A.C.S. Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking A.C.S. against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
A.C.S. is a dietary supplement by Pure Herbs with 4 active ingredients. Its ingredients are commonly taken for diarrhea, irritable bowel syndrome (ibs) symptoms, digestive upset.Based on those ingredients, 891 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bladderwrack, Kelp, Irish Moss. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against A.C.S. by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with A.C.S. by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of A.C.S. by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
A.C.S. contains four ingredients in a capsule. The product lists a proprietary blend, and then three additional actives: arrowroot, kelp, and bladderwrack (also called sea wrack), plus Irish moss.
Three of these—kelp, bladderwrack, and Irish moss—are sea plants that naturally contain iodine. Arrowroot is a starch.
The capsule itself is made from gelatin.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that A.C.S. works for any condition listed. Arrowroot is rated insufficient evidence for irritable bowel syndrome.
Kelp shows insufficient evidence for prediabetes, weight loss, acid reflux, iodine deficiency, and inflammatory bowel disease. Bladderwrack shows insufficient evidence for aging skin, heart health, constipation, diarrhea, and indigestion.
Irish moss shows insufficient evidence for tiredness, muscle strength, chronic pain, quality of life, and iodine deficiency. In short, the science doesn't support claims for any of these uses yet.
How safe is it?
Well-documented data
Arrowroot is generally well tolerated in food amounts, though medicinal use hasn't been well studied. In one trial, it caused indigestion, constipation, and dark stools in some people.
The three iodine-containing sea plants warrant caution. Bladderwrack has caused goiter and thyroid problems in people who used it, and one case linked it to heart rhythm problems.
Kelp and Irish moss can also affect thyroid function because of their iodine content. For pregnancy, arrowroot is rated possibly safe, but kelp and bladderwrack are rated possibly unsafe because of iodine content and potential heavy metals.
For breastfeeding, kelp and bladderwrack should be avoided because iodine passes into milk and could affect your baby's thyroid. Irish moss is rated likely safe during breastfeeding, though safety data is limited.
Meds to double-check
Moderate interaction found
Check with your pharmacist before starting A.C.S. if you take thyroid hormone (levothyroxine), antithyroid drugs, amiodarone (a heart rhythm medication), or lithium (a mood stabilizer). If you take blood thinners or antiplatelet drugs, mention this product too.
These interactions are Moderate or Minor, but your thyroid and heart function could be affected.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
A.C.S. is best avoided if you take thyroid medication, antithyroid drugs, lithium, amiodarone, or blood thinners—check your exact medications first. If you're pregnant or breastfeeding, talk with your pharmacist or doctor before using it.
The evidence for what this product actually does isn't established yet.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about A.C.S., straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 150 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 13, 2022 |
| DSLD ID | 279881 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for A.C.S. by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 400 mg | -- |
| Arrowroot | 0 NP | -- |
| Kelp | 0 NP | -- |
| Bladderwrack | 0 NP | -- |
| Irish Moss | 0 NP | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As an herbal supplement, take one capsule daily or as directed by your healthcare practitioner.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.
Discontinue use and consult with your doctor if any adverse reactions occur.
Keep out of reach of children
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
A.C.S. by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in A.C.S. by Pure Herbs
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Arrowroot
- › Kelp
- › Bladderwrack
- › Irish Moss
Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
A.C.S. by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
A.C.S. by Pure Herbs contains four ingredients, three of which carry documented interactions with medications.
The most serious concern is with thyroid-related drugs. Bladderwrack and kelp both contain iodine, and bladderwrack in particular has a case on record of triggering overactive thyroid (hyperthyroidism) when combined with lithium—a mood stabilizer.
All three iodine-containing ingredients (kelp, bladderwrack, and Irish moss) can interfere with antithyroid drugs, the thyroid hormone levothyroxine, and amiodarone, a heart rhythm medication. These interactions are rated Moderate because iodine in high doses can cause thyroid problems either way.
Read the full breakdown — every affected drug type, severity by severity
Bladderwrack also has Minor interactions with three types of drugs that your liver processes: CYP2D6 substrates, CYP2C9 substrates, and CYP3A4 substrates. These are mostly theoretical—they haven't been observed in people yet—but they mean the ingredient could theoretically alter how your body handles these medications.
Bladderwrack carries a Minor interaction with blood thinners (anticoagulants) and antiplatelet drugs as well, though evidence for this in humans is weak.
Arrowroot has no known interactions documented in our data. Altogether, these interactions span 892 individual medications.
Before you start A.C.S., use the interaction checker on this page to search your exact medications—especially if you take anything for your thyroid, your heart rhythm, or as a blood thinner.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against A.C.S.?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in A.C.S. interact with 891 drugs. Click any drug to see the details.
3 of the 4 ingredients in A.C.S. interact with drugs. Each result below shows which ingredient is responsible. Bladderwrack Kelp Irish Moss
AmiodaroneCordarone, Pacerone
How Amiodarone interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackCytochrome P450 2c8 (cyp2c8) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Amiodarone interactionIrish MossAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, combining sea moss with amiodarone might cause excessively high iodine levels.
Read the full Irish Moss + Amiodarone interactionKelpAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, combining Ascophyllum nodosum with amiodarone might cause excessively high iodine levels.
Read the full Kelp + Amiodarone interactionCarbimazoleNeo-Mercazole
How Carbimazole interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Read the full Kelp + Carbimazole interactionBladderwrackAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Bladderwrack + Carbimazole interactionIrish MossAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Read the full Irish Moss + Carbimazole interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Conjugated Estrogens interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Conjugated Estrogens interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Conjugated Estrogens interactionDesiccated Thyroid ExtractWesthroid, WP Thyroid
How Desiccated Thyroid Extract interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Desiccated Thyroid Extract interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Desiccated Thyroid Extract interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Desiccated Thyroid Extract interactionDesiccated Thyroid Extract (prescription Drug)Nature-Throid, Thyrar
How Desiccated Thyroid Extract (prescription Drug) interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Desiccated Thyroid Extract (prescription Drug) interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Desiccated Thyroid Extract (prescription Drug) interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Desiccated Thyroid Extract (prescription Drug) interactionDextrothyroxineCholoxin
How Dextrothyroxine interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Dextrothyroxine interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Dextrothyroxine interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Dextrothyroxine interactionHuman Chorionic Gonadotropin (hcg)Pregnyl
How Human Chorionic Gonadotropin (hcg) interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Human Chorionic Gonadotropin (hcg) interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Human Chorionic Gonadotropin (hcg) interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Human Chorionic Gonadotropin (hcg) interactionLevothyroxineEltroxin, Estre, Euthyrox, Levo-T, Levolet, Levothroid +5 more
How Levothyroxine interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Levothyroxine interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Levothyroxine interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Levothyroxine interactionLevothyroxine SodiumErmez, Thyquidity, Tirosint-Sol
How Levothyroxine Sodium interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Levothyroxine Sodium interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Levothyroxine Sodium interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Levothyroxine Sodium interactionLevothyroxine, LiothyronineArmour Thyroid
How Levothyroxine, Liothyronine interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Levothyroxine, Liothyronine interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Levothyroxine, Liothyronine interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Levothyroxine, Liothyronine interactionLiothyronineCytomel
How Liothyronine interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Liothyronine interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Liothyronine interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Liothyronine interactionLiotrixEuthroid 1, Euthroid 1/2, Euthroid 3
How Liotrix interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Liotrix interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Liotrix interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Liotrix interactionLiotrix, T4/t3Euthroid 2
How Liotrix, T4/t3 interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Liotrix, T4/t3 interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Liotrix, T4/t3 interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Liotrix, T4/t3 interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackLithium Moderate
Interaction Summary
Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
Read the full Bladderwrack + Lithium Carbonate (prescription Drug) interactionMenotropinsMenopur, Repronex
How Menotropins interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Menotropins interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Menotropins interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Menotropins interactionMethenamine MandelateMandelamine, Methimazole
