Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Anti-Glycation Support Ingredients & Drug Interactions

by Country Life Ageless Theory

Anti-Glycation Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Anti-Glycation Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Anti-Glycation Support is a dietary supplement by Country Life Ageless Theory with 4 active ingredients. Its ingredients are commonly taken for gluten-free thickener, source of carbohydrates and energy, pudding and dessert ingredient.Based on those ingredients, 602 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cinnulin PF, R-Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Anti-Glycation Support by Country Life Ageless Theory

Ask about any prescription or over-the-counter medication and we check it for interactions with Anti-Glycation Support by Country Life Ageless Theory — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Anti-Glycation Support by Country Life Ageless Theory

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Country Life Ageless Theory Anti-Glycation Support has 4 active ingredients. The blend includes R-lipoic acid (a form of alpha-lipoic acid), benfotiamine (a type of thiamine), Cinnulin PF (cassia cinnamon extract), and tapioca dextrin.

The capsule also contains inactive ingredients — hypromellose, cellulose, stearic acid, magnesium stearate, and silica — which are fillers, binders, and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support healthy blood sugar and reduce protein glycation.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Dyslipidemia, Hyperlipidemia, Hypertriglyceridemia, Metabolic syndrome — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Benfotiamine is rated "Possibly Effective" for Diabetic neuropathy.

The evidence for this product's active ingredients is mixed. R-lipoic acid is possibly effective for diabetic nerve damage and high cholesterol, and possibly effective for weight management.

Benfotiamine is possibly effective for diabetic nerve damage but was found possibly ineffective for kidney damage in diabetes. Cinnamon (Cinnulin PF) has insufficient evidence for most conditions it's marketed for — including diabetes itself, high cholesterol, and other uses.

Tapioca dextrin has insufficient evidence to rate for prediabetes. The product as a whole hasn't been studied as a combination.

The evidence, ingredient by ingredient Tapioca Cassia Cinnamon Alpha-lipoic Acid Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

R-lipoic acid is generally well tolerated but can lower blood sugar and works best under medical guidance. Common side effects include headache, heartburn, nausea, and vomiting.

Rare case reports have raised concerns about a type of autoimmune insulin syndrome. The safety data advises against R-lipoic acid in pregnancy and breastfeeding due to insufficient information.

Benfotiamine is generally well tolerated in studies, though long-term safety isn't fully known; a small number of trial participants reported allergic skin reactions and mild digestive discomfort. Pregnancy and breastfeeding safety hasn't been well studied for benfotiamine — talk with your doctor.

Cinnamon (Cinnulin PF) is generally safe in food amounts but may harm the liver at high supplement doses over time due to its coumarin content. Tapioca is considered safe in normal food amounts during pregnancy and breastfeeding.

Most side effects across these ingredients — when they occur — are digestive (bloating, flatulence, nausea) or skin-related (rash, irritation).

Side effects, ingredient by ingredient Tapioca Cassia Cinnamon Alpha-lipoic Acid Benfotiamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 603 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on blood thinners or antiplatelet drugs (R-lipoic acid may increase bleeding risk — Moderate). If you take diabetes medications, cassia cinnamon and R-lipoic acid may lower blood sugar further, potentially causing low blood sugar episodes — ask your doctor about dose adjustments.

If you're on chemotherapy, thyroid hormone, or drugs that stress the liver, talk with your pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with some evidence (R-lipoic acid for nerve damage and cholesterol) and others with limited proof of benefit (cinnamon, tapioca). It's worth considering if you have diabetic nerve damage and want to explore complementary options — but only under your doctor's eye, especially if you take blood thinners, diabetes meds, or thyroid hormone.

Check your exact medications with the tool on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Anti-Glycation Support, straight from the product label.

Brand Country Life Ageless Theory
Barcode (UPC) 015794053019
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333326
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Anti-Glycation Support by Country Life Ageless Theory, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
015794053019
IngredientAmount% DV
Tapioca Dextrin0 NP--
Blend500 mg--
R-Lipoic Acid75 mg--
Benfotiamine300 mg--
Cinnulin PF0 NP--

Other ingredients: Hypromellose, Cellulose, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Try all our Ageless Theory products: Telomere Support Active formula for cellular youthfulness Inspiring Greatness Please help us in our mission; recycle this box & bottle after use. Like/Follow us on our social platforms for new product news, recipes, giveaways and more! Tag us for a chance to be featured. @CountryLifeVitamins Facebook Instagram Try all our Ageless Theory products: Stem Cell Support Active formula to support cellular health

Country Life Ageless Theory offers a curated selection of dietary supplements representing the latest scientific advances in healthy aging. We believe that as you age, with the right lifestyle and nutritional choices, you can look and feel your absolute best at any stage of life. Each Ageless Theory product is formulated with the cleanest, most effective, natural ingredients. Support your overall wellness and vitality with Country Life's Ageless Theory Healthy Aging products. Scan the QR code to learn more about Ageless Theory

Yes recyclable packaging

Formulation

Healthy aging from within Support cell health & integrity Nourish provides nutrients important for healthy aging Renew support whole body health

Certified Gluten Free GFCO.org

Anti-Glycation Support provides important nutrients that maintain healthy blood sugar levels to assist in lessening the process of protein glycation. Did you know? AGEs (Advanced Glycation End Products) are a group of compounds that form when dietary sugars bind to proteins, lipids (fats), or nucleic acids (DNA or RNA) in the body. AGEs are known to accumulate in tissues over time. AGEs can increase free radical activity contributing to skin cell damage as well as other health concerns during the aging process. AGEs can accumulate in various tissues, reducing skin elasticity and overall health.

AGEs Process Glycation produces AGEs which damage the collagen network Healthy skin -> Glycation -> Aged skin due to glycation

Active formula to nourish damaged cells Supports healthy cellular aging Helps maintain healthy blood sugar levels in those individuals already in normal ranges Supports nerve health & function

Certified gluten-free

Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

Yes certified gluten-free by GFCO.org No yeast, corn or wheat No soy, milk or salt No sugar or preservatives No artificial colors, flavors or sweeteners

Yes certified vegan by the AVA

Yes manufacturing supports wind power

This product has been manufactured at a GMP registered facility

IGEN Non-GMO Tested This product does not contain common GE genes or proteins. Visit igenprogram.com

Seals/Symbols

Certified B Corporation Certified Gluten Free GFCO.org K (Kosher)

IGEN Non-GMO Tested

Formula

K (Kosher)

Clinically studied ingredients

Yes Kosher

Cinnulin PF

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take two (2) capsules daily with food.

Precautions

Do not exceed recommended dose.

As a reminder, discuss the supplements and medications that you take with your health care providers.

Do not accept if seal is broken.

Keep out of the reach of children.

Caution: Not for use by persons under the age of 18 or by pregnant or nursing women.

Caution: Not for use by persons under the age of 18 or by pregnant or nursing women. If you are taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur.

Storage

Store in a dry place between 59 degrees-86 degrees F.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Cinnulin PF is a registered trademark of IN Ingredients Inc.

Copyright 2024 Country Life

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Anti-Glycation Support by Country Life Ageless Theory label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Anti-Glycation Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Anti-Glycation Support by Country Life Ageless Theory

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blend

500 mg per serving

R-Lipoic Acid

Interacts with
263 drugs
75 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

R-Lipoic Acid monograph & interactions

Benfotiamine

No known
interactions
300 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Anti-Glycation Support by Country Life Ageless Theory Drug Interactions

Want to check YOUR meds against Anti-Glycation Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
602Drugs
602 Moderate

Ingredients driving the most interactions

Cinnulin PF 442
R-Lipoic Acid 263

Individual Drug Interactions

The ingredients in Anti-Glycation Support interact with 602 drugs. Click any drug to see the details.

