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Dietary supplement

Agnus Castus Complex Ingredients & Drug Interactions

by True Botanica

Agnus Castus Complex label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agnus Castus Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agnus Castus Complex is a dietary supplement by True Botanica with 1 active ingredient. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitex agnus-castus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agnus Castus Complex by True Botanica

Ask about any prescription or over-the-counter medication and we check it for interactions with Agnus Castus Complex by True Botanica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agnus Castus Complex by True Botanica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Agnus Castus Herb Extract” is listed as a grouped ingredient — the label gives one combined amount (0.50 mL) without saying how much of each component you get.

This product contains one active ingredient: vitex agnus-castus (also called chasteberry or Agnus Castus), delivered as a liquid herb extract. The inactive ingredients are water, glycerin, apple cider vinegar, salts, trace minerals, potassium sorbate, and citric acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Women's menstrual and hormonal health support.
  • We looked for evidence on: Premenstrual syndrome (PMS), Premenstrual dysphoric disorder (PMDD), Amenorrhea, Dysmenorrhea, Mastalgia, Fibrocystic breast disease — and 4 related terms.
  • The strongest evidence on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Possibly Effective" for Premenstrual syndrome (PMS).
  • Also on file: Vitex Agnus-castus is rated "Insufficient Reliable Evidence To Rate" for Amenorrhea, Fibrocystic breast disease, Hyperprolactinemia, Menopausal symptoms, and more.

Vitex agnus-castus is possibly effective for premenstrual syndrome (PMS) and mastalgia (breast pain related to the menstrual cycle). For other uses listed in the research — fractures, aging skin, premenstrual dysphoric disorder (PMDD), and anxiety — the evidence isn't established enough to rate it.

If you're considering this for PMS or breast pain, talk with your pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitex is generally well tolerated when taken short-term, but because it affects hormones, use it under guidance from your doctor or pharmacist. The most common side effects from oral use are diarrhea, fatigue, headache, insomnia, irregular menstruation, nausea, stomach pain, and vomiting.

Skin irritation, rashes, acne, and hair loss have also been reported. The safety data advises against taking vitex during pregnancy or while breastfeeding due to its possible hormonal effects and limited safety information in these situations.

Side effects, ingredient by ingredient Vitex Agnus-castus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitex Agnus-castus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take antipsychotic drugs, dopamine agonists (used for Parkinson's), metoclopramide (Reglan), oral contraceptives, or estrogens (including hormone replacement therapy). Vitex may theoretically interfere with how these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vitex may help with PMS or breast pain, but it's not for everyone — especially if you take hormonal medications or dopamine-related drugs. If you're on birth control, hormone replacement therapy, antipsychotics, or Parkinson's medications, check with your pharmacist first.

Start under professional guidance and watch for menstrual irregularities or other side effects.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agnus Castus Complex, straight from the product label.

Brand True Botanica
Net contents 55 mL; 1.86 Fluid Ounce(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336198
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agnus Castus Complex by True Botanica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
55
IngredientAmount% DV
Agnus Castus Herb Extract0.5 mL--
Vitex agnus-castus55 mg--

Other ingredients: Water, Distilled, Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested use: 20 drops (1 ml, 1/5 tsp) one to three times daily, or as suggested by your health care provider.

Formulation

Made with alcohol free, rhythmical proprietary processes. Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame, soy, wheat, or gluten.

Made with alcohol free, rhythmical proprietary processes.

Herbal Tincture

Precautions

Consult your health care provider before using this product if you are pregnant, lactating or have medical concerns or compatibility issues.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agnus Castus Complex by True Botanica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agnus Castus Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agnus Castus Complex by True Botanica

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container55 Amounts shown are per serving.

Agnus Castus Herb Extract

0.5 mL per serving

Other (inactive) ingredients: Water, Distilled, Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agnus Castus Complex by True Botanica Drug Interactions

Want to check YOUR meds against Agnus Castus Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Vitex agnus-castus 121

Individual Drug Interactions

The ingredients in Agnus Castus Complex interact with 121 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agnus Castus Complex interact with drugs. Each result below shows which ingredient is responsible. Vitex agnus-castus

Each ingredient & the kinds of drugs it affects

For each ingredient in Agnus Castus Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitex agnus-castus5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Vitex agnus-castus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agnus Castus Complex, from the product label.

True Botanica

See all True Botanica products
Name
True Botanica
Pharmacist Counseling Corner

Agnus Castus Complex by True Botanica: Common Questions

Does Agnus Castus Complex by True Botanica interact with any medications?
Yes. Based on its ingredients, Agnus Castus Complex has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agnus Castus Complex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Not without checking first. Vitex may interfere with oral contraceptives due to its hormone-modulating activity, which could reduce their effectiveness. Talk to your pharmacist or doctor before starting.
What are the most common side effects?
The most frequent ones are diarrhea, fatigue, headache, insomnia, irregular periods, nausea, stomach pain, and vomiting. Skin irritation and rashes have been reported too. Stop and contact your pharmacist if any are bothersome.
Is it safe during pregnancy or breastfeeding?
No. The safety data advises against both pregnancy and breastfeeding because vitex affects hormones and there isn't enough safety information in these situations. Talk to your doctor if you're planning to become pregnant or are nursing.
Does vitex actually work for PMS?
It's possibly effective for premenstrual syndrome and breast pain related to your cycle, based on the research we have. For other uses like anxiety or skin aging, there isn't enough reliable evidence yet.
How long does it take to see results?
The facts we have don't specify how long vitex takes to work. Your pharmacist can give you a better sense based on the research and what others have reported.
Can I use this long-term?
The safety data notes it's often well tolerated short-term, but because it affects hormones, it should be used under professional guidance. Talk with your pharmacist about how long it's appropriate for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agnus Castus Complex label
Go deeper

The Full Monographs Behind Agnus Castus Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

Agnus Castus Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitex Agnus-castus 23 references
  1. Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
  2. Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
  3. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
  4. Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
  5. Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
  6. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
  7. Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
  8. Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
  9. Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
  10. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
  11. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
  12. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
  13. Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
  14. Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
  15. Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
  16. Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
  17. Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
  18. Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
  19. Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
  20. Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
  21. Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
  22. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
  23. Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed

See these in context on the Vitex Agnus-castus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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