Adaptive Stress CBD Soft Gels 7.5 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Adaptive Stress CBD Soft Gels 7.5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Adaptive Stress CBD Soft Gels 7.5 mg is a dietary supplement by Bluebird Botanicals with 6 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 1,484 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Rhodiola Root Extract, Powder, Full-Spectrum Hemp, Distillate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals
Ask about any prescription or over-the-counter medication and we check it for interactions with Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 6 ingredients, including a proprietary blend. The active components are Sensoril (a standardized ashwagandha extract), rhodiola root extract, full-spectrum hemp distillate, broad-spectrum hemp distillate, and cannabigerol isolate.
These are suspended in fractionated coconut oil. The remaining ingredients—gelatin, glycerin, water, turmeric extract, beeswax, and sunflower lecithin—are inactive excipients that form the softgel capsule and help deliver the actives.
Does it work?
Moderate evidence
Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD), based on available evidence. For bipolar disorder, the evidence is insufficient to rate it.
Rhodiola's effectiveness for conditions like GAD, altitude sickness, and athletic performance has insufficient reliable evidence. The hemp ingredients and coconut oil lack established evidence for the conditions listed in our data, and cannabigerol isolate's effectiveness is not rated in our records.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects are diarrhea, nausea, vomiting, and gastrointestinal upset, though these don't typically occur at standard doses.
Rare serious concerns include liver damage (acute hepatitis and liver failure), and isolated reports of intracranial bleeding. Ashwagandha is traditionally thought to risk miscarriage, so avoid it during pregnancy, and there isn't enough safety data for breastfeeding.
Rhodiola is generally well tolerated for short-term use; dizziness and changes in saliva production are the most common effects. Long-term safety isn't well studied, and it should be avoided during pregnancy and breastfeeding due to insufficient safety data.
Coconut oil is generally safe in normal food amounts, but concentrated supplement doses aren't well studied. Allergic reactions (from hives to anaphylaxis) are possible in people with coconut sensitivity.
Hemp products are generally well tolerated in food amounts, though concentrated extracts are less studied. Rare serious effects include anaphylaxis and cardiac issues; one case report noted liver enzyme elevation in a young child given high-dose hemp extract.
Pregnancy and lactation safety data for hemp are not on file.
Meds to double-check
Moderate interaction found
Check before taking this product if you use blood pressure medications (antihypertensive drugs), antidiabetes drugs, benzodiazepines, sedatives or other CNS depressants, thyroid hormones, immunosuppressant medications, blood thinners (anticoagulants or antiplatelet drugs), ACE inhibitors, or any drug metabolized by your liver enzymes—especially if you take losartan (Cozaar). Also flag any drugs known to stress the liver or estrogen-based hormone therapies.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're looking to support sleep, stress, or mild anxiety, ashwagandha and rhodiola together have some evidence behind them. But this product isn't for you if you take blood pressure meds, diabetes drugs, benzodiazepines, thyroid hormones, immunosuppressants, or blood thinners without checking with your pharmacist first.
Pregnant or breastfeeding? Talk to your doctor before starting.
Run your medications through the checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Adaptive Stress CBD Soft Gels 7.5 mg, straight from the product label.
| Brand | Bluebird Botanicals |
|---|---|
| Barcode (UPC) | 856888009396 |
| Net contents | 30 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 307838 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 39.68 mg | -- |
| Sensoril | 125 mg | -- |
| Rhodiola Root Extract, Powder | 100 mg | -- |
| Coconut Oil, Fractionated | 0 NP | -- |
| Full-Spectrum Hemp, Distillate | 0 NP | -- |
| Cannabigerol Isolate | 0 NP | -- |
| Broad-Spectrum Hemp, Distillate | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, Water, Purified, Turmeric Extract, Yellow Beeswax, Sunflower Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Ashwagandha + rhodiola CBD: 7.5 mg per serving CBG: 7.5 mg per serving CBD: 225 mg per bottle CBG: 225 mg per bottle
Non-synthetic cannabinoids derived from USA-grown hemp.
Total THC less than or equal to 31.8 mg per container Total THC less than or equal to 1.06 mg per serving
FDA Statement of Identity
Hemp Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA has not evaluated or approved this product for safety or efficacy.
Storage
Store in a cool, dark place.
Precautions
Keep out of reach of children.
Do not exceed 2 soft gels (2 servings) per day.
Warning: Do not use if pregnant, nursing or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.
Warning: Do not use if pregnant, nursing or under 18 years of age.
This product contains hemp with <= 0.3% delta-9-THC on a dry-weight basis. Consumption could result in a failed drug test.
Warning: Consuming this product can expose you to chemicals including delta-9-THC, which is known to the state of California to cause birth defects or other reproductive harm. See: www.P65Warnings.ca.gov/food.
Suggested/Recommended/Usage/Directions
Suggested use: Take one soft gel by mouth, twice daily, or as directed by a medical professional.
Take 1 soft gel before early afternoon with 4-8 oz of water
General Statements
Scan for details.
Seals/Symbols
US Hemp Authority Certified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Soft Gel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Coconut Oil, Fractionated
- › Full-Spectrum Hemp, Distillate
- › Cannabigerol Isolate
- › Broad-Spectrum Hemp, Distillate
Sensoril
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Sensoril monograph & interactionsRhodiola Root Extract, Powder
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola Root Extract, Powder monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Turmeric Extract, Yellow Beeswax, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.
Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals Drug Interactions
HelloPharmacist Interaction Report
Adaptive Stress CBD Soft Gels by Bluebird Botanicals contains multiple ingredients with documented interactions.
The most serious concern is ashwagandha (Sensoril), which theoretically may increase the risk of liver damage if taken alongside hepatotoxic drugs—medications known to stress the liver. Ashwagandha also carries Moderate-severity interactions with CNS depressants (sedatives, sleeping pills, anxiety medications), antihypertensive drugs (blood pressure medications), benzodiazepines (like Valium or Klonopin), antidiabetes drugs, thyroid hormones, and immunosuppressants.
A Minor interaction exists with drugs metabolized by the liver enzyme CYP1A2.
Read the full breakdown — every affected drug type, severity by severity
Rhodiola root extract adds Moderate interactions with antihypertensive drugs, antidiabetes drugs, and several enzyme-metabolized drugs (CYP2C9 and P-glycoprotein substrates), as well as a specific interaction with losartan (Cozaar), a common blood pressure medication. It also carries Minor interactions with CYP1A2 and CYP3A4 substrates.
Coconut oil has a Minor interaction with antidiabetes drugs. The hemp ingredients (full-spectrum and broad-spectrum distillate) bring Moderate interactions with estrogens (hormone therapy) and Minor interactions with antihypertensive drugs, blood thinners (anticoagulants and antiplatelet agents), ACE inhibitors, and CYP1A2 and CYP3A4 substrates.
We could not check cannabigerol isolate—we hold no interaction data for it. Altogether, these interactions span 1,462 individual medications.
Before you start this product, use the medication checker below to search your exact drugs, especially if you take blood pressure medications, diabetes medications, blood thinners, sedatives, or thyroid hormones.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Adaptive Stress CBD Soft Gels 7.5 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Adaptive Stress CBD Soft Gels 7.5 mg interact with 1,484 drugs. Click any drug to see the details.
4 of the 6 ingredients in Adaptive Stress CBD Soft Gels 7.5 mg interact with drugs. Each result below shows which ingredient is responsible. Sensoril Rhodiola Root Extract, Powder Full-Spectrum Hemp, Distillate Coconut Oil, Fractionated
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 2 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + 6-mercaptopurine interactionRhodiola Root Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Root Extract, Powder + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 1 ingredient. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 1 ingredient. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Abacavir, Lamivudine interactionAbiraterone
How Abiraterone interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Abiraterone interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Abiraterone interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Abiraterone Acetate interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Abiraterone Acetate interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Sensoril + Abrocitinib interactionRhodiola Root Extract, PowderImmunosuppressants, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Root Extract, Powder + Abrocitinib interactionBroad-spectrum Hemp, DistillateAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Broad-spectrum Hemp, Distillate + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
Rhodiola Root Extract, PowderP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract, Powder + Acalabrutinib interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acalabrutinib interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Sensoril + Acarbose interactionRhodiola Root Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola Root Extract, Powder + Acarbose interactionCoconut Oil, FractionatedAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut Oil, Fractionated + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
Rhodiola Root Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract, Powder + Acebutolol interactionSensorilHepatotoxic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Acebutolol interactionBroad-spectrum Hemp, DistillateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
Read the full Broad-spectrum Hemp, Distillate + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 2 ingredients. Tap an ingredient for the detail:
SensorilCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril + Acepromazine interactionRhodiola Root Extract, PowderCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract, Powder + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Aspirin interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Aspirin interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Aspirin, Caffeine interactionBroad-spectrum Hemp, DistillateAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Aspirin, Caffeine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Acetaminophen, Butalbital interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Butalbital interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Acetaminophen, Butalbital, Caffeine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Butalbital, Caffeine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Butalbital, Caffeine, Codeine interactionRhodiola Root Extract, PowderCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Butalbital, Codeine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Butalbital, Codeine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCns Depressants, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril + Acetaminophen, Butalbital, Codeine Phosphate interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Butalbital, Codeine Phosphate interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionRhodiola Root Extract, PowderCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Acetaminophen, Caffeine, Codeine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Codeine interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Acetaminophen, Caffeine, Dihydrocodeine interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Dihydrocodeine interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Caffeine, Isometheptene interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Isometheptene interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Acetaminophen, Caffeine, Pyrilamine interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Caffeine, Pyrilamine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +3 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRhodiola Root Extract, PowderCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Sensoril + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionBroad-spectrum Hemp, DistillateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionRhodiola Root Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Adaptive Stress CBD Soft Gels 7.5 mg — through 3 ingredients. Tap an ingredient for the detail:
SensorilCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionRhodiola Root Extract, PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionBroad-spectrum Hemp, DistillateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad-spectrum Hemp, Distillate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Adaptive Stress CBD Soft Gels 7.5 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Sensoril
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Rhodiola Root Extract, Powder
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Full-Spectrum Hemp, Distillate
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Coconut Oil, Fractionated
Antidiabetes Drugs
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.
Brand information
Manufacturer and brand details for Adaptive Stress CBD Soft Gels 7.5 mg, from the product label.
Bluebird Botanicals
See all Bluebird Botanicals products- Name
- Bluebird Botanicals
- City
- Louisville
- State
- CO
- ZipCode
- 80027
- Phone Number
- (720) 726-5132
- Web Address
- BluebirdBotanicals.com
Adaptive Stress CBD Soft Gels 7.5 mg by Bluebird Botanicals: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Adaptive Stress CBD Soft Gels 7.5 mg is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Adaptive Stress CBD Soft Gels 7.5 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Coconut
Interacts with 86 drugsCoconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...
Read the full Coconut monograph → Herb & supplement monographHemp
Interacts with 938 drugsHemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...
Read the full Hemp monograph → Herb & supplement monographAshwagandha
Interacts with 1,372 drugsAshwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...
Read the full Ashwagandha monograph → Herb & supplement monographRhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph →Sources & How We Checked
Adaptive Stress CBD Soft Gels 7.5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 67 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
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