2 of the 4 ingredients in Anti-Glycation Support interact with drugs. Each result below shows which ingredient is responsible. Cinnulin PF R-Lipoic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Anti-Glycation Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cinnulin PF2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnulin PF full monograph & interactions

R-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
R-Lipoic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Anti-Glycation Support, from the product label.

Country Life Ageless Theory

See all Country Life Ageless Theory products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Anti-Glycation Support by Country Life Ageless Theory: Common Questions

Does Anti-Glycation Support by Country Life Ageless Theory interact with any medications?
Yes. Based on its ingredients, Anti-Glycation Support has a known interaction with 602 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Anti-Glycation Support contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
R-lipoic acid is not recommended in pregnancy or breastfeeding — there isn't enough safety information. Benfotiamine and cinnamon safety during pregnancy and breastfeeding haven't been well studied, so caution is advised. Tapioca is considered safe in normal amounts during both. Talk with your doctor or pharmacist for personalized guidance.
What are the most common side effects?
The main side effects you might notice are digestive — bloating, flatulence, nausea, or vomiting — from the tapioca and other ingredients. Headache and heartburn can occur with R-lipoic acid. Skin reactions like rash are possible but uncommon. Most people tolerate these ingredients well.
Does this product actually help with blood sugar or diabetes?
R-lipoic acid is possibly effective for diabetic nerve damage, and cinnamon has been studied for diabetes, but the evidence for cinnamon itself is insufficient — we can't say it works for blood sugar. Tapioca has no established evidence for prediabetes. This product hasn't been tested as a whole formula.
Is there any risk if I'm already on blood thinner medication?
Yes. R-lipoic acid may have antiplatelet effects and could theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs. This is a Moderate concern, so check with your pharmacist before starting.
What does each ingredient do?
R-lipoic acid is an antioxidant studied for nerve damage and cholesterol. Benfotiamine is a form of vitamin B1 possibly effective for diabetic nerve damage. Cinnamon (Cinnulin PF) is included for blood-sugar support, though evidence is limited. Tapioca dextrin is a soluble fiber used as a filler.
How long is it safe to take this supplement?
Long-term safety isn't fully established for benfotiamine and cinnamon at supplement doses. Cinnamon at high doses over time may stress the liver due to its coumarin content. Talk with your doctor about how long you should take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Anti-Glycation Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Anti-Glycation Support label
Go deeper

The Full Monographs Behind Anti-Glycation Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tapioca

Tapioca is a starch made from the root of the cassava plant and is mainly used as a food ingredient and gluten-free thickener, not as a medicinal supplement. It is generally safe to eat in n...

Read the full Tapioca monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph →
Sources

Sources & How We Checked

Anti-Glycation Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 73 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tapioca 4 references
  1. Kehoe SH, Chopra H, Sahariah SA, et al. Effects of a food-based intervention on markers of micronutrient status among Indian women of low socio-economic status. Br J Nutr. 2015;113(5):813-21. PubMed
  2. Yamada Y, Hosoya S, Nishimura S, et al. Effect of bread containing resistant starch on postprandial blood glucose levels in humans. Biosci Biotechnol Biochem. 2005;69(3):559-66. PubMed
  3. Astina J, Sapwarobol S. Attenuation of glycaemic and insulin responses following tapioca resistant maltodextrin consumption in healthy subjects: a randomised cross-over controlled trial. J Nutr Sci 2020;9:e29. PubMed
  4. Astina J, Saphyakhajorn W, Borompichaichartkul C, Sapwarobol S. Tapioca resistant maltodextrin as a carbohydrate source of oral nutrition supplement (ONS) on metabolic indicators: a clinical trial. Nutrients 2022;14(5):916. PubMed

See these in context on the Tapioca monograph →

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
  22. Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):
  23. Cavalcanti D. R., da Silveira F. R. Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial. J Oral Pathol Med 2009;38(3):254-261. PubMed
  24. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med 2011;124( PubMed
  25. Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57.
  26. Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. PubMed
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See these in context on the Alpha-lipoic Acid monograph →

Benfotiamine 1 reference
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See these in context on the Benfotiamine monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
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  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
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  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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