No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Be-Flexible Ingredients & Drug Interactions

by GNC WellBeing

Unknown Category: Botanical With Nutrients
No known interaction
The interaction bottom line No known interaction

Be-Flexible is a dietary supplement by GNC WellBeing with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Be-Flexible by GNC WellBeing

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Be-Flexible has three active ingredients. Hyaluronic Acid is a naturally occurring substance in the body that's often used for joint and skin health.

MSM and a Fast-Acting Proprietary Blend make up the rest of the formula, though the full makeup of that blend isn't detailed on the label. The product also contains inactive ingredients — cellulose, mica, titanium dioxide, mint flavor, vegetable acetoglycerides, sucralose, and chlorophyll — which are fillers and binders that give the supplement its form and taste.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hyaluronic Acid's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint flexibility and mobility support.
  • We looked for evidence on: Osteoarthritis, Exercise-induced muscle soreness, Joint stiffness, Cartilage support.
  • The closest evidence on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

Hyaluronic Acid in this product is possibly effective for dry eye and venous leg ulcers (slow-healing wounds in the legs caused by poor circulation). For aging skin, hay fever, and sexual dysfunction, the evidence we hold isn't strong enough to say whether it works or doesn't.

We don't have effectiveness data on file for MSM or the proprietary blend.

The evidence, ingredient by ingredient Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hyaluronic Acid is generally well tolerated when taken by mouth or applied to skin. The safety data on file comes with a note that long-term safety of supplements in general isn't fully studied.

Topically, it can occasionally cause eczema, redness, itching, bleeding, or infection at a wound site. Eye drops with hyaluronic acid have rarely caused eye pain.

The safety notes in our data advise caution with oral supplements unless your doctor recommends them — there isn't enough long-term safety information to be certain.

Side effects, ingredient by ingredient Hyaluronic Acid

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Since we haven't verified MSM or the proprietary blend, use the medication checker on this page to be certain before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This product may be worth considering if you're dealing with dry eyes or slow-healing leg wounds and want to explore natural options. Because we couldn't verify two of the three ingredients for drug interactions, check your medications here first.

If you take blood thinners, have a history of allergies, or are pregnant or breastfeeding, talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Be-Flexible, straight from the product label.

Brand GNC WellBeing
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 12334
Product type Botanical With Nutrients
Supplement form Unknown
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Be-Flexible by GNC WellBeing, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
IngredientAmount% DV
MSM250 mg--
Fast-Acting Proprietary Blend250 mg--
Hyaluronic Acid5 mg--

Other ingredients: Cellulose, Mica, Titanium Dioxide, natural Mint Flavor, Vegetable Acetoglycerides, Sucralose, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

be-FLEXIBLE(TM)

be-FLEXIBLE(TM) mobility & stretch formula: when you're working out, support for stiff joints is a must. This fast-acting mobility formula features a clinically-studied blend of herbs shown to support joint flexibility and mobility and promote the body's natural ability to maintain joint structure and function.

Not sure which vitamins to take? Think no more... We all want a life that's simple, complete and fulfilling. Now, GNC has a nutritional program that's just that. be-WHOLESOME(TM) conveniently provides you with the nutrients needed to keep you looking and feeling great. From complete multivitamin support to bone health, beauty nutrients and more, be-WHOLESOME(TM) has it.

Now with the help of be-WHOLESOME(TM), it's simple for you to achieve your daily nutritional goals. Carry your daily pak in your purse, gym bag or pocket!

be-WHOLE, be-BEAUTIFUL, be-FLEXIBLE, be-PROTECTED, be-BALANCED... be-WHOLESOME(TM)

General Statements

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

Compared to leading brand.

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

Formulation

No Artificial Colors, No Artificial Flavors, No Wheat, No Gluten.

Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

FDA Statement of Identity

dietary supplement for women

General

CODE 671411 BMG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take the contents of one pak daily with food.

See for yourself

Be-Flexible by GNC WellBeing label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Be-Flexible by GNC WellBeing

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formUnknown Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

MSM

250 mg per serving

Fast-Acting Proprietary Blend

250 mg per serving Form: Chinese Skullcap root extract, Cutch Tree wood & bark extract

Hyaluronic Acid

No known
interactions
5 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Other (inactive) ingredients: Cellulose, Mica, Titanium Dioxide, Natural Mint Flavor, Vegetable Acetoglycerides, Sucralose, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Be-Flexible by GNC WellBeing Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Be-Flexible. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Be-Flexible, from the product label.

GNC WellBeing

See all GNC WellBeing products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Be-Flexible by GNC WellBeing: Common Questions

Does Be-Flexible by GNC WellBeing interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Be-Flexible. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Be-Flexible contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hyaluronic acid and what is it used for in this supplement?
Hyaluronic acid is a substance your body makes naturally. In supplements, it's used for joint support and skin hydration. The research we hold shows it's possibly effective for dry eye and slow-healing leg wounds, though evidence for anti-aging skin effects isn't established.
What are the side effects of hyaluronic acid?
When taken by mouth or put on your skin, hyaluronic acid is generally well tolerated. Topical application has rarely caused eczema, redness, itching, bleeding, or infection at a wound. Eye drops containing it have very rarely caused eye pain.
Is this product safe to take long-term?
Hyaluronic Acid appears well tolerated for most adults, but long-term safety of supplements in general isn't fully studied. The safety notes on file advise caution with oral supplements — talk with your doctor before taking it long-term unless they've recommended it.
Can I take this product while pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for the ingredients in this product. Talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Be-Flexible is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Be-Flexible label
Go deeper

The Full Monographs Behind Be-Flexible’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Be-Flexible's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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