Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Atrantil Ingredients & Drug Interactions

by Atrantil

Atrantil label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Atrantil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Atrantil is a dietary supplement by Atrantil with 3 active ingredients. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 861 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint leaf (Mentha haplocalyx) extract, Horse Chestnut extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Atrantil by Atrantil

Ask about any prescription or over-the-counter medication and we check it for interactions with Atrantil by Atrantil — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Atrantil by Atrantil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (550 mg) without saying how much of each component you get.

Atrantil contains three active ingredients in a proprietary blend: horse chestnut heartwood extract, quebracho heartwood extract, and peppermint leaf extract. Horse chestnut is used traditionally for vein health.

Peppermint has a track record in digestive comfort and nausea. Quebracho is included in the blend, though we hold limited data on it here.

The capsule itself is made from vegetable material, and the inactive ingredients are microcrystalline cellulose, magnesium stearate, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: relieve digestive issues and provide digestive support.
  • We looked for evidence on: Abdominal pain, Dyspepsia, Irritable bowel syndrome (IBS), Small intestinal bacterial overgrowth (SIBO), bloating, bowel regularity — and 1 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Peppermint is rated "Insufficient Reliable Evidence To Rate" for Abdominal pain, Small intestinal bacterial overgrowth (SIBO).

Peppermint leaf in Atrantil is likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion, nausea from chemotherapy, colon spasm during medical procedures, and side effects from endoscopy. Horse chestnut is possibly effective for chronic venous insufficiency (poor circulation in the legs) but hasn't shown reliable evidence for hemorrhoids, IBS, or kidney stones.

We don't have effectiveness data for quebracho in our system.

The evidence, ingredient by ingredient Horse Chestnut Peppermint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horse chestnut seed extract that's been properly processed is generally well tolerated, but raw plant parts are toxic. Common side effects from the extract include dizziness, stomach upset, headache, and itching.

Rare cases of serious heart problems and calf spasms have been reported. Horse chestnut is not safe in pregnancy or while breastfeeding.

Peppermint leaf is likely safe during pregnancy and breastfeeding in food amounts, though concentrated supplements should be avoided without approval from your provider. Orally, peppermint is generally well tolerated, with occasional reports of stomach pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting.

One case of severe allergic reaction (anaphylaxis) to peppermint candy has been reported, and in large amounts, it can cause chemical burns.

Side effects, ingredient by ingredient Horse Chestnut Peppermint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Peppermint, Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 862 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Atrantil, check your medications against these drug types: blood thinners and antiplatelet drugs (like warfarin, aspirin, clopidogrel); medications broken down by CYP3A4, CYP2C9, and CYP2C19 liver enzymes; and cyclosporine. These are the ones with documented Moderate interactions.

Use the medication checker on this page with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Atrantil may help with IBS and digestion thanks to peppermint, and horse chestnut for leg circulation, but it's not right for everyone. If you take blood thinners, antiplatelet drugs, cyclosporine, or medications metabolized by your liver's CYP enzymes, check with your pharmacist first.

Avoid it if you're pregnant or breastfeeding. Talk to your pharmacist about whether this product fits your medicines and health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Atrantil, straight from the product label.

Brand Atrantil
Barcode (UPC) 863594000142
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 202128
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Atrantil by Atrantil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
863594000142
IngredientAmount% DV
Proprietary Blend550 mg--
Quebracho (Quebracho colorado) Heartwood extract0 NP--
Horse Chestnut extract0 NP--
Peppermint leaf (Mentha haplocalyx) extract0 NP--

Other ingredients: Microcrystalline Cellulose, Vegetable capsule, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

A 1st First in class Atrantil is unlike any other product. It is a unique combination of polyphenol extracts that work together to relieve digestive issues and provide digestive support. Targeted treatment Atrantil targets the small bowel to provide relief where it is needed, where digestive issues begin. Intestinal support Atrantil reduces overall gut irritation and helps with gut motility. ORAC Powerful antioxidant combination Atrantil provides protection from cellular damage caused by oxidation. Everyday support Atrantil is ideal for every day, overall digestive support of both the small bowel and the colon. Gastroenterologist innovation Atrantil was developed by a board certified gastroenterologist for treatment of digestive issues.

Gastroenterologist developed Promotes overall digestive health

Relief From Occasional: Bloating Abdominal discomfort Change in bowel habits

90 capsules (275 mg) / 45 day supply

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Ahh-tran-teal What makes Atrantil unique? Atrantil was researched and created by a board certified gastroenterologist to provide overall digestive health and successfully help those suffering from bloating and abdominal discomfort. Providing safe and reliable bowel support is our priority, and as shown through studies, Atrantil can deliver daily relief. Atrantil is a one of a kind botanical blend of polyphenols to help those suffering from bloating and abdominal discomfort while protecting overall digestive health. Complete digestive defense- Targets problem bacteria at its source, in the small bowel, and provides support for the colon. Stay healthy- Over 80% of the immune system is in the gut. Gut microflora balance is essential to good health. Atrantil contains essential flavonoids and polyphenols, helping the body maintain its balance.

Made in the USA in a cGMP and UL certified facility, Atrantil provides confidence. Learn more at Atrantil.com 100% satisfaction guarantee

Seals/Symbols

NSF Certified for Sport

FDA Statement of Identity

Dietary supplement

Formula

Contains: Tree nut.

Precautions

Contains: Tree nut.

Caution: Not to be taken by pregnant or nursing mothers or by anyone with an allergy to any of this product’s ingredients.

Caution: Not to be taken by pregnant or nursing mothers or by anyone with an allergy to any of this product’s ingredients.

Keep out of reach of children.

If you take other medications, please consult with your doctor or qualified health care professional before using Atrantil.

Formulation

Free Of: Milk, eggs, peanuts, gluten, soy, and shellfish.

Have confidence Atrantil is gluten-free, non GMO and Vegan delivering only the purest ingredients and best in manufacturing.

Have confidence Atrantil is gluten-free, non GMO and Vegan delivering only the purest ingredients and best in manufacturing.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules per day up to 3x per day, with food.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Atrantil by Atrantil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Atrantil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Atrantil by Atrantil

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

550 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable capsule, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Atrantil by Atrantil Drug Interactions

Want to check YOUR meds against Atrantil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
861Drugs
799 Moderate 62 Minor

Ingredients driving the most interactions

Peppermint leaf (Mentha haplocalyx) extract 796
Horse Chestnut extract 122

Individual Drug Interactions

The ingredients in Atrantil interact with 861 drugs. Click any drug to see the details.

2 of the 3 ingredients in Atrantil interact with drugs. Each result below shows which ingredient is responsible. Peppermint leaf (Mentha haplocalyx) extract Horse Chestnut extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Atrantil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint leaf (Mentha haplocalyx) extract5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint leaf (Mentha haplocalyx) extract full monograph & interactions

Horse Chestnut extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Atrantil, from the product label.

Atrantil

See all Atrantil products
Name
KBS Research, Inc.
Street Address
15770 N. Dallas Parkway Suite 550
City
Dallas
State
TX
ZipCode
75248
Phone Number
214-984-3724
Web Address
www.Atrantil.com
Pharmacist Counseling Corner

Atrantil by Atrantil: Common Questions

Does Atrantil by Atrantil interact with any medications?
Yes. Based on its ingredients, Atrantil has a known interaction with 861 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Atrantil contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Atrantil safe to take while pregnant or breastfeeding?
Horse chestnut in Atrantil is not safe during pregnancy or breastfeeding. Peppermint is likely safe in food amounts during pregnancy and breastfeeding, but concentrated supplements should be avoided without your provider's approval. Talk to your doctor or pharmacist before using Atrantil if you're pregnant, planning to become pregnant, or breastfeeding.
What's horse chestnut actually used for?
Horse chestnut is possibly effective for chronic venous insufficiency — that's poor circulation and swelling in the legs. The evidence doesn't support it reliably for hemorrhoids, IBS, or kidney stones. Make sure you're taking a properly processed extract; raw horse chestnut parts are toxic.
Does peppermint really help with IBS?
Yes — peppermint leaf is likely effective for IBS. It's also possibly effective for indigestion, nausea from chemotherapy, colon spasm during medical procedures, and recovery problems after endoscopy. It's one of the better-studied ingredients in the blend.
What side effects might I get from Atrantil?
Peppermint can cause stomach pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting. Horse chestnut may cause dizziness, stomach upset, headache, and itching. Both ingredients are generally well tolerated, but these effects have been reported in some people.
What is quebracho in this supplement?
Quebracho is an ingredient in the proprietary blend, but we don't hold detailed data on it in our system. Your pharmacist can tell you more about its traditional uses and role in this product's formula.
Can I take Atrantil if I'm on a blood thinner?
That's a question for your pharmacist or doctor — horse chestnut may increase bleeding risk if you're on warfarin, aspirin, or other antiplatelet drugs, though this hasn't been proven in humans yet. It's important to check before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Atrantil label
Go deeper

The Full Monographs Behind Atrantil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph →
Sources

Sources & How We Checked

Atrantil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 62 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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