Aloe 450 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Aloe 450 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Aloe 450 is a dietary supplement by HoltraCeuticals with 1 active ingredient. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cape Aloe. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Aloe 450 by HoltraCeuticals
Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe 450 by HoltraCeuticals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Aloe 450 by HoltraCeuticals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Aloe 450 contains one active ingredient: Cape Aloe (aloe latex), a dried extract from the aloe plant. The capsules also contain two inactive ingredients — a vegetable capsule shell and magnesium stearate, a binder that helps hold the supplement together.
Does it work?
Moderate evidence
The evidence for aloe shows it's possibly effective for several conditions. Research suggests it may help with acne, obesity, diabetes, psoriasis, burns, and constipation.
The word 'possibly' means the data is promising but not yet definitive — so talk to us if you're considering this for a specific reason and want to know what the latest research shows.
How safe is it?
Well-documented data
Aloe gel is generally well tolerated when used in normal doses, but oral aloe latex — which is what's in this capsule — carries a higher risk of side effects, especially with long-term or high-dose use. You may experience abdominal pain, cramps, or diarrhea.
Serious effects like severe potassium loss, muscle weakness, and heart rhythm changes are rare but can happen, particularly with overuse. The data advises against taking aloe by mouth during pregnancy because it may stimulate the uterus and act as a strong laxative.
Avoid it while breastfeeding too, since safety data is limited and the laxative effects could affect your baby.
Meds to double-check
Major interaction found
Before starting Aloe 450, double-check if you take digoxin or other heart medications (most serious risk), blood thinners or antiplatelet drugs, diabetes medications, water pills, or other laxatives. If you're on warfarin, pay extra attention — aloe can increase its effects and bleeding risk.
Use the tool below to verify your medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Aloe might be worth considering if you're looking to address constipation, acne, or certain skin conditions — but it's not a product to take lightly. If you take a heart medication, blood thinner, diabetes drug, or water pill, check with us first.
And if you're pregnant or nursing, skip this one.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Aloe 450, straight from the product label.
| Brand | HoltraCeuticals |
|---|---|
| Barcode (UPC) | 615033618209 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2022 |
| DSLD ID | 271461 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Aloe 450 by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cape Aloe | 450 mg | -- |
Other ingredients: natural Vegetable Capsules, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: 1 capsule at bedtime (allow 24 hours before next dose) or as recommended by your health care professional.
Precautions
Notice: This product contains Cape Aloe. Read and follow directions carefully. Do not use this if you have or develop diarrhea, loose stools, or abdominal pain because cape aloe may worsen these conditions and be harmful to your health.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.
As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.
Keep out of reach of children.
Formulation
Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors.
Supports intestinal regularity
Vcaps
Storage
Keep container tightly closed. Store at room temperature.
General Statements
This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.
To re-order, visit: HoltraCeuticals.com
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Vcaps
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Aloe 450 by HoltraCeuticals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Aloe 450 by HoltraCeuticals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Cape Aloe
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Cape Aloe monograph & interactionsOther (inactive) ingredients: Natural Vegetable Capsules, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Aloe 450 by HoltraCeuticals Drug Interactions
HelloPharmacist Interaction Report
Aloe 450 by HoltraCeuticals contains Cape Aloe, which interacts with several medication types.
The most serious concern is digoxin (Lanoxin), a heart medication. Overuse of aloe latex can deplete potassium, which increases the risk of digoxin toxicity and serious side effects on the heart.
Read the full breakdown — every affected drug type, severity by severity
Aloe also poses Moderate-severity risks with blood thinners (anticoagulants) and antiplatelet drugs like warfarin (Coumadin) — it may increase bleeding risk. Similarly, it can lower blood sugar, raising the risk of low blood sugar (hypoglycemia) when combined with diabetes medications; you'll want to monitor your glucose closely.
Aloe latex can cause diarrhea, which amplifies warfarin's effects and bleeding risk. It may also compound potassium loss if you're on water pills (diuretics), and shouldn't be combined with other stimulant laxatives.
Finally, aloe may reduce the effectiveness of certain medications that your liver metabolizes (CYP1A2 substrates) — a Minor interaction. Altogether, these interactions span 460 individual medications.
Use the checker below to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Aloe 450?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Aloe 450 interact with 461 drugs. Click any drug to see the details.
1 of the 1 ingredient in Aloe 450 interact with drugs. Each result below shows which ingredient is responsible. Cape Aloe
Aspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Aspirin, Pentazocine interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Atenolol, Chlorthalidone interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Benzthiazide interactionBetrixabanBevyxxa
How Betrixaban interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Betrixaban interactionBisacodylDulcolax, Gentlax
How Bisacodyl interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Bisacodyl interactionBisacodyl, DocusateDulcolax Laxative Tabs
How Bisacodyl, Docusate interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Bisacodyl, Docusate interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bisoprolol, Hydrochlorothiazide interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
How Bivalirudin interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Bivalirudin interactionBromfenac SodiumBromsite, Prolensa
How Bromfenac Sodium interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Bromfenac Sodium interactionBumetanideBurinex
How Bumetanide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Bumetanide, Potassium interactionCabliviCablivi
How Cablivi interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Cablivi interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Cape Aloe + Caffeine, Potassium Salicylate, Salicylamide interactionCanagliflozinInvokana
How Canagliflozin interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe + Canagliflozin, Metformin Hydrochloride interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Candesartan Cilexetil, Hydrochlorothiazide interactionCangrelorKengreal
How Cangrelor interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe + Cangrelor interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe + Captopril, Hydrochlorothiazide interactionCasanthranolDoxidan Liquid Gels
How Casanthranol interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Casanthranol interactionCasanthranol, DocusateDoxidan
How Casanthranol, Docusate interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Casanthranol, Docusate interactionCasanthranol, Docusate PotassiumDialose Plus
How Casanthranol, Docusate Potassium interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Casanthranol, Docusate Potassium interactionCasanthranol, Docusate SodiumPeri-Colace
How Casanthranol, Docusate Sodium interacts with Aloe 450 — through 1 ingredient. Tap an ingredient for the detail:
Cape AloeStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe + Casanthranol, Docusate Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Aloe 450 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cape Aloe
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Aloe 450, from the product label.
HoltraCeuticals
See all HoltraCeuticals products- Name
- Holtorf Medical Group
- Street Address
- 2232 E. Maple Ave.
- City
- El Segundo
- State
- CA
- ZipCode
- 90245
- Web Address
- HoltraCeuticals.com
Aloe 450 by HoltraCeuticals: Common Questions
Does Aloe 450 by HoltraCeuticals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my constipation?
Can I take this if I'm pregnant?
What are the most common side effects I should expect?
Is this safe to use with my water pill?
Does this help with psoriasis or acne?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Aloe 450 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Aloe 450’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Aloe 450's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
- Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
- Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
- Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
- Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
- Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
- Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
- Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
- Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
- Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
- Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
- Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
- Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
- Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
- Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
- Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
- Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
- Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
- Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
- Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed
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