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Dietary supplement

Digestive Probiotic 20 Billion Ingredients & Drug Interactions

by Doctor's Best

Digestive Probiotic 20 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Probiotic 20 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Probiotic 20 Billion is a dietary supplement by Doctor's Best with 6 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus strain La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Probiotic 20 Billion by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Probiotic 20 Billion by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Probiotic 20 Billion by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (95 mg) without saying how much of each component you get.

This product contains 6 ingredients, including a proprietary probiotic blend made up of three Bifidobacterium lactis strains (HN019, Bl-04, and Bl-07), plus three Lactobacillus strains: acidophilus (La-14), salivarius (Ls-33), and paracasei (Lpc-37). Together they deliver 20 billion colony-forming units of live beneficial bacteria designed to support digestive health.

The remaining ingredients are inactive — microcrystalline cellulose, hypromellose, calcium laurate, and silicon dioxide — which help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and intestinal health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Inflammatory bowel disease (IBD), Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

Lactobacillus acidophilus La-14, one of the strains in this blend, is rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence isn't strong enough to be definitive, but the data suggests it may help.

For acute respiratory distress syndrome (ARDS), there's insufficient reliable evidence to say whether it works. We don't hold effectiveness ratings for the other four probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Some people taking probiotics (especially combined with other probiotic strains) experience mild gastrointestinal side effects like stomach discomfort, abdominal pain, gas, bloating, or diarrhea — but these are uncommon.

In rare cases, live probiotic bacteria can cause serious infections (bacteremia, sepsis, or other invasive infections), mostly in people whose immune systems are already compromised or who have other underlying conditions; most cases involve bacteria that translocate (move) from elsewhere in the body. Since data are limited, talk with your doctor before starting this product, especially if you have a weakened immune system or serious illness.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to watch: taking them at the same time as this probiotic may make the probiotic less effective. Ask your doctor or pharmacist to help you space out the doses if you're on an antibiotic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, and a few other digestive or infection-related conditions, though the evidence is suggestive rather than definitive. The main caution is timing it away from antibiotics — they can wipe out the live bacteria in the product.

If you take any medications or have a weakened immune system, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Probiotic 20 Billion, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950003620
Net contents 30 Veggie Cap(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269621
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Probiotic 20 Billion by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
753950003620
IngredientAmount% DV
Proprietary Probiotic Blend95 mg--
Bifidobacterium lactis strain HN0190 NP--
Bifidobacterium lactis strain Bl-040 NP--
Bifidobacterium lactis strain Bl-070 NP--
Lactobacillus acidophilus strain La-140 NP--
Lactobacillus salivarius strain Ls-330 NP--
Lactobacillus paracasei strain Lpc-370 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Calcium Laurate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestive Probiotic with HOWARU probiotics: Helps support balanced intestinal flora Helps support digestion and bowel regularity Helps support overall intestinal health

Doctor's Best Digestive Probiotic supplies three strains of Bifidobacterium and three strains of Lactobacillus probiotics, all of which are proven benefits for digestive and whole-body health. Scientific studies have shown that ingestion of these specific strains of friendly bacteria supports several physiological functions, particularly the body's natural immune system and general intestinal well-being. The probiotic strains found in Doctor's Best Digestive Probiotic at the potency of 20 Billion Colony Forming Units (CFU) help support gastrointestinal tract function and digestive health.

Brand IP Statement(s)

Science-Based Nutrition Doctor's Best

HOWARU is a trademark of DuPont used under license by Doctor’s Best, Inc.

Formulation

Helps support digestive and intestinal health

Promotes healthy intestinal function

Vegan

Non-GMO Gluten free

Bifodobacteria and Lactobacilli are important components of the intestinal microflora. The intestinal tract naturally contains a beneficial ecosystem of good bacteria that contributes to the body's healthy immune response. Lifestyle changes such as occasional stress, diet or environment commonly result in the loss of beneficial bacteria which may cause digestive imbalance in the intestinal flora. A balanced intestinal microflora is vital in keeping the body in healthy working order.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule daily with food, or as recommended by a nutritionally informed physician.

Precautions

Warning: Consult your physician before using Probiotics if you are pregnant, nursing or have a medical condition.

Storage

Store in a cool dry place. No refrigeration necessary in blister pack.

General Statements

1 CFU = 1 Colony Forming Unit

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Probiotic 20 Billion by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Probiotic 20 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Probiotic 20 Billion by Doctor's Best

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

95 mg per serving
  • › Bifidobacterium lactis strain HN019
  • › Bifidobacterium lactis strain Bl-04
  • › Bifidobacterium lactis strain Bl-07
  • › Lactobacillus acidophilus strain La-14
  • › Lactobacillus salivarius strain Ls-33
  • › Lactobacillus paracasei strain Lpc-37

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Calcium Laurate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Probiotic 20 Billion by Doctor's Best Drug Interactions

Want to check YOUR meds against Digestive Probiotic 20 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus strain La-14 182

Individual Drug Interactions

The ingredients in Digestive Probiotic 20 Billion interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Digestive Probiotic 20 Billion interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus strain La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Probiotic 20 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus strain La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus strain La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Probiotic 20 Billion, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
State
California
ZipCode
92612
Phone Number
(800) 777-2474
Web Address
drbvitamins.com
Pharmacist Counseling Corner

Digestive Probiotic 20 Billion by Doctor's Best: Common Questions

Does Digestive Probiotic 20 Billion by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Digestive Probiotic 20 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Probiotic 20 Billion contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Should I take this at the same time as my antibiotic?
No — antibiotics can kill off the live beneficial bacteria in this probiotic, making it less effective. Talk with your doctor or pharmacist about how far apart to take them. Spacing them a few hours apart is often recommended, but your specific antibiotic and situation may be different.
Can this probiotic cause side effects?
Most people tolerate it well, but some may experience mild gastrointestinal effects like stomach discomfort, gas, bloating, or diarrhea — these are uncommon. In very rare cases, especially in people with weakened immune systems, probiotic bacteria can cause serious infections, though this is not typical.
Is this safe during pregnancy?
Lactobacillus acidophilus, the strain we have safety data for, is rated possibly safe in pregnancy. We don't hold pregnancy safety information for the other four strains in this blend. Talk with your doctor or midwife before taking it during pregnancy to make sure it's right for you.
What does 20 billion mean?
That's the total number of live colony-forming units (CFUs) — basically, individual beneficial bacteria — in the product. It's a measure of how many living organisms you're getting per dose.
Does this product contain any fillers?
Yes — the inactive ingredients are microcrystalline cellulose, hypromellose, calcium laurate, and silicon dioxide. These help form and stabilize the capsule and are standard in most supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Probiotic 20 Billion label
Go deeper

The Full Monographs Behind Digestive Probiotic 20 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Digestive Probiotic 20 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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