Benfotiamine 300 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Benfotiamine 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Benfotiamine 300 mg is a dietary supplement by Doctor's Best with 2 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), supporting healthy nerve function, thiamine deficiency.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Benfotiamine 300 mg by Doctor's Best
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains two active ingredients: benfotiamine (a fat-soluble form of vitamin B1) and L-leucine (an amino acid). Benfotiamine is designed to be absorbed more easily than standard thiamine.
The capsule also contains microcrystalline cellulose, modified cellulose, and silicon dioxide as inactive ingredients to hold everything together.
Does it work?
Moderate evidence
Benfotiamine is possibly effective for diabetic neuropathy (nerve damage from diabetes), though the evidence is limited. For diabetic nephropathy (kidney damage from diabetes), the evidence suggests it's probably not effective.
The data we hold doesn't establish effectiveness for alcohol use disorder, Alzheimer disease, or general peripheral nerve damage — there simply isn't enough reliable evidence yet.
How safe is it?
Well-documented data
Benfotiamine is generally well tolerated in short-term studies, though long-term safety hasn't been fully worked out. In one six-week trial of 98 patients taking 300–600 mg daily, a small number reported allergic skin reactions (two participants) and mild stomach discomfort (six participants), at rates no higher than placebo.
There isn't enough safety information to know how it affects pregnancy or breastfeeding, so talk with your doctor or pharmacist before using it if you're pregnant, planning pregnancy, or nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for the benfotiamine component of this product. We couldn't check L-leucine, so if you want to be thorough, mention this product to your doctor or pharmacist when reviewing your medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Benfotiamine is an option if you're looking for support with diabetic nerve pain and your doctor thinks it's worth trying. Because long-term safety data is limited and pregnancy/breastfeeding safety isn't well studied, it's worth a conversation with your doctor or pharmacist first to see if it fits your situation.
No documented medication interactions are on file for the benfotiamine in this product, but always confirm with your own healthcare provider before starting any new supplement.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Benfotiamine 300 mg, straight from the product label.
| Brand | Doctor's Best |
|---|---|
| Barcode (UPC) | 753950002708 |
| Net contents | 60 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 269585 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Benfotiamine 300 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Leucine | 40 mg | -- |
| Benfotiamine | 300 mg | -- |
Other ingredients: Microcrystalline Cellulose, Modified Cellulose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Benfotiamine (S-benzoylthiamine-O-monophosphate) is a derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin. Benfotiamine raises the blood level of thiamin pyrophosphate (TPP), the biologically active co-enzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.
With BenfoPure
Formulation
Helps maintain healthy cells in the presence of blood glucose Helps control formation of Advanced Glycation End products (AGEs) Helps normalize cellular processes fueled by glucose metabolites
Helps maintain healthy glucose metabolism
Vegan
Non-GMO Gluten free Soy free
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
The BenfoPure logo design is a trademark of Hamari Chemicals Ltd., Japan.
Science-Based Nutrition
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Adult Use: Take 1 capsule daily, with or without food, or as recommended by a nutritionally-informed physician.
Storage
Store in a cool dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Benfotiamine 300 mg by Doctor's Best label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Benfotiamine 300 mg by Doctor's Best
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Leucine
Benfotiamine
No knowninteractions
Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...
Benfotiamine monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Modified Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Benfotiamine 300 mg by Doctor's Best Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Benfotiamine 300 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Benfotiamine 300 mg, from the product label.
Doctor's Best
See all Doctor's Best products- Name
- Doctor's Best, Inc.
- State
- California
- Phone Number
- (800) 777-2474
- Web Address
- www.drbvitamins.com
Benfotiamine 300 mg by Doctor's Best: Common Questions
Does Benfotiamine 300 mg by Doctor's Best interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is benfotiamine and how is it different from regular vitamin B1?
Will this help with my diabetic nerve pain?
What side effects should I watch for?
Can I take this if I'm pregnant or breastfeeding?
Does this have a lot of fillers in it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Benfotiamine 300 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Benfotiamine 300 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Benfotiamine 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 1 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Benfotiamine 1 reference
- Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC