carboxylase (GLA).

We guarantee our supplements for potency and purity

Healthy heart and bones

Supports calcium metabolism

Formula

Our Activated K2 is made up of menaquinones (MK-4 through MK-10), and combined they play the critical role in calcium metabolism benefiting both cardiovascular and bone health. Because most K2 activity occurs in the liver, choline has been included to aid liver function, and glutamic acid to assist with the full activity of menaquinones.

Mixed Menaquinones with activated factors

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Activated K2 by Vitamer Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Activated K2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Activated K2 by Vitamer Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin K2

Interacts with
2 drugs
75 mcg per serving Form: mixed Menaquinones

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

GLA Activation Complex

250 mg per serving

Other (inactive) ingredients: Cellulose, Vegetable Cellulose Capsule, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Activated K2 by Vitamer Laboratories Drug Interactions

Want to check YOUR meds against Activated K2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
18Drugs
2 Major 16 Minor

Ingredients driving the most interactions

Choline Bitartrate 16
Vitamin K2 2

Individual Drug Interactions

The ingredients in Activated K2 interact with 18 drugs. Click any drug to see the details.

2 of the 3 ingredients in Activated K2 interact with drugs. Each result below shows which ingredient is responsible. Choline Bitartrate Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Activated K2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Activated K2, from the product label.

Vitamer Laboratories

See all Vitamer Laboratories products
Phone Number
1-888-710-0006
Pharmacist Counseling Corner

Activated K2 by Vitamer Laboratories: Common Questions

Does Activated K2 by Vitamer Laboratories interact with any medications?
Yes. Based on its ingredients, Activated K2 has a known interaction with 18 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Activated K2 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
Not without talking to your doctor first. Vitamin K2 in this product can weaken warfarin and similar blood thinners by reversing their effect. Your doctor may need to adjust your dose or monitor you more closely. Don't start it on your own.
Does choline actually improve memory or brain function?
We don't have enough reliable evidence to say whether choline helps with age-related thinking problems or Alzheimer's disease. For athletic performance, the evidence points to it being ineffective. The jury's still out on several other uses we have data for.
What are the side effects of choline at normal doses?
At typical supplement doses, choline is well tolerated with few side effects. At very high doses above 3.5 grams daily, you might notice a fishy body odor. At even higher doses (9+ grams), nausea, vomiting, and diarrhea become possible. A standard capsule shouldn't push you that high, but don't exceed the label dose.
Is vitamin K2 safe if I'm pregnant or breastfeeding?
Vitamin K2 is rated Likely Safe in pregnancy and lactation. Choline is also Likely Safe, though choline needs are higher while breastfeeding — ask your doctor or pharmacist what dose is right for you.
What does vitamin K2 actually do in this supplement?
Vitamin K2 helps your liver make clotting proteins, so it's effective at treating vitamin K deficiency and bleeding disorders. There's also some evidence it may help with bone strength, though that's not as firmly established.
What is the GLA Activation Complex?
The product lists a GLA Activation Complex, but we don't have a detailed breakdown of what that blend contains or what it's meant to do. You may want to contact the manufacturer directly for more specifics.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Activated K2 label
Go deeper

The Full Monographs Behind Activated K2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Activated K2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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