How Methenamine Mandelate interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Read the full Kelp + Methenamine Mandelate interactionBladderwrackAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Bladderwrack + Methenamine Mandelate interactionIrish MossAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Read the full Irish Moss + Methenamine Mandelate interactionMethimazoleTapazole
How Methimazole interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Read the full Kelp + Methimazole interactionIrish MossAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Read the full Irish Moss + Methimazole interactionBladderwrackAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Bladderwrack + Methimazole interactionOspemifeneOsphena
How Ospemifene interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Ospemifene interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Ospemifene interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Ospemifene interactionPotassium Iodide (prescription Drug)Thyro-Block
How Potassium Iodide (prescription Drug) interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Read the full Irish Moss + Potassium Iodide (prescription Drug) interactionBladderwrackAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Bladderwrack + Potassium Iodide (prescription Drug) interactionKelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Read the full Kelp + Potassium Iodide (prescription Drug) interactionPropylthiouracil, PtuPropylthiouracil
How Propylthiouracil, Ptu interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Read the full Irish Moss + Propylthiouracil, Ptu interactionBladderwrackAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Bladderwrack + Propylthiouracil, Ptu interactionKelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Read the full Kelp + Propylthiouracil, Ptu interactionTestosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex
How Testosterone Undecanoate interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Testosterone Undecanoate interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Testosterone Undecanoate interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Testosterone Undecanoate interactionThyroglobulinProloid
How Thyroglobulin interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
Irish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Thyroglobulin interactionBladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Thyroglobulin interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Thyroglobulin interactionThyroid HormoneEtwon
How Thyroid Hormone interacts with A.C.S. — through 3 ingredients. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Thyroid Hormone interactionIrish MossThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Read the full Irish Moss + Thyroid Hormone interactionKelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Read the full Kelp + Thyroid Hormone interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abemaciclib interactionAbiraterone
How Abiraterone interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with A.C.S. — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Acalabrutinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in A.C.S. with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bladderwrack
Amiodarone (Cordarone)
Theoretically, combining Fucus vesiculosus with amiodarone might cause excessively high iodine levels.
Fucus vesiculosus contains high concentrations of iodine. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using antithyroid drugs could alter the effects of the antithyroid drugs.
Lithium
Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
There is a case of hyperthyroidism occurring in a patient taking Fucus vesiculosus and lithium. Monitor thyroid hormones closely in patients taking lithium and Fucus vesiculosus concomitantly.
Thyroid Hormone
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using thyroid hormone could alter the effects of thyroid hormone.
Anticoagulant/Antiplatelet Drugs
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro evidence suggests that a constituent of Fucus vesiculosus, known as fucoidan, has anticoagulant effects. However, in clinical research, fucoidan does not seem to have significant anticoagulant activity when taken orally, possibly due to poor absorption.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C8. This interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C9. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, both inhibits and induces CYP2D6. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP3A4. This interaction has not been reported in humans.
Kelp
Amiodarone (Cordarone)
Theoretically, combining Ascophyllum nodosum with amiodarone might cause excessively high iodine levels.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Ascophyllum nodosum while using antithyroid drugs could alter the effects of the antithyroid drugs.
Thyroid Hormone
Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.
Ascophyllum nodosum contains iodine, although the bioavailability of iodine from Ascophyllum nodosum is lower than that of potassium iodide. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Ascophyllum nodosum while using thyroid hormone could alter the effects of thyroid hormone.
Irish Moss
Amiodarone (Cordarone)
Theoretically, combining sea moss with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with sea moss, which contains approximately 4-7 mcg of iodine per gram, might increase the risk of adverse effects from iodine, including altered thyroid function.
Antithyroid Drugs
Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Sea moss contains approximately 4-7 mcg of iodine per gram. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking sea moss could theoretically alter the effects of antithyroid drugs.
Thyroid Hormone
Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Sea moss contains approximately 4-7 mcg of iodine per gram. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking sea moss could theoretically alter the effects of thyroid hormone.
