Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Adaptive Stress CBD Soft Gels 7.5 mg Ingredients & Drug Interactions

by Bluebird Botanicals

Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Adaptive Stress CBD Soft Gels 7.5 mg is a dietary supplement by Bluebird Botanicals with 6 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 1,484 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Rhodiola Root Extract, Powder, Full-Spectrum Hemp, Distillate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (39.68 mg) without saying how much of each component you get.

This product contains 6 ingredients, including a proprietary blend. The active components are Sensoril (a standardized ashwagandha extract), rhodiola root extract, full-spectrum hemp distillate, broad-spectrum hemp distillate, and cannabigerol isolate.

These are suspended in fractionated coconut oil. The remaining ingredients—gelatin, glycerin, water, turmeric extract, beeswax, and sunflower lecithin—are inactive excipients that form the softgel capsule and help deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: stress management and adaptive resilience.
  • We looked for evidence on: Stress, Anxiety, Generalized anxiety disorder (GAD), Depression, Fatigue, Insomnia — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Chronic fatigue syndrome (CFS), Depression.

Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD), based on available evidence. For bipolar disorder, the evidence is insufficient to rate it.

Rhodiola's effectiveness for conditions like GAD, altitude sickness, and athletic performance has insufficient reliable evidence. The hemp ingredients and coconut oil lack established evidence for the conditions listed in our data, and cannabigerol isolate's effectiveness is not rated in our records.

The evidence, ingredient by ingredient Coconut Hemp Ashwagandha Rhodiola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects are diarrhea, nausea, vomiting, and gastrointestinal upset, though these don't typically occur at standard doses.

Rare serious concerns include liver damage (acute hepatitis and liver failure), and isolated reports of intracranial bleeding. Ashwagandha is traditionally thought to risk miscarriage, so avoid it during pregnancy, and there isn't enough safety data for breastfeeding.

Rhodiola is generally well tolerated for short-term use; dizziness and changes in saliva production are the most common effects. Long-term safety isn't well studied, and it should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Coconut oil is generally safe in normal food amounts, but concentrated supplement doses aren't well studied. Allergic reactions (from hives to anaphylaxis) are possible in people with coconut sensitivity.

Hemp products are generally well tolerated in food amounts, though concentrated extracts are less studied. Rare serious effects include anaphylaxis and cardiac issues; one case report noted liver enzyme elevation in a young child given high-dose hemp extract.

Pregnancy and lactation safety data for hemp are not on file.

Side effects, ingredient by ingredient Coconut Hemp Ashwagandha Rhodiola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Rhodiola, Ashwagandha, Coconut, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,485 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use blood pressure medications (antihypertensive drugs), antidiabetes drugs, benzodiazepines, sedatives or other CNS depressants, thyroid hormones, immunosuppressant medications, blood thinners (anticoagulants or antiplatelet drugs), ACE inhibitors, or any drug metabolized by your liver enzymes—especially if you take losartan (Cozaar). Also flag any drugs known to stress the liver or estrogen-based hormone therapies.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support sleep, stress, or mild anxiety, ashwagandha and rhodiola together have some evidence behind them. But this product isn't for you if you take blood pressure meds, diabetes drugs, benzodiazepines, thyroid hormones, immunosuppressants, or blood thinners without checking with your pharmacist first.

Pregnant or breastfeeding? Talk to your doctor before starting.

Run your medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adaptive Stress CBD Soft Gels 7.5 mg, straight from the product label.

Brand Bluebird Botanicals
Barcode (UPC) 856888009396
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307838
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Soft Gel(s)
Maximum serving Sizes:
1 Soft Gel(s)
Servings per container
30
UPC/BARCODE
856888009396
IngredientAmount% DV
Proprietary Blend39.68 mg--
Sensoril125 mg--
Rhodiola Root Extract, Powder100 mg--
Coconut Oil, Fractionated0 NP--
Full-Spectrum Hemp, Distillate0 NP--
Cannabigerol Isolate0 NP--
Broad-Spectrum Hemp, Distillate0 NP--

Other ingredients: Gelatin, Glycerin, Water, Purified, Turmeric Extract, Yellow Beeswax, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ashwagandha + rhodiola CBD: 7.5 mg per serving CBG: 7.5 mg per serving CBD: 225 mg per bottle CBG: 225 mg per bottle

Non-synthetic cannabinoids derived from USA-grown hemp.

Total THC less than or equal to 31.8 mg per container Total THC less than or equal to 1.06 mg per serving

FDA Statement of Identity

Hemp Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA has not evaluated or approved this product for safety or efficacy.

Storage

Store in a cool, dark place.

Precautions

Keep out of reach of children.

Do not exceed 2 soft gels (2 servings) per day.

Warning: Do not use if pregnant, nursing or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.

Warning: Do not use if pregnant, nursing or under 18 years of age.

This product contains hemp with <= 0.3% delta-9-THC on a dry-weight basis. Consumption could result in a failed drug test.

Warning: Consuming this product can expose you to chemicals including delta-9-THC, which is known to the state of California to cause birth defects or other reproductive harm. See: www.P65Warnings.ca.gov/food.

Suggested/Recommended/Usage/Directions

Suggested use: Take one soft gel by mouth, twice daily, or as directed by a medical professional.

Take 1 soft gel before early afternoon with 4-8 oz of water

General Statements

Scan for details.

Seals/Symbols

US Hemp Authority Certified

See for yourself

Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Soft Gel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

39.68 mg per serving

Sensoril

Interacts with
1,372 drugs
125 mg per serving Form: Ashwagandha Leaf, Root Extract, Powder

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions

Rhodiola Root Extract, Powder

Interacts with
1,271 drugs
100 mg per serving Form: Rhodiola rosea Root Extract, Powder

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola Root Extract, Powder monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Turmeric Extract, Yellow Beeswax, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals Drug Interactions

Want to check YOUR meds against Adaptive Stress CBD Soft Gels 7.5 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,484Drugs
1,085 Moderate 399 Minor

Ingredients driving the most interactions

Sensoril 1,372

Each ingredient & the kinds of drugs it affects

For each ingredient in Adaptive Stress CBD Soft Gels 7.5 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C

Rhodiola Root Extract, Powder10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B

Full-Spectrum Hemp, Distillate6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D

Coconut Oil, Fractionated1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Adaptive Stress CBD Soft Gels 7.5 mg, from the product label.

Bluebird Botanicals

See all Bluebird Botanicals products
Name
Bluebird Botanicals
City
Louisville
State
CO
ZipCode
80027
Phone Number
(720) 726-5132
Web Address
BluebirdBotanicals.com
Pharmacist Counseling Corner

Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals: Common Questions

Does Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals interact with any medications?
Yes. Based on its ingredients, Adaptive Stress CBD Soft Gels 7.5 mg has a known interaction with 1,484 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adaptive Stress CBD Soft Gels 7.5 mg contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me sleep?
Ashwagandha in this product is rated possibly effective for insomnia based on available evidence. It's not a guarantee, and results vary from person to person.
Can I take this while pregnant?
No. Ashwagandha is traditionally thought to risk miscarriage and is rated likely unsafe during pregnancy. You should avoid this product if you're pregnant or trying to conceive, and talk with your doctor about safer alternatives.
Is it safe to take if I'm breastfeeding?
The ashwagandha and rhodiola in this product don't have enough safety data for breastfeeding. It's best to avoid it while nursing and check with your pharmacist or doctor about what's safe for you and your baby.
What's the proprietary blend, and why is it proprietary?
The product lists a proprietary blend, which means the exact amounts of its ingredients aren't disclosed on the label—that's the manufacturer's choice. We've evaluated each ingredient separately instead.
Could this cause diarrhea or stomach upset?
Yes. Ashwagandha can cause diarrhea, nausea, vomiting, and gastrointestinal upset, though these side effects don't commonly happen at typical doses. Rhodiola can cause dizziness and changes in saliva production.
What about the hemp and CBD in this product?
This product contains full-spectrum and broad-spectrum hemp distillates and cannabigerol isolate. Hemp ingredients have no established evidence for the conditions in our data, and concentrated hemp extracts aren't as well studied as whole hemp food. We hold no interaction data for cannabigerol isolate.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adaptive Stress CBD Soft Gels 7.5 mg label
Sources

Sources & How We Checked

Adaptive Stress CBD Soft Gels 7.5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
  21. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
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Hemp 12 references
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See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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