Brand information
Manufacturer and brand details for A.C.S., from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
A.C.S. by Pure Herbs: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind A.C.S.’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Arrowroot
Arrowroot is a starch made from the roots of Maranta arundinacea and is mainly used as a gentle, easy-to-digest thickening agent in food. Some people use it for diarrhea and digestive discom...
Read the full Arrowroot monograph → Herb & supplement monographAscophyllum Nodosum
Interacts with 22 drugsAscophyllum nodosum (often sold as bladderwrack or brown seaweed) is a nutrient-rich algae that people use for weight, blood sugar, and thyroid support, but solid human evidence is limited f...
Read the full Ascophyllum Nodosum monograph → Herb & supplement monographFucus Vesiculosus
Interacts with 891 drugsFucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is little solid human evidence to support mo...
Read the full Fucus Vesiculosus monograph → Herb & supplement monographSea Moss
Interacts with 22 drugsSea moss is a type of red seaweed that is naturally rich in iodine and several minerals, and it is popular as a 'whole-food' supplement. Strong human evidence for most of its health claims i...
Read the full Sea Moss monograph →Sources & How We Checked
A.C.S.'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Arrowroot 2 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24. PubMed
Ascophyllum Nodosum 5 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
- Combet E, Ma ZF, Cousins F, et al. Low-level seaweed supplementation improves iodine status in iodine-insufficient women. Br J Nutr 2014;112:753-61. PubMed
- Simmons-Boyce JL, Purcell SL, Nelson CM, MacKinnon SL. Dietary Ascophyllum nodosum increases urinary excretion of tricarboxylic acid cycle intermediates in male Sprague-dawley rats. J Nutr 2009;139:1487-94. PubMed
- Sorge US, Henriksen M, Bastan A, et al. Short communication: Iodine concentrations in serum, milk, and tears after feeding Ascophyllum nodosum to dairy cows-A pilot study. J Dairy Sci 2016;99:8472-6. PubMed
Fucus Vesiculosus 15 references
- Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine algae (Seaweed) from the St. Lawrence River and likely to be consumed by humans. Environ Res 1999;80:S175-S182. PubMed
- Durig J, Bruhn T, Zurborn KH, et al. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997;85:479-91. PubMed
- Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7.
- Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducing herbal medicines. Arch Intern Med 2005;165:831-4. PubMed
- Okamura K, Inoue K, Omae T. A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol (Copenh) 1978;88:703-12. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
- Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
- Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., I
- Irhimeh, M. R., Fitton, J. H., and Lowenthal, R. M. Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul.Fibrinolysis 2009;20(7):607-610. PubMed
- Arbaizar, B. and Llorca, J. [Fucus vesiculosus induced hyperthyroidism in a patient undergoing concomitant treatment with lithium]. Actas Esp.Psiquiatr. 2011;39(6):401-403.
- Church FC, Meade JB, Treanor RE, and et al. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin. J Biol Chem 2-25-1989;264(6):3618-3623. DOI
- Mathew L, Burney M, Gaikwad A, et al. Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment. Integr Cancer Ther 2017;16(4):572-84.
Sea Moss 3 references
- Darias-Rosales J, Rubio C, Gutiérrez ÁJ, Paz S, Hardisson A. Risk assessment of iodine intake from the consumption of red seaweeds (Palmaria palmata and Chondrus crispus). Environ Sci Pollut Res Int 2020;27(36):45737-45741. PubMed
- U.S. Department of Agriculture (USDA). Agricultural Research Service. FoodData Central. Seaweed, irishmoss, raw. April 2019. Available at: https://fdc.nal.usda.gov/fdc-app.html#/food-details/168456/nutrients. Accessed Aug. 30, 2022.
- Palmieri B, Vadalà M, Laurino C. Clinical effects of overwintered-stressed Chondrus Crispus and non-overwintered-stressed Chondrus crispus dietary supplementations. Asian J Med Sci. 2018; 9(6): 7-13. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC